Palladium Nanoparticle-Decorated Porous Carbon Nanoflakes as High-Activity Catalyst for Electrooxidation of Alcohol.

A facile technique for the preparation of a multicomponent electrocatalyst that shows promising activity for the electrooxidation of alcohol has been demonstrated. The synthesis involves the preparation of hyper-crosslinked polydichloroxylene solid nanoflakes that are hybridized with PdCl₂. The hybrid is reduced in an aqueous NaBH₄ solution to fabricate Pd nanoparticle-decorated hyper-crosslinked polydichloroxylene.

A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson's disease, in healthy volunteers.

Background: KM-819 is a novel FAS-associated factor 1 (FAF1) inhibitor, and a neuroprotective agent, under clinical development for the treatment of Parkinson's disease as a disease-modifying drug.

Methods: This first-in-human, single and multiple ascending dose study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 in healthy volunteers. Additionally, the effect of age on safety and pharmacokinetics were assessed.