Publications by authors named "Jieun Son"

Article Synopsis
  • Researchers have developed a stealthy neural recorder designed to monitor brain signals in non-human primates, allowing for the study of their natural behaviors.
  • The device features a fully implantable, wireless, battery-free module that records brain activity and movement, along with a flexible 32-electrode neural probe.
  • Successfully tested on a freely moving monkey, the recorder gathered data for over a month, which was then used to train an AI model to classify the animal's eating behaviors.
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  • - The electronic tongue (E-tongue) system attempts to mimic human taste perception but struggles with complex taste interactions and maintaining accurate results in variable conditions.
  • - A new artificial E-tongue system has been developed, using multiple taste sensors and a deep-learning algorithm to identify four tastes (saltiness, sourness, astringency, sweetness) and obtain taste profiles for different wines.
  • - The E-tongue system has achieved high accuracy in distinguishing between wines (about 95%) and effectively proposed a recommendation system, which improves user experience while addressing some taste assessment discrepancies.
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  • RAF protein kinases play a role in RAS activation by phosphorylating MEK, but ARAF can activate RAS independently of its kinase function.
  • ARAF binds to RAS, preventing the GTPase-activating protein NF1 from inhibiting RAS, leading to increased levels of active RAS-GTP.
  • In lung cancers with EGFR mutations, ARAF amplification contributes to resistance against EGFR inhibitors, which can be addressed by using SHP2 inhibitors to improve the effectiveness of these therapies.
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Unlabelled: In-frame insertions in exon 20 of HER2 are the most common HER2 mutations in patients with non-small cell lung cancer (NSCLC), a disease in which approved EGFR/HER2 tyrosine kinase inhibitors (TKI) display poor efficiency and undesirable side effects due to their strong inhibition of wild-type (WT) EGFR. Here, we report a HER2-selective covalent TKI, JBJ-08-178-01, that targets multiple HER2 activating mutations, including exon 20 insertions as well as amplification. JBJ-08-178-01 displayed strong selectivity toward HER2 mutants over WT EGFR compared with other EGFR/HER2 TKIs.

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  • * Researchers created a cell-based platform to test the effects of specific KRAS mutant isoforms and found that KRAS G12C and Q61H mutants responded better to MEK inhibitors compared to other isoforms.
  • * The analysis of patient data indicated that specific mutations often occur alongside others, pointing to unique gene expression patterns in different KRAS variants, suggesting that future clinical trials should categorize patients based on KRAS mutations for better treatment approaches.
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The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in -mutant non–small cell lung cancer is limited by the development of drug resistance. One mechanism of EGFR inhibitor resistance occurs through amplification of the human growth factor receptor () proto-oncogene, which bypasses EGFR to reactivate downstream signaling. Tumors exhibiting concurrent mutation and amplification are historically thought to be codependent on the activation of both oncogenes.

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Many research groups have been interested in the quartz crystal microbalance (QCM)-based gas sensors due to their superb sensitivity originated from direct mass sensing at the ng level. Despite such high sensitivities observed from QCM sensors, their ability to identify gas compounds still needs to be enhanced. Herein, we report a highly facile method that utilizes microcolumns integrated on a QCM gas-responsive system with enhanced chemical selectivity for sensing and ability to identify volatile organic compound single gases.

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Purpose: The proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%-2% of non-small cell lung cancers (NSCLC) and rarely in other cancer types. Selpercatinib is a highly selective RET kinase inhibitor that has recently been approved by the FDA in lung and thyroid cancers with activating gene fusions and mutations. Molecular mechanisms of acquired resistance to selpercatinib are poorly understood.

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Assembly of RAS molecules into complexes at the cell membrane is critical for RAS signaling. We previously showed that oncogenic KRAS codon 61 mutations increase its affinity for RAF, raising the possibility that KRAS, the most common KRAS mutation at codon 61, upregulates RAS signaling through mechanisms at the level of RAS assemblies. We show here that KRAS exhibits preferential binding to RAF relative to PI3K in cells, leading to enhanced MAPK signaling in models and human NSCLC tumors.

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Electronic wastes containing precious metals have great potential as a sustainable source of such metals. Separation and refining, however, remain complicated, and none of the existing technologies have yet experienced commercialization. A novel porphyrin-based porous polymer, named COP-180, was recently introduced as a powerful adsorbent option, especially for gold, and in this study, aspects of desorption and recovery of adsorbed gold and regeneration of the polymer were investigated.

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Semitransparent colorful organic solar cells (OSC) provide exciting opportunities for harnessing sunlight as colored windows. Previously, color filter (CF) electrodes on (OSC) were demonstrated via vacuum-deposition techniques, resulting in deposition-induced damage. Thus, we present CF integrated organic photovoltaics (CF-OPVs) using solution-processed TiO-AcAc as the dielectric component.

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Exon 20 insertion (Ex20Ins) mutations are the third most prevalent epidermal growth factor receptor (EGFR) activating mutation and the most prevalent HER2 mutation in non-small cell lung cancer (NSCLC). Novel therapeutics for the patients with Ex20Ins mutations are urgently needed, due to their poor responses to the currently approved EGFR and HER2 inhibitors. Here we report the discovery of highly potent and broadly effective EGFR and HER2 Ex20Ins mutant inhibitors.

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Human papillomavirus (HPV) is required but not sufficient for cervical carcinoma (CxCa) development. Oestradiol (E ) promotes CxCa development in K14E7 transgenic mice expressing the HPV16 E7 oncoprotein under the control of the keratin (K14) promoter. E mainly functions through oestrogen receptor α (ERα).

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In this study, electrically-facilitated forward osmosis (FO) employing proton exchange membrane (PEM) was established for the purpose of microalgae dewatering. An increase in water flux was observed when an external voltage was applied to the FO equipped with the PEM; as expected, the trend became more dramatic with both concentration of draw solution and applied voltage raised. With this FO used for microalgae dewatering, 247% of increase in flux and 86% in final biomass concentration were observed.

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Single particle Mie calculations of near micron-sized TiO particles predict strong light scattering dominating the visible range that would give rise to a white appearance. We demonstrate that a polydisperse collection of these "white" particles can result in the generation of visible colors through ensemble scattering. The weighted averaging of the scattering over the particle size distribution modifies the sharp, multiple, high order scattering modes from individual particles into broad variations in the collective extinction.

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While the function of progesterone receptor (PR) has been studied in the mouse vagina and uterus, its regulation and function in the cervix has not been described. We selectively deleted epithelial PR in the female reproductive tracts using the Cre/LoxP recombination system. We found that epithelial PR was required for induction of apoptosis and suppression of cell proliferation by progesterone (P4) in the cervical and vaginal epithelium.

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Cervical cancer is caused by human papillomavirus (HPV) in collaboration with other non-viral factors. The uterine cervix is hormone responsive and female hormones have been implicated in the pathogenesis of the disease. HPV transgenic mice expressing HPV16 oncogenes E6 (K14E6) and/or E7 (K14E7) have been employed to study a mechanism of estrogen and estrogen receptor α (ERα) in cervical carcinogenesis.

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A simple, rapid, and efficient live cell surface labeling method has been developed that uses a direct conjugation between Sortase A expressed transiently at the cell surface and Sortase A specific binding peptide.

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Human papillomavirus is the main cause of cervical cancer, yet other nonviral cofactors are also required for the disease. The uterine cervix is a hormone-responsive tissue, and female hormones have been implicated in cervical carcinogenesis. A transgenic mouse model expressing human papillomavirus oncogenes E6 and/or E7 has proven useful to study a mechanism of hormone actions in the context of this common malignancy.

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Nuclear respiratory factor-1 (NRF-1) stimulates the transcription of nuclear-encoded genes that regulate mitochondrial (mt) genome transcription and biogenesis. We reported that estradiol (E2) and 4-hydroxytamoxifen (4-OHT) stimulate NRF-1 transcription in an estrogen receptor α (ERα)- and ERβ-dependent manner in human breast cancer cells. The aim of this study was to determine whether E2 and 4-OHT increase NRF-1 in vivo.

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cAMP-response-element-binding protein (CREB) signaling has been reported to be associated with cancer development and poor clinical outcome in various types of cancer. However, it remains to be elucidated whether CREB is involved in breast cancer development and osteotropism. Here, we found that metastatic MDA-MB-231 breast cancer cells exhibited higher CREB expression than did non-metastatic MCF-7 cells and that CREB expression was further increased by several soluble factors linked to cancer progression, such as IL-1, IGF-1, and TGF-beta.

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Objective: Cervical cancer is the second most frequent cancer among women in Busan. The Pap smear test could have a significant effect on detecting cervical cancer, and enhancing their rate of use is an important strategy for reducing the incidence and mortality of cervical cancer. This study aimed to evaluate the factors associated with the past use of the Pap smear test in Korean women.

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