Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking.

Alzheimer's disease is a progressive neurodegenerative disorder with limited treatment options. Lingonberry ( L.) has demonstrated neuroprotective and anti-inflammatory properties, yet the underlying mechanisms remain unclear.

Molecular phylogenetic analyses reveal multiple long-distance dispersal events and extensive cryptic speciation in (Orchidaceae), an isolated basal Epidendroid genus.

Introduction: The terrestrial orchid genus is diagnosed by its hysteranthous pattern of emergence but is nested among leafless myco-heterotrophic lineages in the lower Epidendroideae. Comprising ca. 80 species distributed across Africa, Asia and Oceania, the genus remains poorly known and plagued by vague and overlapping species circumscriptions, especially within each of a series of taxonomically intractable species complexes.

Defect-Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re-polarization, and Ca Channel Activation for Therapy of MRSA-Infected Wounds and Osteomyelitis.

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure of antibiotics in resistant infections leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with deep penetration. Currently, PZDT demands further investigation for improved treatment outcomes and the corresponding therapeutic mechanisms.

Verapamil inhibits ferroptosis in septic acute lung injury by blocking L-type calcium channels.

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), result from pulmonary edema and alveolar-capillary barrier disruption due to inflammation, often triggered by conditions like sepsis. Sepsis-induced ALI (SALI) involves extensive damage to vascular endothelium and alveolar epithelium, leading to respiratory failure. Our study explores ferroptosis, an iron-dependent cell death pathway, and calcium dysregulation in SALI.

Emotional Labor of Caregivers of Elderly Patients with Dementia and Disabilities in a Psychiatric Hospital in China.

BACKGROUND Studies on the emotional labor of caregivers of elderly people with dementia and disabilities are rare. This study aimed to investigate the emotional labor of caregivers of elderly patients with dementia and disabilities in a psychiatric hospital in China and to propose measures to improve emotional labor of the caregivers. MATERIAL AND METHODS Convenience sampling was used in this study.

A telomere-to-telomere gap-free reference genome of provides insights into the molecular mechanism underlying petal shape changes.

, an arbor tree of the Oleaceae family, is an ecologically and economically valuable ornamental plant for its remarkable adaptability in landscaping. During breeding, we observed diverse floral shapes; however, no available genome for has hindered the widespread identification of genes related to flower morphology. Thus, a telomere-to-telomere (T2T) gap-free genome was generated.

Revealing the promoting effect of heterojunction on NiS/MoO in urea oxidation assisted water electrolysis.

Investigating efficient non-precious metal-based catalysts for water electrolysis to produce hydrogen is a significant and urgent need in the field of clean energy technologies. Moreover, utilizing transition metal dichalcogenides (TMDs) to replace the oxygen evolution reaction (OER) with the urea oxidation reaction (UOR), coupled with the hydrogen evolution reaction (HER), is an effective energy-saving hydrogen production method. A heterostructure NiS/MoO catalyst was prepared by a simple method, which exhibits excellent activity for UOR, requiring only 1.

Heat resistance differences are common between both vegetative cells and spores of type F isolates carrying a chromosomal vs plasmid-borne enterotoxin gene.

type F isolates utilize enterotoxin (CPE) to cause food poisoning (FP) and nonfoodborne gastrointestinal diseases. The enterotoxin gene () can be located on either the chromosome or plasmids, but most FP isolates carry a chromosomal (c) gene. Our 2000 article in (66:3234-3240, 2000, https://doi.

Mycobacterium tuberculosis protein Rv2652c enhances intracellular survival by inhibiting host immune responses.

Backgrounds: Mycobacterium tuberculosis (Mtb), the pathogen responsible for tuberculosis, secretes a multitude of proteins that modulate the host's immune response to ensure its own persistence. The region of difference (RD) genes encoding proteins play key roles in TB immunity and pathogenesis. Nevertheless, the roles of the majority of RD-encoded proteins remain to be elucidated.

Plastome Evolution, Phylogenomics, and DNA Barcoding Investigation of (Aeridinae, Orchidaceae), with a Focus on the Systematic Position of .

is an orchid genus containing about 70 species in tropical and subtropical Asia with high morphological diversity. The phylogenetic relationships among this genus have not been fully resolved, and the plastome evolution has not been investigated either. In this study, five plastomes of were newly reported, and sixteen plastomes of were used to conduct comparative and phylogenetic analyses.

Recovering high-quality glass fibers from end-of-life wind turbine blades through swelling-assisted low-temperature pyrolysis.

The recycling of end-of-life wind turbine blades has become a global environmental challenge driven by the rapid growth of wind power. Pyrolysis is a promising method for recovering glass fibers from these discarded blades, but traditional pyrolysis is often operated at high temperatures, which degrades the mechanical properties of recovered fibers. To address this issue, a swelling-assisted pyrolysis method was proposed to recover high-quality glass fibers from end-of-life wind turbine blades at low temperatures.

Revealing the Synergistic Effect of Cation and Anion Vacancies on Enhanced Fenton-Like Reaction: The Electron Density Modulation of O 2p-Co 3d Bands.

Defect engineering is considered as a flexible and effective mean to improve the performance of Fenton-like reactions. Herein, a simple method is employed to synthesize CoO catalysts with Co-O vacancy pairs (V) for peroxymonosulfate (PMS) activation. Multi-scaled characterization, experimental, and simulation results jointly revealed that the cation vacancies-V contributed to enhanced conductivity and anion vacancies-V provided a new active center for the O generation.

Complete telomere-to-telomere assemblies of two sorghum genomes to guide biological discovery.

The assembly of two sorghum T2T genomes corrected the assembly errors in the current reference, uncovered centromere variation, boosted functional genomics research, and accelerated sorghum improvement.

The biology and pathogenicity of type F: a common human enteropathogen with a new(ish) name.

SUMMARYIn the 2018-revised typing classification system, isolates carrying the enterotoxin () and alpha toxin genes but no other typing toxin genes are now designated as type F. Type F isolates cause food poisoning and nonfoodborne human gastrointestinal (GI) diseases, which most commonly involve type F isolates carrying, respectivefooly, a chromosomal or plasmid-borne gene. Compared to spores of other isolates, spores of type F chromosomal isolates often exhibit greater resistance to food environment stresses, likely facilitating their survival in improperly prepared or stored foods.

Multimodal fall detection for solitary individuals based on audio-video decision fusion processing.

Falls often pose significant safety risks to solitary individuals, especially the elderly. Implementing a fast and efficient fall detection system is an effective strategy to address this hidden danger. We propose a multimodal method based on audio and video.

Formation and prediction of heterocyclic amines and N-nitrosamines in smoked sausages using back propagation artificial neural network.

Background: Heterocyclic amines (HAs) and N-nitrosamines (NAs) are formed easily during the thermal processing of food, and epidemiological studies have demonstrated that consuming HAs and NAs increases the risk of cancer. However, there are few studies on the application of back propagation artificial neural network (BP-ANN) models to simultaneously predict the content of HAs and NAs in sausages. This study aimed to investigate the effects of cooking time and temperature, smoking time and temperature, and fat-to-lean ratio on the formation of HAs and NAs in smoked sausages, and to predict their total content based on the BP-ANN model.

Prognostic value of serum phosphate levels in sepsis: a systematic review and meta-analysis.

Background: There remain controversies over the conclusion of different serum phosphate levels as prognostic predictors of sepsis patients. As such, this study investigated the association between different serum phosphate and the prognosis of sepsis.

Methods: Data from PubMed, Embase, Cochrane Library, and Web of Science were systematically retrieved from the inception of databases to June 1, 2023 and independently screened and extracted by two authors.

Efficient and safe use of a slow-release Mn material for three sequential crops of rice in Cd-contaminated paddy soils.

Traditional passivators reduce the effectiveness of Cd by ion exchange, chemisorption, and complexation in soil. However, traditional passivators have defects such as easy aging and poor durability, which not only reduce the treatment efficiency but also increase the risk of primary soil environmental pollution. For this reason, considering that Mn and Cd have physiological antagonism in rice, sepiolite-supported manganese ferrite (SMF) was prepared in this study to improve passivation persistence.