PM promotes replication of VSV by ubiquitination degradation of phospho-IRF3 in A549 cells.

Both PM and respiratory viruses are part of the atmospheric constituents. Respiratory viruses are often associated with PM exposure, but the mechanism of toxicity remains to be explored. The vitro models that adequately reproduce healthy cells or diseased cells exposing to PM and infecting VSV can provide a useful tool for studying innate immune mechanisms and investigating new therapeutic focus.

Toxoplasma gondii Cathepsin C1 inhibits NF-κB signalling through the positive regulation of the HIF-1α/EPO axis.

Toxoplasma gondii has evolved many successful strategies for immune evasion. However, the parasite-derived effectors involved in modulating NF-κB signalling pathway are largely unknown. T.

Experimental study of blood pressure and its impact on spontaneous hypertension in rats with Xin Mai Jia.

Aim: The aim of this study was to evaluate the antihypertensive effect of Xin Mai Jia (XMJ) and to explore the mechanism of its hypotensive effect.

Methods: A total of 50 spontaneously hypertensive rats (SHR) were randomised into five groups. A total of 30 Wistar-Kyoto rats were randomised into three groups, comprising the control group.