Publications by authors named "Jihyun Lee"

Hair health critically influences both aesthetic appearance and psychological well-being. Existing treatments often show limited efficacy and may cause side effects. (GP), known for its antioxidant and anti-inflammatory properties, has emerged as a promising botanical agent, although clinical evidence regarding its hair health benefits remains limited.

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Gold standard genomic datasets severely under-represent non-European populations, leading to inequities and a limited understanding of human disease. Therapeutics and outcomes remain hidden because we lack insights that could be gained from analyzing ancestrally diverse genomic data. To address this significant gap, we present PhyloFrame, a machine learning method for equitable genomic precision medicine.

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Article Synopsis
  • Platinum-based chemotherapy combined with immunotherapy shows durable control of advanced urothelial cancer, but its effectiveness varies between cisplatin and carboplatin due to their different impacts on the tumor immune microenvironment.
  • A study analyzing pre-treatment tumor samples from 189 patients revealed that higher lymphoid cell infiltration, especially memory B cells in cisplatin-treated patients, correlated with improved overall survival, a trend not observed in those treated with carboplatin.
  • Gene expression patterns related to B cell memory and associated cytokines were linked to better survival outcomes in multiple cancer patient groups, suggesting memory B cell presence may serve as a promising prognostic biomarker in urothelial cancer treatment.
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Background: Livestock, particularly cattle, are crucial for biotechnology fields, such as genetic breeding, infectious diseases, bioreactors, and specific disease models. However, genetic engineering in cattle has lagged due to long gestation periods, single embryo pregnancies, and high rearing costs. Additionally, the slow validation of germline transmission and the absence of germline-competent embryonic stem cells hinder progress.

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The issue of drug abuse is increasingly becoming a significant concern worldwide. However, the simultaneous detection of a wide spectrum of drug of abuse (DOA), especially in biofluids, is challenging due to their diverse and varied physicochemical properties and matrix effects. Herein, we have developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous detection of 203 DOAs, including amphetamines, opiates, cathinones, phencyclidines, synthetic cannabinoids, cocaine, and metabolites, in 100 μL of urine.

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Almonds contain cyanogenic glycosides (CNGs), prunasin and amygdalin, which generate hydrogen cyanide upon hydrolysis. Different extraction and analytical methods are currently used to measure CNGs or cyanide (CN), necessitating distinct samples and can lead to inconsistent or incomparable results. To address this, we describe a method that uses ultrasonic-assisted sample extraction.

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(Willd.) has been used as food since ancient times, and its roots have been used mainly as a traditional herbal medicine to treat various diseases in East Asia. Puerarin is one of the major active ingredients in the roots of .

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Coffee is an economically important crop and one of the most consumed beverages worldwide. Despite the beneficial potential of microbes in coffee fermentation, studies on their application in dry-processed coffee are lacking. Therefore, we evaluated the microbiological, chemical, and sensory changes in Arabica coffee cherries inoculated with Leuconostoc mesenteroides, Saccharomyces cerevisiae (SC), and Aspergillus oryzae during dry processing.

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: Cellular and humoral immunity are key to the immune response against SARS-CoV-2, but the comparability and correlation across different assays remain underexplored. This study compares three T-cell and three antibody assays in two vaccine groups. : This prospective longitudinal cohort study involved 46 naïve healthcare workers: a total of 11 in the homologous mRNA-1273 group (three doses) and 35 in the heterologous ChAd group (two ChAd doses followed by a BNT booster).

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Background: Although the literature supports a shorter course of 24 h of prophylaxis after head and neck free flap reconstruction, studies supporting this duration do not differentiate between flap types. There is a paucity of evidence on the optimal duration of prophylaxis for osteocutaneous free flaps with hardware, which may have higher rates of post-operative complications compared to other free flaps. This study aimed to examine the effect of different lengths of antibiotic prophylaxis on surgical site infection (SSI) rates after head and neck reconstruction with osteocutaneous free flaps and hardware.

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Background: Mitochondrial function influences Parkinson's disease (PD) through the accumulation of pathogenic alpha-synuclein, oxidative stress, impaired autophagy, and neuroinflammation. The mitochondrial DNA copy number (mtDNA-CN), representing the number of mitochondrial DNA copies within a cell, serves as an easily assessable proxy for mitochondrial function.

Objective: This study aimed to assess the diagnostic and prognostic capabilities of mtDNA-CN in PD.

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Distinguishing between Parkinson's disease (PD) and essential tremor (ET) can be challenging sometimes. Although positron emission tomography can confirm PD diagnosis, its application is limited by high cost and exposure to radioactive isotopes. Patients with PD exhibit loss of the dorsal nigral hyperintensity on brain magnetic resonance imaging (MRI).

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Background: Processed electroencephalogram (EEG) indices are widely used to monitor anesthetic depth. However, their reliability in children under 2 years of age remains questionable. During anesthesia maintenance in this age group, processed EEG indices frequently exhibit unexpectedly elevated values that exceed the intended target range.

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Objectives: Osteoradionecrosis (ORN) following radiation therapy (RT) is a serious complication for patients undergoing head and neck cancer treatment. Recent literature has found an association between ipsilateral external carotid artery (ECA) diameter and the development of ORN. This study evaluates microvascular free-flap arterial anastomosis diameter and the development of ORN.

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This study aimed to evaluate red pepper powder quality by the extent of chilling injury and develop a method for detecting chilling injury-affected pepper powder. Pepper powder produced from chilling injury-affected pepper fruits exhibited increased bitter amino acids, microbial counts, and biogenic amines and decreased sweetness index and organic acid levels. These quality deteriorations indicate the need to detect chilling injury in pepper powders.

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Bunny lines are vertical and diagonal wrinkles attributed to contractions of the nasalis muscle. Common management involves botulinum toxin (BoNT) injections into wrinkles immediately below the nasal bridge. Here, we investigated the anatomical structures underneath bunny lines and their relationships with adjacent muscular structures.

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Background: Breast cancer (BC) survivorship presents significant health disparities, particularly affecting Black women, who experience a 40% higher BC death rate compared to White women. These disparities are exacerbated by comorbidities, which contribute to poorer overall health outcomes. Additionally, Black BC survivors often face psychosocial challenges, including increased stress and lower well-being, which can lead to adverse physical health effects.

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Background: Given the critical role of health professionals in societal health, the development of robust and effective selection methods is of fundamental concern for educational institutions within the field of health sciences education. Conventionally, admission competencies have been determined by institutional authorities. Developing institution-specific competency criteria enables an admission process that is mission- and value-aware, evidence-based, and strategically adaptable.

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This article walks through steps to conduct a meta-analysis of Monte Carlo simulation studies. The selected Monte Carlo simulation studies focused on mixture modeling, which is becoming increasingly popular in the social and behavioral sciences. We provide details for the following steps in a meta-analysis: (a) formulating a research question; (b) identifying the relevant literature; (c) screening of the literature; (d) extracting data; (e) analyzing the data; and (f) interpreting and discussing the findings.

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Article Synopsis
  • BAP1 mutations lead to a loss of function affecting cell cycle and DNA repair, making patients potentially responsive to PARP inhibitors like niraparib.
  • A phase II trial evaluated niraparib in patients with advanced tumors likely to have mBAP1 mutations, focusing on response rates, progression-free survival, and overall survival.
  • Despite not meeting the primary efficacy goal, some clinical benefits were observed in patients with confirmed mBAP1 mutations, suggesting the need for further research.
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Rigidified nucleoside derivatives with (N)-methanocarba replacement of ribose have been repurposed as peripheral subtype-selective 5-HT serotonin receptor antagonists for heart and lung fibrosis and intestinal/vascular conditions. 4'-Cyano derivative (MRS8209; , 4.27 nM) was 47-fold (human binding, but not rat and mouse) and 724-fold (functionally) selective at 5-HTR, compared to antitarget 5-HTR, and predicted to form a stable receptor complex using docking and molecular dynamics.

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Donepezil (DNZ) has been used to treat dementia associated with mild, moderate, or severe Alzheimer's disease (AD). DNZ uptake can alleviate cognitive symptoms in AD patients acetylcholinesterase (AChE) inhibition. However, oral administration of DNZ has limitations, including first-pass metabolism, difficulties with swallowing, and low patient compliance.

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Introduction: In recent years, high-density microelectrode arrays (HD-MEAs) have emerged as a valuable tool in preclinical research for characterizing the electrophysiology of human induced pluripotent stem-cell-derived cardiomyocytes (iPSC-CMs). HD-MEAs enable the capturing of both extracellular and intracellular signals on a large scale, while minimizing potential damage to the cell. However, despite technological advancements of HD-MEAs, there is a lack of effective data-analysis platforms that are capable of processing and analyzing the data, particularly in the context of cardiac arrhythmias and drug testing.

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Article Synopsis
  • ISG15 modification (ISGylation) is important for immune defense against viral infections like SARS-CoV-2 and helps boost innate immunity by modifying signaling proteins.
  • This study examines whether SARS-CoV-2 proteins can be ISGylated, identifying the nucleocapsid (N) protein as a target with crucial modification sites affecting its function.
  • It was found that ISGylation inhibits N protein dimerization and enhances susceptibility to immune responses, while the virus's PLpro protein can remove the ISG15 modification, countering the antiviral effects.
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Purpose: Traditional dissection methods are primarily limited by challenges in identifying minute structures, which can lead to irreversible tissue damage. Anatomical observation of the larynx is particularly challenging in educational and clinical settings owing to its microscopic structures and complex three-dimensional (3D) nature, making it difficult to dissect. Therefore, this study aimed to demonstrate that micro-computed tomography (micro-CT) imaging of the larynx can serve as an effective alternative for educational and clinical purposes, overcoming these limitations.

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Synopsis of recent research by authors named "Jihyun Lee"

  • - Jihyun Lee's recent research focuses on various biomedical applications, including imaging techniques for anatomy, mechanisms of autoimmune responses, and therapeutic interventions for inflammatory diseases, showcasing a comprehensive approach to health and disease management.
  • - Notable findings from Lee's studies include the efficacy of micro-CT imaging for laryngeal structures, the role of complement factor H-related protein 5 in arthritis, and the potential of naringin and cannabidiol as treatments for atopic dermatitis and psoriasis, respectively.
  • - Lee also examines the implications of environmental toxins on aquatic life and the anatomical distribution of nerves in muscle tissues for neuromuscular treatments, indicating a multifaceted exploration of both clinical and ecological health issues.

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