Antigenotoxic and Antimutagenic Activities of Probiotic Lactobacillus rhamnosus Vc against N-Methyl-N'-Nitro-N-Nitrosoguanidine.

The present study provides experimental evidence of in vivo reduction of genotoxic and mutagenic activities of potent carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by the strain Lactobacillus rhamnosus Vc. In vitro studies revealed that coincubation of MNNG with viable cells of L. rhamnosus Vc resulted in the detoxification of the parent compound accompanied with reduction in genotoxicity (69%) and mutagenicity (61%) as evaluated by SOS-Chromotest and Ames test, respectively.

Movement and bioaccumulation of chromium in an artificial freshwater ecosystem.

In the present study, a small fresh water aquatic ecosystem was created into a small test tank to evaluate the movement and bioaccumulation of Cr (VI) through water, sediment, a macrophyte Hydrilla, small fish guppy, and few key organs of magur, Clarias batrachus. The Cr (VI) intoxication was imposed of as a single dose of 30 mg/l concentration for a wide range of exposure durations like 1, 7, 14 and 21 days. After 1 day of exposure the total Cr (VI) load was very high in the water and sediment samples (5.