Publications by authors named "Jiexiang Tian"
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, primarily characterized by chronic symmetric synovial inflammation and erosive bone destruction.Mitochondria, the primary site of cellular energy production, play a crucial role in energy metabolism and possess homeostatic regulation capabilities. Mitochondrial function influences the differentiation, activation, and survival of both immune and non-immune cells involved in RA pathogenesis.
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- Rheumatoid arthritis is an autoimmune disease affecting the bones, significantly impacting global healthcare due to its rising incidence.
- Recent research highlights the connection between gut health and the immune system's role in bone health, revealing that gut microbiota imbalances (dysbiosis) can lead to immune system issues.
- Dysbiosis triggers inflammatory responses that promote joint inflammation and damage, indicating that studying these gut-immune interactions could lead to new treatment strategies for Rheumatoid arthritis.
Article Synopsis
- Sjögren's Syndrome (SS) is an autoimmune disorder mainly affecting the salivary glands, leading to gland dysfunction and pathological changes.
- The disease involves a combination of genetic susceptibility, infections, and immune responses, with various immune cells and inflammatory mediators contributing to its progression.
- The study focuses on understanding the cellular and molecular mechanisms behind salivary gland damage in SS to propose new targeted therapies for treatment.
Rheumatoid arthritis (RA) is a most common chronic joint disease belonging to inflammatory autoimmune disease. The pathology of the disease is characterised by the infiltration and proliferation of fibroblast like synoviocytes (FLSs) and the destruction of the bone and cartilage matrix, which leads to joint dysfunction and even deformity.In recent years, an increasing number of studies have shown that MSCs have immunosuppressive properties and have been demonstrated in a variety of disease.
View Article and Find Full Text PDF[Bushentongluo recipe (BSTL) attenuates bone destruction by inhibiting NF-κB/RANK/RANKL pathway in collagen-induced arthritis (CIA) rats].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
March 2021
Objective To investigate the therapeutic effect of Bushentongluo recipe (BSTL) on bone destruction and its inhibiting effect on NF-κB/RANK/RANKL pathway in collagen-induced arthritis (CIA) rats. Methods SD rats were randomly divided into blank control group, CIA model group, methotrexate (MTX, 1 mg/kg) group, BSTL 0.5 g/kg and 2 g/kg groups, with 10 rats in each.
View Article and Find Full Text PDFBackground: Ankylosing spondylitis (AS) is a common infammatory rheumatic disease that affects the axial skeleton. Traditional Chinese medicine (TCM) nonpharmacological interventions are gaining an increasing popularity for AS. Nevertheless, the evidence of efficacy and safety of random controlled trials (RCTs) remains controversial.
View Article and Find Full Text PDFObjective: To observe influences of heat-reinforcing needling (HRN) on scores of traditional Chinese medicine (TCM) symptoms and expression of plasma ATP synthase subunit O () mRNA and lysosomal V 1 subunit B 2 () mRNA in patients with wind-cold-damp retention type rheumatoid arthritis (RA), so as to investigate its biological mechanisms in "heat production".
Methods: Sixty wind-cold-damp retention type RA patients were randomly allocated to HRN group (=30) and control group (=30). Guanyuan (CV 4), Qihai (CV 6), bilateral Zusanli (ST 36), and local acupoints near the knee-joint were selected for needling stimulation.