Microbial inactivation of pressure spray combined with high-voltage electrospray and its application in honey raspberry juice.

Pressure spray combined with high-voltage electrospray (PS-ES) has garnered considerable interest as a novel, non-thermal approach for microbial inactivation and preservation of liquid food. This study compared PS-ES with heat treatment (HT) to understand its inactivation mechanism against E. coli and S.

Protective effect of essential oil and its main component thymol on learning and memory impairment in aging mice.

The aging process of human beings is accompanied by the decline of learning and memory ability and progressive decline of brain function, which induces Alzheimer's Disease (AD) in serious cases and seriously affects the quality of patient's life. In recent years, more and more studies have found that natural plant antioxidants can help to improve the learning and memory impairment, reduce oxidative stress injury and aging lesions in tissues. This study aimed to investigate the effect of essential oil and its main component thymol on learning and memory impairment in D-galactose-induced aging mice and its molecular mechanism.

The improvement of essential oil on learning and memory impairment of d-galactose-induced mice through Nrf2/NF-κB pathway.

Essential oil of (EOC) is a essential substance extracted from with the excellent anti-oxidant effect. However, it is still unclear whether EOC can improve learning and memory impairment and its mechanism. The purpose of this study was to investigate the effect of EOC on learning and memory impairment induced by D-galactose (D-gal) in mice and reveal its mechanism.

A Conductive Bamboo Fabric with Controllable Resistance for Tailoring Wearable Sensors.

Force-sensitive textile sensors are becoming a research hotspot as a part of wearable devices. The core research topic is the method to obtain the sensing property, which decides the sensitivity and service performance of the sensors. Here, we introduce a new sensing mechanism based on a statistical change of contact resistance that exhibits an exponential decay upon strain or pressure, where a novel conductive bamboo fabric is prepared and the dependence of electric conductivity on the fabric structure is discovered.

SIPA1 boosts migration and proliferation, and blocks apoptosis of glioma by activating the phosphorylation of the FAK signaling pathway.

Background: We aimed to analyze the regulatory effects of SIPA1 (signal-induced proliferation-associated protein 1) on glioma progression and the dominant signaling pathway.

Methods: Differential level of SIPA1 in glioma and normal tissues and cells was determined. Migratory, proliferative, apoptotic and cell cycle progression changes in A172 cells with overexpression or knockdown of SIPA1 were examined.

Clinical and Imaging Study of Repetitive Transcranial Magnetic Stimulation in the Treatment of Morphine Dependence Through mGluR5/TDP43/NR2B Pathway.

Morphine is tolerable after long-term use. After long-term use, it will have a great impact on the human body, and the treatment effect is not good. In recent years, the continuous development of repetitive transcranial magnetic stimulation (rTMS) treatment technology has made a treatment.

Hawthorn pectin: Extraction, function and utilization.

Pectin has been widely used as emulsifiers, gelling agents, glazing agents, stabilizers, and thickeners in food products. Hawthorn pectin has a higher viscosity than other foods-derived pectin such as lemon and apple pectin. It is also reported as a multifunctional fruit substance, which reduces the risk of hyperlipidemia and dyslipidemia.

Long-term effect of bilateral anterior elevation of occlusion on the temporomandibular joints.

Objective: Incisors tubed prosthesis with bilateral anterior elevation (BAE) relation had been reported to stimulate the proliferative response in the mandibular condylar cartilage of mice, thus the prosthetic occlusion elevation had been proposed to treat cartilage degeneration. Currently, we aimed to detect the long-term effect of BAE on temporomandibular joints (TMJs).

Materials And Methods: Twelve 6-week-old female mice were assigned to age-matched control and BAE groups (n = 6).

Effectiveness and safety of repetitive transcranial magnetic stimulation for the treatment of morphine dependence: A retrospective study.

Morphine dependence (MD) is a very common complication because of the chronic morphine consumption. Studies suggest that repetitive transcranial magnetic stimulation (rTMS) can be used for the treatment of MD. However, there is still lacking evidence to support rTMS for MD.

Strain-Induced Form Transition and Crystallization Behavior of the Transparent Polyamide.

A transparent polyamide, poly(4,4'-aminocyclohexyl methylene dodecanedicarboxylamide) (PAPACM12), was studied and characterized by in situ wide-angle X-ray diffraction (WAXD) to establish the relationship between its crystallization behavior, crystalline form transition under external fields, and macroscopic properties. During the heating process, cold crystallization occurred and increased, and there was no form transition below the melting point. During the isothermal process, PAPACM12 exhibited the same crystalline structure as that during the heating process.

Effects of ethyl acetate extract from Coreopsis tinctoria on learning and memory impairment in d-galactose-induced aging mice and the underlying molecular mechanism.

The aim of this study was to investigate the effects of ethyl acetate extract from Coreopsis tinctoria (EACC) on learning and memory impairment in d-galactose-induced aging mice and the underlying molecular mechanism. The composition of EACC was analyzed by UPLC-MS, and the targets and pathways of EACC to improve learning and memory impairment were predicted and analyzed by the network pharmacology method. A mouse aging model was established by subcutaneous injection of d-galactose in mice, and EACC and piracetam were given to the model mice by gavage to observe their behavioral changes and changes in their SOD and GSH-Px activities in MDA contents in their peripheral blood serum and in the contents of Glu and GABA in their brain tissues.

Enterovirus 71 induces autophagy in mice via mTOR inhibition and ERK pathway activation.

Aims: Enterovirus 71 (EV71) is one of the main viruses that cause hand-foot-mouth disease; however, its pathogenic mechanism remains unclear. This study characterized the relationship between EV71 infection and autophagy in vivo and explored the molecular mechanism underlying EV71-induced autophagy.

Materials And Methods: A mouse model of EV71 infection was prepared by intraperitoneally injecting one-day-old BALB/c suckling mice with 30 μL/g of EV71 virus stock solution for 3 days.

Highly Efficient Photochromic Tungsten Oxide@PNIPAM Composite Spheres with a Fast Response.

Coloration efficiency and a fast response are important in developing materials for optical switching. A novel, highly efficient photochromic tungsten oxide@poly(-isopropylacrylamide) (PNIPAM) hybrid sphere is reported, whose colors can be rapidly converted between yellow and blue under different lights. The color change can be seen clearly even if the tungsten oxide content in the hybrid sphere is very low, exhibiting outstanding coloration efficiency of tungsten oxide.

Effects of wogonoside on the inflammatory response and oxidative stress in mice with nonalcoholic fatty liver disease.

Context: Wogonoside has many pharmacological activities, but whether it has a protective effect against non-alcoholic fatty liver disease (NAFLD) has not been reported.

Objective: This study investigates the protective effect of wogonoside against NAFLD in mice and its potential mechanism.

Materials And Methods: C57BL/6 mice were randomly divided into control group, NAFLD group and low-, medium- and high-dose wogonoside groups (5, 10 and 20 mg/kg, respectively) (= 12).

Biomechanically reduced expression of Derlin-3 is linked to the apoptosis of chondrocytes in the mandibular condylar cartilage via the endoplasmic reticulum stress pathway.

Objective: The present purpose was to investigate the involvement of Derlin-3 in the endoplasmic reticulum stress pathway-mediated apoptosis of chondrocytes in biomechanically stimulated mandibular condylar cartilage.

Design: First, fluid flow shear stress (FFSS) was applied to ATDC5 cells with or without overexpression of Derlin-3 by lentiviral transduction or silencing of Derlin-3 by siRNA transfection. Apoptosis was evaluated by TUNEL assay.

Antibacterial properties and biocompatibility in vivo and vitro of composite coating of pure magnesium ultrasonic micro-arc oxidation phytic acid copper loaded.

Bone infection and implant secondary removal remains a clinical challenge. We used ultrasonic micro-arc oxidation (UMAO) and conversion of phytic acid copper plating to prepare a pure magnesium polyhydric biofilm; we evaluated the surface microstructures, phase, element composition, and wettability of the film in vitro. The antibacterial activity of films with different Cu contents was confirmed by coating method, imaging examination, and microbiological cultures in vitro.

Hydrothermal Growth and Electrochemical Performance of Carbon-Coated Porous SnO₂ Nanospheres.

The porous SnO2 nanospheres were fabricated by hydrothermal method and then the carbon layer was coated as a buffer cushion through a facile hydrothermal process in aqueous D-glucose followed by a subsequent calcination at 500 °C in a nitrogen (N2) atmosphere. The materials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), thermogravimetric analysis and Raman spectra. Based on the experimental results, the thickness of carbon layer could be well-controlled by hydrothermal time and D-glucose concentration.

Construction and application of a new cell electrochemical detecting system based on the hyposmotic principle.

A new cell electrochemical detecting system has been constructed based on the hyposmotic principle, in which the electrochemical signals have been strengthened by about 109.75% for the signal at about +0.70 V and 532.

Electrochemical estrogen screen method based on the electrochemical behavior of MCF-7 cells.

It was an urgent task to develop quick, cheap and accurate estrogen screen method for evaluating the estrogen effect of the booming chemicals. In this study, the voltammetric behavior between the estrogen-free and normal fragmented MCF-7 cell suspensions were compared, and the electrochemical signal (about 0.68V attributed by xanthine and guanine) of the estrogen-free fragmented MCF-7 cell suspension was obviously lower than that of the normal one.

Bi-compartmental responsive polymer particles.

A novel type of bi-compartmental copolymer particle was synthesized in one-pot by controlling the phase separation during the polymerization process. The resulting particles have two distinct compartments, one consisting of mainly poly(acrylic acid) (PAA) and the other of poly(N,N'-isopropylacrylamide) (PNIPAM). The particles exhibit changeable shapes and properties, such as swelling in solvents and deposition on surfaces, and can be used to control emulsification as a function of pH.

Influence of calcium hydroxide-loaded microcapsules on osteoprotegerin and receptor activator of nuclear factor kappa B ligand activity.

Introduction: Calcium hydroxide (Ca[OH]2) microcapsules were synthesized to allow controlled release of Ca(OH)2. The aim of this study was to evaluate the influence of Ca(OH)2 microcapsules on osteoprotegerin (OPG) activity, receptor activator of nuclear factor kappa B ligand (RANKL) activity, and the OPG/RANKL ratio compared with pure Ca(OH)2 powder and Vitapex (Neo Dental Chemical Products Co Ltd, Tokyo, Japan).

Methods: One formula of Ca(OH)2 microcapsules was evaluated, and pure Ca(OH)2 powder was used as a control.

In situ electrochemical assessment of cytotoxicity of chlorophenols in MCF-7 and HeLa cells.

An in situ electrochemical method was used to assess the cytotoxicity of chlorophenols using human breast cancer (MCF-7) and cervical carcinoma (HeLa) cells as models. On treatment with different chlorophenols, the electrochemical responses of the selected cells, resulting from the oxidation of guanine and xanthine in the cytoplasm, indicated the cell viability. In addition, the in situ in vitro electrochemical method was further compared with the traditional MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays.

Two-signal electrochemical method for evaluation suppression and proliferation of MCF-7 cells based on intracellular purine.

Two electrochemical signals ascribed to xanthine/guanine and hypanthine/adenine in MCF-7 cells were detected at 0.726 and 1.053 V, respectively.