Publications by authors named "Jieun Seon"
J Neurooncol
December 2022
Article Synopsis
- Limited treatment options for glioblastoma (GBM) highlight the potential for targeting cancer-specific metabolic pathways by inhibiting key enzymes CPT1A and G6PD, which are vital for fatty acid oxidation and the pentose phosphate pathway.
- Experiments demonstrated that knocking down CPT1A and G6PD reduced GBM tumor cell viability and growth, supported by transcriptome analysis and metabolite profiling indicating disrupted metabolic pathways.
- The combination therapy using etomoxir and DHEA not only inhibited tumor growth in cell cultures but also extended survival in mice models, suggesting a promising therapeutic strategy for GBM.
