New Therapeutic Method for Alleviating Damage of Acute Kidney Injury Through Gene Promoter I-Motif.

Acute kidney injury (AKI) is a global public health problem with its pathogenesis not fully understood. Excessive apoptosis of renal tubular epithelial cells is an important feature of AKI patients, and therefore an anti-apoptotic approach could be used in the treatment for AKI. Up-regulation of B-cell lymphoma-2 () gene and protein has been found to be correlated with anti-apoptosis of cells.