Publications by authors named "Jigisha Srivastav"
Article Synopsis
- Familial Mediterranean fever (FMF) is a genetic disorder marked by recurrent fever, rashes, and inflammation in multiple body tissues.
- FMF can show nonspecific symptoms, which makes it difficult to differentiate from other conditions, including metastatic Crohn's disease (MCD).
- The text discusses a patient whose FMF diagnosis was delayed due to symptoms that closely resembled those of MCD.
Recently, we observed that the TGF-β pathway is altered in 39% of HCCs. The alterations are correlated with a raised HMGA2 level. Therefore, we compared genetic alterations of HMGA2 and 43 TGF-β pathway core genes in HCC patients from TCGA database.
View Article and Find Full Text PDFBackground & Aims: We studied interactions among proteins of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family, which interact with microbes, and transforming growth factor beta (TGFB) signaling pathway, which is often altered in colorectal cancer cells. We investigated mechanisms by which CEACAM proteins inhibit TGFB signaling and alter the intestinal microbiome to promote colorectal carcinogenesis.
Methods: We collected data on DNA sequences, messenger RNA expression levels, and patient survival times from 456 colorectal adenocarcinoma cases, and a separate set of 594 samples of colorectal adenocarcinomas, in The Cancer Genome Atlas.
Article Synopsis
- Overdiagnosis and overtreatment of prostate cancer (CaP) in the U.S. is largely due to reliance on PSA screening, prompting the search for better diagnostic biomarkers.
- Researchers investigated the presence of autoantibodies (AAbs) against the ERG oncoprotein in CaP patients and found significantly higher levels in their blood compared to healthy individuals.
- The study suggests that a panel of AAbs including anti-ERG, AMACR, and HERV-K Gag could effectively differentiate CaP patients from healthy controls, indicating their potential as useful biomarkers for diagnosis and prognosis.