Publications by authors named "Jiewen Shi"
Objective: To assess the efficacy and safety of Erzhu Jiedu Decoction (EZJDD) Granules in treating mid-advanced hepatitis B virus-associated primary liver cancer (HBV-PLC) patients with Pi (Spleen)-deficiency and dampness-heat syndrome.
Methods: From January 2021 to June 2023, a cohort of 132 patients were enrolled and randomly assigned to a control group or a EZJDD group according to the random numbers, with 66 patients in each group. The patients in the control group received conventional treatment for 3 months, followed by a 3-month follow-up.
Article Synopsis
- - Liver fibrosis is a chronic condition with no effective treatments, and autophagy disruption can worsen it; this study explores Huangqi Decoction, a traditional Chinese medicine, for its effects on liver health.
- - The research found that Huangqi Decoction reduced liver injury and apoptosis in rats via tissue staining and lowered markers of fibrosis and liver damage in serum.
- - The study concluded that Huangqi Decoction promotes autophagy and inhibits apoptosis by affecting the PI3K/Akt/mTOR signaling pathway in rats suffering from liver fibrosis.
Article Synopsis
- Cholestatic liver diseases (CLD) happen when the liver has trouble making and getting rid of bile, and often the only cure is a liver transplant.
- Isoastragaloside I (IAS I), found in the Astragalus plant, can help with CLD, but scientists don’t completely understand how it works yet.
- This study tested how IAS I affects mice with CLD by looking at their blood, liver health, and other important markers, finding that IAS I improved their condition significantly.
Ethnopharmacological Relevance: Cholestatic Liver Fibrosis (CLF) is a hepatobiliary disease that typically arises as a late-stage complication of cholestasis, which can have multiple underlying causes. There are no satisfactory chemical or biological drugs for CLF. Total Astragalus saponins (TAS) are considered to be the main active constituents of the traditional Chinese herb Astragali Radix (AR), which has the obvious improvement effects for treating CLF.
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