Publications by authors named "Jihuan Wang"
Ubiquitination plays a pivotal regulatory role in tumor progression. Among the components of the ubiquitin-proteasome system (UPS), ubiquitin-protein ligase E3 has emerged as a key molecule. Nevertheless, the biological functions of E3 ubiquitin ligases and their potential mechanisms orchestrating glycolysis in gastric cancer (GC) remain to be elucidated.
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- This study investigates the role of telomere maintenance in gastric cancer (GC) and aims to identify molecular subtypes based on telomere-related genes.
- Researchers found three distinct telomere maintenance-associated clusters (TMCs) that show differences in clinical features and the tumor microenvironment.
- They also discovered five key genes, including TUBB6, which is linked to cancer cell growth and movement, providing potential new biomarkers for GC treatment.
Background: Liver metastasis (LM) is one of the most common distant metastases of gastric cancer (GC). However, the mechanisms underlying the LM of GC (GC-LM) remain poorly understood. This study aimed to identify the tumour-secreted protein associated with GC-LM and to investigate the mechanisms by which this secreted protein remodels the liver microenvironment to promote GC-LM.
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- Distal clavicle fractures often occur alongside shoulder injuries and were evaluated in a study focusing on a new fixation method using a miniature locking plate and single button reconstruction for the coracoclavicular ligaments in seven patients.
- The study followed these patients for 12 months, all classified with type IIb fractures, and reported successful outcomes with complete radiographic union and no complications like nonunion or osteolysis.
- At the 1-year mark, patients showed strong functional recovery, indicated by high mean scores on various assessments related to shoulder performance and disability, suggesting the technique is effective for stability in these injuries.