Blocking METTL3-mediated lncRNA FENDRR silence reverses cisplatin resistance of lung adenocarcinoma through activating TFRC-mediated ferroptosis pathway.

Targeting ferroptosis pathway becomes a new solution for cisplatin (DDP) resistance in lung adenocarcinoma (LUAD), and further research is required to explore the molecular mechanisms underlying ferroptosis and DDP resistance, providing biotargets for LUAD treatment. In this study, DDP-sensitive A549 cells and DDP-resistant A549/DDP cells were treated with DDP, DDP sensitivity was detected through using CCK-8 method and colony formation assay, ferroptosis-related markers were determined through commercial kits, and the molecular regulatory mechanism was analyzed through methylated RNA immunoprecipitation, RNA pull-down, dual luciferase assay, quantitative real-time polymerase chain reaction and western blotting assay. Results showed that compared to A549 cells, FENDRR was downregulated in A549/DDP cells, and FENDRR increased iron content, labile iron pool, lipid peroxidation, LDH release and ROS levels, accelerating ferroptosis to promote DDP sensitivity.

Learnable sparse dictionary compressed sensing for channeled spectropolarimeter.

Channeled spectropolarimetry enables real-time measurement of the polarimetric spectral information of the target. A crucial aspect of this technology is the accurate reconstruction of Stokes parameters spectra from the modulated spectra obtained through snapshot measurements. In this paper, a learnable sparse dictionary compressed sensing method is proposed for channeled spectropolarimeter (CSP) spectral reconstruction.

Broadband light absorption by a hemispherical concentric nanoshell array.

Achieving highly efficient broadband absorption is an important research area in nanophotonics. In this paper, a novel method is proposed to design broadband near-perfect absorbers, consisting of a four-layer hemispherical concentric nanoshell array. The proposed nanostructure supports absorptivity exceeding 95% in the entire visible region, and the absorption bandwidth is determined by the interaction or 'hybridization' of the plasmons of the inner and outer metal-based nanoshells.

Physics-guided neural network for channeled spectropolarimeter spectral reconstruction.

A reconstruction method incorporates the complete physical model into a traditional deep neural network (DNN) is proposed for channeled spectropolarimeter (CSP). Unlike traditional DNN-based methods that need to employ training datasets, the method starts from randomly initialized parameters which are constrained by the CSP physical model. It iterates through the gradient descent algorithm to obtain the estimation of the DNN parameters and then to obtain the mapping relationship.

Strong coupling of multiple optical interface modes with ultra-narrow linewidth in one-dimensional topological photonic heterostructures.

Coherent coupling of optical modes with a high Q-factor underpins realization of efficient light-matter interaction with multi-channels in resonant nanostructures. Here we theoretically studied the strong longitudinal coupling of three topological photonic states (TPSs) in a one-dimensional topological photonic crystal heterostructure embedded with a graphene monolayer in the visible frequencies. It is found that the three TPSs can strongly interplay with one another in the longitudinal direction, enabling a large Rabi splitting (∼ 48 meV) in spectral response.

Polarization-selective narrow band dual-toroidal-dipole resonances in a symmetry-broken dielectric tetramer metamaterial.

Here we propose a metasurface consisting of symmetry-broken dielectric tetramer arrays, which can generate polarization-selective dual-band toroidal dipole resonances (TDR) with ultra-narrow linewidth in the near-infrared region. We found, by breaking the C symmetry of the tetramer arrays, two narrow-band TDRs can be created with the linewidth reaching ∼ 1.5 nm.

Ultra-narrow-band circular dichroism by surface lattice resonances in an asymmetric dimer-on-mirror metasurface.

Narrow-linewidth circular dichroism (CD) spectroscopy is a promising candidate to push the limits of molecular handedness detection toward a monolayer or even to a single molecule level. Here, we designed a hybrid metasurface consisting of a periodic array of symmetry-breaking dielectric dimers on a gold substrate, which can generate strong CD of 0.44 with an extremely-narrow linewidth of 0.

Recent Progress on Optical Micro/Nanomanipulations: Structured Forces, Structured Particles, and Synergetic Applications.

Optical manipulation has achieved great success in the fields of biology, micro/nano robotics and physical sciences in the past few decades. To date, the optical manipulation is still witnessing substantial progress powered by the growing accessibility of the complex light field, advanced nanofabrication and developed understandings of light-matter interactions. In this perspective, we highlight recent advancements of optical micro/nanomanipulations in cutting-edge applications, which can be fostered by structured optical forces enabled with diverse auxiliary multiphysical field/forces and structured particles.

Non-Ultrawide Bandgap Semiconductor GaSe Nanobelts for Sensitive Deep Ultraviolet Light Photodetector Application.

In this paper, the authors report the fabrication of a sensitive deep ultraviolet (DUV) photodetector by using an individual GaSe nanobelt with a thickness of 52.1 nm, which presents the highest photoresponse at 265 nm illumination with a responsivity and photoconductive gain of about 663 A W and 3103 at a 3 V bias, respectively, comparable to or even better than other reported devices based on conventional wide bandgap semiconductors. According to the simulation, this photoelectric property is associated with the wavelength-dependent absorption coefficient of the GaSe crystal, for which incident light with shorter wavelengths will be absorbed near the surface, while light with longer wavelengths will have a larger penetration depth, leading to a blueshift of the absorption edge with decreasing thickness.

Nanostructured multilayer hyperbolic metamaterials for high efficiency and selective solar absorption.

Highly efficient solar-to-thermal conversion is desired for the renewable energy technologies, such as solar thermo-photovoltaics and solar thermo-electric systems. In order to maximize the energy conversion efficiency, solar-selective absorbers are essential with its absorption characteristics specially tailored for solar applications. Here, we propose a wideband spectral-selective absorber based on three-dimensional (3D) nanostructured hyperbolic metamaterial (HMM), which can realize near-unity absorption across the UV and NIR spectral ranges.

Strong hyperbolic-magnetic polaritons coupling in an hBN/Ag-grating heterostructure.

Strong coupling between hyperbolic phonon-polaritons (HP) and magnetic polaritons (MP) is theoretically studied in a hexagonal boron nitride (hBN) covered deep silver grating structure. It is found that MP in grating trenches strongly interacts with HP in an anisotropic hBN thin film, leading to a large Rabi splitting with near-perfect dual band light absorption. Numerical results indicate that MP-HP coupling can be tuned by geometric parameters of the structure.

Strong coupling of optical interface modes in a 1D topological photonic crystal heterostructure/Ag hybrid system.

We theoretically investigate the strong coupling of a topological photonic state (TPS) and Tamm plasmon polaritons (TPPs) in a graphene embedded one-dimensional topological photonic crystal (TPC)/Ag structure in visible range. It is shown that the strong interaction of a TPS at the TPC heterointerface and TPP at the Ag surface enables a large Rabi splitting up to 96.8 meV with a dual-narrow-band perfect absorption.

Light Confinement Effect Induced Highly Sensitive, Self-Driven Near-Infrared Photodetector and Image Sensor Based on Multilayer PdSe /Pyramid Si Heterojunction.

In this study, a highly sensitive and self-driven near-infrared (NIR) light photodetector based on PdSe /pyramid Si heterojunction arrays, which are fabricated through simple selenization of predeposited Pd nanofilm on black Si, is demonstrated. The as-fabricated hybrid device exhibits excellent photoresponse performance in terms of a large on/off ratio of 1.6 × 10 , a responsivity of 456 mA W , and a high specific detectivity of up to 9.

Angle-independent strong coupling between plasmonic magnetic resonances and excitons in monolayer WS.

The room-temperature strong coupling between plasmonic magnetic resonances (MRs) of metal gratings and excitons in monolayer WS is intensively investigated. Both numerical simulations and theoretical calculations indicate that the strong coupling between MRs and excitons enables the remarkable spectral splitting. The typical anticrossing behavior with the Rabi splitting up to 86.

Strong longitudinal coupling of Tamm plasmon polaritons in graphene/DBR/Ag hybrid structure.

In this paper, strong longitudinal coupling of the Tamm plasmon polaritons (TPPs) is investigated in a graphene/DBR/Ag slab hybrid system. It is found that TPPs can be excited at both the top graphene and the bottom silver slab interface, which can strongly interact with each other in this coupled structure. Numerical simulation results demonstrate that the vertical Tamm plasmon coupling can be either tuned by adjusting the geometric parameters or actively controlled by the Fermi energy in graphene sheet as well as the incident angle of light, allowing for strong light-matter interaction with a tunable dual-band perfect absorption.

Dual-plasmonic Au/graphene/Au-enhanced ultrafast, broadband, self-driven silicon Schottky photodetector.

High-performance photodetectors are desirable for various applications, including multi-wavelength image sensing, communication, and safety monitoring. In this study, we report the construction of a dual-surface plasmon-enhanced silicon Schottky photodetector using Au nanoparticles (NPs)/graphene/Au NPs hybrid structure as the electrode. It was found that the as-assembled device exhibited broad sensitivity, ranging from ultraviolet to near-infrared light (360-1330 nm) at room temperature, with a high response speed of 360 ns and a 3 dB bandwidth of 780 kHz at zero bias.

Mesoporous anodic α-FeO interferometer for organic vapor sensing application.

In this work, we reported the utilization of mesoporous α-FeO films as optical sensors for detecting organic vapors. The mesoporous α-FeO thin films, which exhibited obvious Fabry-Perot interference fringes in the reflectance spectrum, were successfully fabricated through electrochemical anodization of Fe foils. Through monitoring the optical thickness of the interference fringes, three typical organic species with different vapor pressures and polarities (hexane, acetone and isopropanol) were applied as probes to evaluate the sensitivity of the α-FeO based interferometric sensor.

Numerical study on supercontinuum generation by different optical modes in AsSe-AsS chalcogenide microstructured fiber.

We investigate supercontinuum generation (SCG) in AsSe-AsS chalcogenide microstructured optical fibers (MOFs) pumped by different optical modes. The influence on SCG by different optical modes including the fundamental and high-order modes is analyzed numerically. The evolution of the supercontinuum (SC) is investigated by changing the pump wavelength (2120, 2580, and 3280 nm) and peak power (from 200 to 1000 W) of each optical mode (LP,LP,LP) in the MOFs with different fiber lengths.

Total absorption of light in monolayer transition-metal dichalcogenides by critical coupling.

Transition-metal dichalcogenides with exceptional electrical and optical properties have emerged as a new platform for atomic-scale optoelectronic devices. However, the poor optical absorption resists their potential applications. The novel method of critical coupling with guided resonances is proposed to realize total absorption of light in monolayer MoS both theoretically and numerically.

Theoretical investigation on mid-infrared cascaded Raman fiber laser based on tellurite fiber.

A numerical simulation of third-order cascaded Raman fiber laser based on tellurite fiber at the 2-5 μm waveband is presented. The Raman fiber laser can be optimized with the most suitable tellurite fiber length of 0.5-1.

Experimental investigation on supercontinuum generation by single, dual, and triple wavelength pumping in a silica photonic crystal fiber.

We investigate the supercontinuum (SC) generation in an 1 cm long silica photonic crystal fiber (PCF) pumped by the pulse sources with single, dual, and triple wavelengths, respectively. The silica PCF has two zero-dispersion wavelengths at 900 and 2620 nm, respectively. When pumped by a single wavelength, the SC spectral range covers about 1000 nm.

Hybrid tandem solar cell enhanced by a metallic hole-array as the intermediate electrode.

A metallic hole-array structure was inserted into a tandem solar cell structure as an intermediate electrode, which allows a further fabrication of a novel and efficient hybrid organic-inorganic tandem solar cell. The inserted hole-array layer reflects the higher-energy photons back to the top cell, and transmits lower-energy photons to the bottom cell via the extraordinary optical transmission (EOT) effect. In this case light absorption in both top and bottom subcells can be simultaneously enhanced via both structural and material optimizations.

Comparative research for the dietary pattern of patients with esophageal cancer at different developing stages and the daily intake of vitamin A, E and β-carotene.

This paper discusses the different stages of normal esophageal's developing to esophageal cancer, and the difference among dietary patterns of patients with esophageal cancer and acceptable daily intake of vitamin A, E and beta carotene intake in diet. This paper takes advantage of food composition table, calculates the intake amount of dietary vitamin A, E and beta carotene in all kinds of food for patients with esophageal cancer, and analyzes the intake amount difference of dietary vitamin A, E and beta carotene in each kind of food for different groups of people. Research conclusions: the low content level of dietary vitamin A, E beta-carotene and low intake amount of beans, vegetables and fruit intake may increase the risk of esophageal cancer' occurring, while the relationship among dietary vitamin E, the occurrence and development of esophageal cancer needs further discussion.

DRP-1, ezrin and E-cadherin expression and the association with esophageal squamous cell carcinoma.

It has been shown that death-associated protein kinase (DAPK) family and E-cadherin play significant roles in the promotion of apoptosis and the suppression of cell adhesion and migration, and are involved in tumor metastasis. Ezrin, a cytoplasmic peripheral membrane protein, has been shown to interact with E-cadherin to participate in the metastasis of tumor cells. The present study aimed to investigate the expression of DRP-1 (a member of the DAPK family), ezrin and E-cadherin in esophageal squamous cell carcinoma (ESCC), and to analyze their association with clinicopathological factors in order to explore their potential in ESCC diagnosis.

The effect of plasmonic nanoparticles on the optoelectronic characteristics of CdTe nanowires.

In this work, a simple strategy is proposed to improve the device performance of photodetector by modifying plasmonic nanoparticles onto the surface of semiconductors nanostructure. Both experimental analysis and theoretical simulation show that the plasmonic metal nanoparticles (AuNPs) exhibits obvious localized surface plasmon resonance (LSPR) which can trap incident light efficiently, leading to enhanced photocurrents and improved performance of photoelectronic devices. It is also observed that the AuNPs modified CdTeNW photodetector exhibit apparent sensitivity to 510 nm light, to which pure CdTeNWs is virtually blind.