Publications by authors named "Jieyi Deng"

T helper cells, particularly T follicular helper (T) cells, are essential for the neutralizing antibody production elicited by pathogens or vaccines. However, in immunocompromised individuals, the inefficient support from T cells could lead to limited protection after vaccine inoculation. Here we showed that the conjugation of inducible T cell costimulatory (ICOS) onto the nanoparticle, together with immunogen, significantly enhanced the immune response of the vaccines specific for SARS-CoV-2 or human immunodeficiency virus type-1 (HIV-1) in T-deficient mice.

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Unlabelled: The human immunodeficiency virus type 1 (HIV-1) reservoir consists of latently infected cells which present a major obstacle to achieving a functional cure for HIV-1. The formation and maintenance of HIV-1 latency have been extensively studied, and latency-reversing agents (LRAs) that can reactivate latent HIV-1 by targeting the involved host factors are developed; however, their clinical efficacies remain unsatisfactory. Therefore, it is imperative to identify novel targets for more potential candidates or better combinations for LRAs.

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Article Synopsis
  • CAR-T cell therapy shows promise in treating various cancers and diseases, but its widespread use is hindered by high costs and lengthy preparation times, as well as variability among patients.* -
  • The study aims to enhance CAR-T cell flexibility by developing modular universal CAR-T (MU-CAR-T) cells that are more stable, utilize stem cell-like T cells for better performance, and are genetically modified to reduce rejection risks.* -
  • The engineered MU-CAR-T cells effectively target and eliminate specific cells, such as HIV-infected or T lymphoma cells, and the approach offers improved production and quality control for CAR-T therapies.*
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The development of a vaccine specific to severe acute respiratory syndrome coronavirus 2 Omicron has been hampered due to its low immunogenicity. Here, using reverse mutagenesis, we found that a phenylalanine-to-serine mutation at position 375 (F375S) in the spike protein of Omicron to revert it to the sequence found in Delta and other ancestral strains significantly enhanced the immunogenicity of Omicron vaccines. Sequence FAPFFAF at position 371-377 in Omicron spike had a potent inhibitory effect on macrophage uptake of receptor-binding domain (RBD) nanoparticles or spike-pseudovirus particles containing this sequence.

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Article Synopsis
  • A new nanoparticle vaccine targeting the receptor-binding domain (RBD) of SARS-CoV-2 has been developed to provide broad protection against various sublineages, including emerging variants.
  • This vaccine induces strong neutralizing antibodies and T-cell responses, which are essential for combating respiratory infections.
  • Administered intranasally, the vaccine generates significant immune responses in the nasal passages and offers potential as a universal vaccine against multiple sarbecoviruses.
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As the global COVID-19 pandemic continues and new SARS-CoV-2 variants of concern emerge, vaccines remain an important tool for preventing the pandemic. The inactivated or subunit vaccines themselves generally exhibit low immunogenicity, which needs adjuvants to improve the immune response. We previously developed a receptor binding domain (RBD)-targeted and self-assembled nanoparticle to elicit a potent immune response in both mice and rhesus macaques.

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Article Synopsis
  • The Delta variant of SARS-CoV-2 has become the most prevalent strain globally in 2021, showing increased transmissibility and breakthrough infections among vaccinated individuals.
  • New RBD-conjugated nanoparticle vaccines have been developed to specifically target the Delta variant and other early strains, demonstrating strong immune responses in mouse models.
  • These vaccines not only generate significant neutralizing antibodies but also show potential for broader protection against various SARS-CoV-2 variants, including Omicron, indicating a promising direction for second-generation vaccine development.
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Inoculation against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is ongoing worldwide. However, the emergence of SARS-CoV-2 variants could cause immune evasion. We developed a bivalent nanoparticle vaccine that displays the receptor binding domains (RBDs) of the D614G and B.

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Various vaccine strategies have been proposed in response to the global COVID-19 pandemic, each with unique strategies for eliciting immune responses. Here, we developed nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike (S) protein. Compared to monomer vaccines, nanoparticle vaccines elicited more robust neutralizing antibodies and cellular immune responses.

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Backgrounds: Femoral head necrosis is one of the most common orthopedic diseases which can be diagnosed in all ages with different reasons. Taohong Siwu decoction (TSD) has been widely used in the treatment of femoral head necrosis. However, as far as we know, there is still a lack of supporting evidence regarding the efficacy of TSD for femoral head necrosis.

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