Pentacyclic triterpenoids with cytotoxic activity from the stems of Syzygium jambos (L.) Alston.

Phytochemical investigation of the stems of Syzygium jambos (L.) Alston resulted in the isolation of five new pentacyclic triterpenoids, including three oleananes (1, 2, and 5) and two ursanes (3 and 4), along with 23 known compounds (6-28). Their structures were elucidated by comprehensive spectroscopic analysis and chemical methods.

Research on Integrated Management Path of Comorbidity Based on Grounded Theory.

Background: This study seeks to thoroughly investigate the generation mechanism of the integrated management pathway for comorbidities, as well as its implementation and execution in practical settings. The findings aim to offer insights for the development of an integrated mechanism for comorbidity services.

Method: The collected raw data was coded and analyzed in depth by utilizing grounded theory as the research methodology, in conjunction with NVivo 14.

A study on regional differences and convergence of nursing human resource levels in the Yangtze River Economic Belt: an empirical study.

Background: The Yangtze River Economic Belt, as a core economic region in China, is facing the dual challenges of an aging population and growing healthcare demand, and the balanced development and optimal allocation of nursing human resources is crucial to the region's healthcare system. An in-depth study of the regional differences and convergence of nursing human resources in the region will provide a key basis for policy makers to achieve equity and efficiency in healthcare services and meet the growing demand for healthcare.

Aim: To analyze the regional differences and convergence characteristics of nursing human resource levels in the Yangtze River Economic Belt, and to provide scientific references for optimizing regional nursing human resource allocation.

The impact of the scale and hierarchical structure of health human resources on the level of medical services-based on China's four major economic regions.

Background: Ensuring that the scale and hierarchical structure of health human resources are rational, and that medical services are efficient and fair, is an important task of practical significance. On this basis, examining the impact of health human resources on the level of medical services presents a new and formidable challenge. This study aims to delve into how the scale and hierarchical structure of health human resources in China's four major economic regions affect the fairness and efficiency of medical services, and to identify optimization strategies.

Research on the coupling measurement of medical education and health resource allocation under the background of healthy China.

Objective: To analyze the coupling and coordination level of medical education and health resource allocation in China, and to provide scientific basis for promoting the high-quality development of medical education and the efficient allocation of health resources.

Methods: Based on the panel data from 2011 to 2021, the coupling coordination degree model was used to measure the coupling coordination index of medical education and health resources in China. The spatial auto-correlation model was used to analyze the development status and distribution characteristics of the coupling coordination degree of the two systems.

CD317 MSCs expanded with chemically defined media have enhanced immunological anti-inflammatory activities.

Background: Although both preclinical and clinical studies have shown the great application potential of MSCs (mesenchymal stem/stromal cells) in treating many kinds of diseases, therapeutic inconsistency resulting from cell heterogeneity is the major stumbling block to their clinical applications. Cell population diversity and batch variation in the cell expansion medium are two major inducers of MSC heterogeneity.

Methods: Cell population diversity was investigated through single-cell RNA sequencing analysis of human MSCs derived from the umbilical cord and expanded with fully chemically defined medium in the current study.

Virtual screening combined with experimental verification reveals the potential mechanism of Fuzitang decoction against Gouty Arthritis.

Background: and Purpose: Fuzitang decoction (FZT), a classic prescription of traditional Chinese medicine (TCM), has excellent efficacy in treating gouty arthritis (GA). However, the underlying molecular mechanism remains obscure. In the present study, we aimed to explore the underlying mechanisms of FZT in treating GA by virtual screening combined with experimental verification.

Genome-wide characterization of regulator of chromosome condensation 1 (RCC1) gene family in Artemisia annua L. revealed a conservation evolutionary pattern.

Background: Artemisia annua is the major source for artemisinin production. The artemisinin content in A. annua is affected by different types of light especially the UV light.

Exposure to irregular microplastic shed from baby bottles activates the ROS/NLRP3/Caspase-1 signaling pathway, causing intestinal inflammation.

Irregularly shaped microplastics (MPs) released from infant feeding bottles (PP-IFBs) may exhibit increased cytotoxicity, in contrast to the commonly studied spherical MPs. This study presents an initial analysis of the thermal-oxidative aging process of plastic shedding from feeding bottles, and investigates the inflammatory response induced by these atypical MPs in human intestinal cells (Caco-2). The PP-IFBs' surface displayed non-uniform white patches and increased roughness, revealing substantial structural alteration and shedding, especially during actions such as shaking, boiling water disinfection, and microwave heating.

Correlating metasurface spectra with a generation-elimination framework.

Inferring optical response from other correlated optical response is highly demanded for vast applications such as biological imaging, material analysis, and optical characterization. This is distinguished from widely-studied forward and inverse designs, as it is boiled down to another different category, namely, spectra-to-spectra design. Whereas forward and inverse designs have been substantially explored across various physical scenarios, the spectra-to-spectra design remains elusive and challenging as it involves intractable many-to-many correspondences.

Investigating Acupoint Selection and Combinations of Acupuncture for Tic Disorders: An Association Rule Mining and Network Analysis Study.

Objective: Tic disorders (TDs) are common mental disorders in children and adolescents, and the clinical application of acupuncture for treating TDs is becoming increasingly widespread. However, the criteria for selecting acupoint prescriptions and combinations have not been summarized. Therefore, data mining was used herein to determine the treatment principles and the most effective acupoint selection and compatibility criteria for the treatment of TDs.

Assessment of Cone-Beam Breast Computed Tomography for Predicting Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Prospective Study.

Background: Response surveillance of neoadjuvant chemotherapy is needed to facilitate treatment decisions. We aimed to assess the imaging features of cone-beam breast computed tomography (CBBCT) for predicting the pathologic response of breast cancer after neoadjuvant chemotherapy.

Methods: This prospective study included 81 women with locally advanced breast cancer who underwent neoadjuvant chemotherapy from August 2017 to January 2021.

Toxic effects of microplastics in plants depend more by their surface functional groups than just accumulation contents.

Differentially charged microplastics (MPs) engendered by plastic aging (e.g., plastic film) widely existed in the agricultural ecosystem, yet minimal was known about the toxic effects of MPs on plants and their absorption and accumulation characteristics.

Correlation between contrast-enhanced cone-beam breast computed tomography features and prognostic staging in breast cancer.

Objective: To evaluate whether contrast-enhanced cone-beam breast CT (CE-CBBCT) features can risk-stratify prognostic stage in breast cancer.

Methods: Overall, 168 biopsy-proven breast cancer patients were analysed: 115 patients in the training set underwent scanning using v. 1.

Intravoxel Incoherent Motion Diffusion-Weighted Imaging for Quantitative Differentiation of Breast Tumors: A Meta-Analysis.

The diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in the differential diagnosis of breast tumors remains debatable among published studies. Therefore, this meta-analysis aimed to pool relevant evidence regarding the diagnostic performance of IVIM-DWI in the differential diagnosis of breast tumors. Studies on the differential diagnosis of breast lesions using IVIM-DWI were systemically searched in the PubMed, Embase and Web of Science databases in recent 10 years.

Differentiating the lung lesions using Intravoxel incoherent motion diffusion-weighted imaging: a meta-analysis.

Background And Objectives: The diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in the differential diagnosis of pulmonary tumors remained debatable among published studies. This study aimed to pool and summary the relevant results to provide more robust evidence in this issue using a meta-analysis method.

Materials And Methods: The researches regarding the differential diagnosis of lung lesions using IVIM-DWI were systemically searched in Pubmed, Embase, Web of science and Wangfang database without time limitation.

Cost-effective storage solution for delivering umbilical cord with efficient isolation of mesenchymal stem cells.

Mesenchymal stem cells (MSCs) represent a promising therapeutic candidate for treating many diseases. However, their proliferation and therapeutic abilities decline during the aging process and disease development. Therefore, fetal MSCs derived from the umbilical cord (UC) attract more attention.

Chemical-defined medium supporting the expansion of human mesenchymal stem cells.

Objectives: Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been developed yet.

Materials And Methods: Here, we developed the full chemical-defined medium, NBVbe medium, via RNA sequencing, bioinformatic analysis, and growth factor screening.

Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus.

Background: Although mesenchymal stem cells (MSCs) might offer a promising strategy for treating SLE, their immunoregulatory plasticity makes their therapeutic effects unpredictable. Whether overexpressing IL-37, an IL-1 family member with immunosuppressive activity, might enhance the therapeutic effects of these cells for SLE is unknown.

Methods: We genetically modified MSCs to overexpress IL-37 and assessed their effects on immune suppression .

Rapid identification of genome-edited mesenchymal stem cell colonies via Cas9.

Mesenchymal stem cells (MSCs) have been intensively investigated and widely applied in regenerative medicine and immune modulation. However, their efficacy declines during the aging or disease process. Thus, genome-edited MSCs with over-expression or inhibition of specific genes hold a great deal of promise in terms of their therapeutic application.

[The Expression of microRNA-221 in Endometriosis and Its Impact on Endometrial Stromal Cells].

Objective: To determine the expression of microRNA-221 (miR-221) in endometrial tissues and its impact on the proliferation of ectopic endometrial stromal cells.

Methods: Endometrial stromal cells were isolated, cultured and identified from normal endometrial tissues (taken from patients without endometriosis) and ectopic endometrial tissues (taken from patients with ovarian endometriosis). The expression of microRNA-221 was detected by stem-loop qRT-PCR.

Updated incidence rates and risk factors of esophageal cancer in Nan'ao Island, a coastal high-risk area in southern China.

Esophageal cancer (EC) is one of the most common cancers in China. The purpose of this study was to investigate the updated incidence rates and risk factors of EC in Nan'ao Island, where the EC incidence rate was chronically the highest in southern China. To calculate the annual incidence rate, data on 338 EC cases from Nan'ao Cancer Registry system diagnosed during 2005-2011 were collected.