Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage.

Background: The role of proximal tubular autophagy in repairing kidney injury following ischemia remains unclear.

Methods: In this study, we utilized mice with conditional deletion of the Atg5 gene in proximal tubules and monitored the long-term dynamic regulation of autophagy following ischemic acute kidney injury (AKI).

Results: The results showed that Atg5-deficient proximal tubule epithelial cells exhibited damaged mitochondria, concentric membranes, and lysosomal accumulation 24 h after ischemia/reperfusion.

Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis.

Background: Autophagy is a lysosome-dependent degradation pathway that regulates macrophage activation, differentiation, and polarization. Autophagy related 5 (Atg5) is a key protein involved in phagocytic membrane elongation in autophagic vesicles that forms a complex with Atg12 and Atg16L1. Alterations in Atg5 are related to both acute and chronic kidney diseases in experimental models.

Transcriptome Analysis of Testes and Uterus: Reproductive Dysfunction Induced by in Mice.

() infection in female mammals during pregnancy can result in poor pregnancy. Similarly, it can result in male reproductive disorders in male mammals. Although the testes and uterus have very different biological makeup, they are still both attacked by resulting in reproductive dysfunctions.