Rewritable Triple-Mode Light-Emitting Display.

Despite great progress in developing mode-selective light emission technologies based on self-emitting materials, few rewritable displays with mode-selective multiple light emissions have been demonstrated. Herein, we present a rewritable triple-mode light-emitting display enabled by stimuli-interactive fluorescence (FL), room-temperature phosphorescence (RTP), and electroluminescence (EL). The display comprises coplanar electrodes separated by a gap, a polymer composite with FL inorganic phosphors (EL/FL layer), and a polymer composite with solvent-responsive RTP additives (RTP layer).

Electrochemiluminescent tactile visual synapse enabling in situ health monitoring.

Tactile visual synapses combine the functionality of tactile artificial synapses with the ability to visualize their activity in real time and provide a direct and intuitive visualization of the activity, offering an efficient route for in situ health monitoring. Herein we present a tactile visual synapse that enables in situ monitoring of finger rehabilitation and electrocardiogram analysis. Repetitive finger flexion and various arrhythmias are monitored and visually guided using the developed tactile visual synapse combined with an electrical and optical output feedback algorithm.

A core-shell fiber moisture-driven electric generator enabled by synergetic complex coacervation and built-in potential.

Moisture-driven electricity generators (MEGs) have been extensively researched; however, high-performance flexible variants have seldom been demonstrated. Here we present a novel complex coacervation with built-in potential strategy for developing a high-performance uniaxial MEG, featuring a core of poly(3,4-ethylenedioxythiophene) (PEDOT) with a built-in charge potential and a gel shell composed of poly(diallyldimethylammonium chloride) (PDDA) and sodium alginate (NaAlg) coacervate. The complex coacervation of two oppositely charged polyelectrolytes produces extra mobile carriers and free volume in the device; meanwhile, the PEDOT core's surface charge significantly accelerates carrier diffusion.

Neuro-Actuating Photonic Skin Enabled by Ion-Gel Transistor with Thermo-Adaptive Block Copolymer.

Despite significant progress in developing artificial synapses to emulate the human nervous system for bio-signal transmission, synapses with thermo-adaptive coloration and soft actuators driven by temperature change have seldom been reported. Herein, a photonic neuro-actuating synaptic skin is presented enabling thermoresponsive synaptic signal transmission, color variation, and actuation. First, a thermoresponsive display synapse is developed based on a 3-terminal ion-gel transistor with a poly (3,4-ethylene dioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) semiconducting channel mixed with 2D titanium carbide (TiCT) MXene and a thermo-adaptive 1D block copolymer (BCP) photonic crystal (PC) gate insulator.

The impact of audiovisual breathing guidance on respiratory-triggered cardiac magnetic resonance cine imaging.

Background: In patients who have difficulty holding their breath, a free breathing (FB) respiratory-triggered (RT) bSSFP cine technique may be used. However, this technique may have inferior image quality and a longer scan time than breath-hold (BH) bSSFP cine acquisitions. This study examined the effect of an audiovisual breathing guidance (BG) system on RT bSSFP cine image quality, scan time, and ventricular measurements.

Rewritable Photoluminescence and Structural Color Display for Dual-Responsive Optical Encryption.

Optical encryption using coloration and photoluminescent (PL) materials can provide highly secure data protection with direct and intuitive identification of encrypted information. Encryption capable of independently controlling wavelength-tunable coloration as well as variable light intensity PL is not adequately demonstrated yet. Herein, a rewritable PL and structural color (SC) display suitable for dual-responsive optical encryption developed with a stimuli-responsive SC of a block copolymer (BCP) photonic crystal (PC) with alternating in-plane lamellae, of which a variety of 3D and 2D perovskite nanocrystals is preferentially self-assembled with characteristic PL, is presented.

Dual-light emitting 3D encryption with printable fluorescent-phosphorescent metal-organic frameworks.

Optical encryption technologies based on room-temperature light-emitting materials are of considerable interest. Herein, we present three-dimensional (3D) printable dual-light-emitting materials for high-performance optical pattern encryption. These are based on fluorescent perovskite nanocrystals (NCs) embedded in metal-organic frameworks (MOFs) designed for phosphorescent host-guest interactions.

Bojungikgi-tang improves skin barrier function and immune response in atopic dermatitis mice fed a low aryl hydrocarbon receptor ligand diet.

Background: The aryl hydrocarbon receptor (AhR) is a transcription factor that plays a crucial role in regulating the immune system and maintaining skin barrier function. AhR signaling is pivotal in the pathogenesis of inflammatory diseases such as atopic dermatitis (AD), and the absence of AhR ligands further contributes to the progression or worsening of AD symptoms.

Methods: AD was induced with 2,4-dinitrochlorobenzene (DNCB), and Bojungikgi-tang (BJIKT) was administered orally daily for 10 weeks.

Sub-30 nm 2D Perovskites Patterns via Block Copolymer Guided Self-Assembly for Color Conversion Optical Polarizer.

Despite the remarkable advances made in the development of 2D perovskites suitable for various high-performance devices, the development of sub-30 nm nanopatterns of 2D perovskites with anisotropic photoelectronic properties remains challenging. Herein, a simple but robust route for fabricating sub-30 nm 1D nanopatterns of 2D perovskites over a large area is presented. This method is based on nanoimprinting a thin precursor film of a 2D perovskite with a topographically pre-patterned hard poly(dimethylsiloxane) mold replicated from a block copolymer nanopattern consisting of guided self-assembled monolayered in-plane cylinders.

Correction: Development and Application of a Metaverse-Based Social Skills Training Program for Children With Autism Spectrum Disorder to Improve Social Interaction: Protocol for a Randomized Controlled Trial.

[This corrects the article DOI: 10.2196/35960.].

Wireless Stand-Alone Trimodal Interactive Display Enabled by Direct Capacitive Coupling.

With recent advances in interactive displays, the development of a stand-alone interactive display with no electrical interconnection is of great interest. Here, a wireless stand-alone interactive display (WiSID), enabled by direct capacitive coupling, consisting of three layers: two in-plane metal electrodes separated by a gap, a composite layer for field-induced electroluminescence (EL) and inverse piezoelectric sound, and a stimuli-responsive layer, from bottom to top, is presented. Alternating current power necessary for field-induced EL and inverse piezoelectric sound is wirelessly transferred from a power unit, with two in-plane electrodes remotely separated from the WiSID.

Development and Application of a Metaverse-Based Social Skills Training Program for Children With Autism Spectrum Disorder to Improve Social Interaction: Protocol for a Randomized Controlled Trial.

Background: Autism spectrum disorder (ASD) is characterized by abnormalities in social communication and limited and repetitive behavioral patterns. Children with ASD who lack social communication skills will eventually not interact with others and will lack peer relationships when compared to ordinary people. Thus, it is necessary to develop a program to improve social communication abilities using digital technology in people with ASD.

Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling.

Adult human cardiomyocytes have an extremely limited proliferative capacity, which poses a great barrier to regenerative medicine and research. Human embryonic stem cells (hESCs) have been proposed as an alternative source to generate large numbers of clinical grade cardiomyocytes (CMs) that can have potential therapeutic applications to treat cardiac diseases. Previous studies have shown that bioactive lipids are involved in diverse cellular responses including cardiogenesis.

Accelerated free-breathing 3D whole-heart magnetic resonance angiography with a radial phyllotaxis trajectory, compressed sensing, and curvelet transform.

Purpose: To develop and validate an accelerated free-breathing 3D whole-heart magnetic resonance angiography (MRA) technique using a radial k-space trajectory with compressed sensing and curvelet transform.

Method: A 3D radial phyllotaxis trajectory was implemented to traverse the centerline of k-space immediately before the segmented whole-heart MRA data acquisition at each cardiac cycle. The k-space centerlines were used to correct the respiratory-induced heart motion in the acquired MRA data.

Polymer-Laminated TiCT MXene Electrodes for Transparent and Flexible Field-Driven Electronics.

MXenes (TiCT) are two-dimensional transition-metal carbides and carbonitrides with high conductivity and optical transparency. However, transparent MXene electrodes with high environmental stability suitable for various flexible organic electronic devices have rarely been demonstrated. By laminating a thin polymer film onto a solution-processed MXene layer to protect the MXene film from harsh environmental conditions, we present transparent and flexible MXene electronic devices.

Genotoxicity of Asiasari Radix et Rhizoma (Aristolochiaceae) ethanolic extract in vitro and in vivo.

Ethnopharmacological Relevance: Traditional herbal medicines have diverse efficacy and are increasingly used worldwide. However, some of these herbal medicines have toxicities or side effects, but the scientific understanding of traditional herbal medicine toxicity has not yet been established. Asiasari Radix et Rhizoma (ARE) is known as a herbal medicine used to relieve pain, and recent studies have shown that ARE has anticancer and antimelanogenesis efficacy.

Age and Gender Effects on Genotoxicity in Diesel Exhaust Particles Exposed C57BL/6 Mice.

There is growing evidence that the accumulation of DNA damage induced by fine particulate matter (PM) exposure is an underlying mechanism of pulmonary disease onset and progression. However, there is a lack of experimental evidence on whether common factors (age, gender) affect PM induced genomic damage. Here, we assessed the DNA damage potency of PM using conventional genotoxicity testing in old male and female mice aged 8 and 40 weeks.

Machine learning phenotyping of scarred myocardium from cine in hypertrophic cardiomyopathy.

Aims: Cardiovascular magnetic resonance (CMR) with late-gadolinium enhancement (LGE) is increasingly being used in hypertrophic cardiomyopathy (HCM) for diagnosis, risk stratification, and monitoring. However, recent data demonstrating brain gadolinium deposits have raised safety concerns. We developed and validated a machine-learning (ML) method that incorporates features extracted from cine to identify HCM patients without fibrosis in whom gadolinium can be avoided.

Sensitivity of Myocardial Radiomic Features to Imaging Parameters in Cardiac MR Imaging.

Background: Cardiac magnetic resonance (MR) images are often collected with different imaging parameters, which may impact the calculated values of myocardial radiomic features.

Purpose: To investigate the sensitivity of myocardial radiomic features to changes in imaging parameters in cardiac MR images.

Study Type: Prospective.

Discordance in Scar Detection Between Electroanatomical Mapping and Cardiac MRI in an Infarct Swine Model.

Objectives: This study sought to investigate the sensitivity of electroanatomical mapping (EAM) to detect scar as identified by late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR).

Background: Previous studies have shown correlation between low voltage electrogram amplitude and myocardial scar. However, voltage amplitude is influenced by the distance between the scar and the mapping surface and its extent.

Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy.

Background In patients with nonischemic cardiomyopathy, nonischemic fibrosis detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance is related to adverse cardiovascular outcomes. However, its relationship with left ventricular (LV) mechanical deformation parameters remains unclear. We sought to investigate the association between LV mechanics and the presence, location, and extent of fibrosis in patients with nonischemic cardiomyopathy.

Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target.

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the conversion of oncogenic prostaglandin E to non-tumerigenic 15-keto prostaglandin E. In the present study, we found that curcumin, a yellow coloring agent present in the rhizome of Curcuma longa Linn (Zingiberaceae), induced expression of 15-PGDH at the both transcriptional and translational levels in normal rat gastric mucosal cells. By using deletion constructs of 15-PGDH promoter, we were able to demonstrate that activator protein-1 (AP-1) is the principal transcription factor responsible for regulating curcumin-induced 15-PGDH expression.

Reproducibility of Segmentation-based Myocardial Radiomic Features with Cardiac MRI.

Purpose: To investigate reproducibility of myocardial radiomic features with cardiac MRI.

Materials And Methods: Test-retest studies were performed with a 3-T MRI system using commonly used cardiac MRI sequences of cine balanced steady-state free precession (cine bSSFP), T1-weighted and T2-weighted imaging, and quantitative T1 and T2 mapping in phantom experiments and 10 healthy participants (mean ± standard deviation age, 29 years ± 13). In addition, this study assessed repeatability in 51 patients (56 years ± 14) who underwent imaging twice during the same session.