Glycemic traits are critical indicators of maternal and fetal health during pregnancy. We performed genetic analysis for five glycemic traits in 14,744 Chinese pregnant women. Our genome-wide association study identified 25 locus-trait associations, including established links between gestational diabetes mellitus (GDM) and the genes CDKAL1 and MTNR1B.
View Article and Find Full Text PDFResidual normal plasma cells (NPCs), which compete with tumor plasma cells, play an important role in multiple myeloma. However, large-scale cohort studies investigating residual NPCs, especially at the minimal residual disease (MRD) phase, are currently lacking. In this study, we conducted a comprehensive investigation into the clinical significance of residual NPCs throughout the entire disease course in 1363 myeloma patients from the NICHE cohort (NCT04645199).
View Article and Find Full Text PDFBackground: Limited evidence exists regarding the association between gestational diabetes mellitus (GDM) and elevated levels of thyroid-stimulating hormone (TSH) in newborns. Therefore, this study aimed to investigate the potential risk of elevated TSH levels in infants exposed to maternal GDM, considering the type and number of abnormal values obtained from the 75-gram oral glucose tolerance test (OGTT).
Methods: A population-based, prospective birth cohort study was conducted in Wuhan, China.
Background: Women with multiple pregnancies are vulnerable to experience postpartum depression (PPD). Emerging evidence indicates an association between poly- and perfluoroalkyl substances (PFAS) exposure and PPD in women delivering singletons. The health risks of PFAS may also be present in women delivering twins.
View Article and Find Full Text PDF: Protein powder has attracted attention due to its possible adverse effects. We aimed to investigate the association of protein powder supplementation in early pregnancy with gestational diabetes mellitus (GDM) risk. : We included 6897 participants with singleton pregnancies from a prospective birth cohort.
View Article and Find Full Text PDFBackground: Environmental inorganic arsenic (iAs) exposure is potentially related to abnormal blood pressure (BP) changes and abnormal platelet activation. However, limited epidemiological studies have explored the impacts of iAs exposure on platelet change mediated by BP, especially for pregnant women.
Objectives: Our purpose was to investigate the associations of arsenic exposure with blood pressure and platelet indices among pregnant women.
Dimethyl phthalate (DMP), a low-molecular-weight phthalate ester, exists in ectoparasiticides, plastics, and insect repellants, and has been linked to neurotoxic, reproductive, and endocrine disruptive responses. However, its blood immunotoxic effects and mechanism are still poorly understood. In this study, rats were exposed to gradient concentrations of DMP through intragastric administration to assess the blood immunotoxic effects in the combined assay of biomarker, cytometry, and transcriptomics.
View Article and Find Full Text PDFThe putty polishing procedure usually produces a large number of micron-sized particles, which can lead to serious respiratory diseases as well as skin conditions. The diagonal ventilation system is widely used to decrease the particle concentration in different environments. However, it becomes less effective for a large empty factory workshop, such as the polishing workshop for high-speed rail carriages, in which the diagonal ventilation mode usually results in turbulence in the airflow.
View Article and Find Full Text PDFObjective: Childhood obesity is a major health concern worldwide. Previous studies have explored the relationship between obesity and gut microbiota. However, the results from such studies remain contradictory.
View Article and Find Full Text PDFPesticide residue in vegetables has been considered as a serious food safety problem across the whole world. This study investigates a novel advanced oxidation process (AOP), namely the coupled free chlorine/ultrasound (FC/US) process for the removal of three typical pesticides from lettuce. The removal efficiencies of dimethoate (DMT), trichlorfon (TCF) and carbofuran (CBF) from lettuce reached 86.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
March 2022
As an advanced oxidation process, vacuum ultraviolet/ultraviolet (VUV/UV) has been intensively studied for drinking water treatment, but assessment of its feasibility for wastewater treatment has rarely been conducted. This study investigated the treatment of fluorine-containing pharmaceutical wastewater by VUV/UV process and examined the defluorination and therefore the improvement of biodegradability of the wastewater after the process. The results indicated that the degradation of a model fluorine-containing organic compound (namely, 4-fluorophenol) was mainly achieved via the attack of the fluorine atom linking directly to the aromatic ring by the HO generated from VUV photolysis of water.
View Article and Find Full Text PDFWe used a transparent systematic review framework based on best practices for evaluating study quality and integrating evidence to conduct a review of the available epidemiology studies evaluating associations between long-term exposure to ambient concentrations of PM and mortality (all-cause and non-accidental) conducted in North America. We found that while there is some consistency across studies for reporting positive associations, these associations are weak and several important methodological issues have led to uncertainties with regard to the evidence from these studies, including potential confounding by measured and unmeasured factors, exposue measurement error, and model misspecification. These uncertainties provide a plausible, alternative explanation to causality for the weakly positive findings across studies.
View Article and Find Full Text PDFEnvironmental exposures are one of the greatest threats to human health, yet we lack tools to answer simple questions about our exposures: what are our personal exposure profiles and how do they change overtime (external exposome), how toxic are these chemicals, and what are the sources of these exposures? To capture variation in personal exposures to airborne chemicals in the gas and particulate phases and identify exposures which pose the greatest health risk, wearable exposure monitors can be deployed. In this study, we deployed passive air sampler wristbands with 84 healthy participants (aged 60-69 years) as part of the Biomarkers for Air Pollutants Exposure (China BAPE) study. Participants wore the wristband samplers for 3 days each month for five consecutive months.
View Article and Find Full Text PDFThe ongoing SARS-CoV-2 pandemic infecting millions of people globally has given rise to serious public health threats. The need for early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic pregnant women is compelling to detect vertical transmission timely. Here, 11 SARS-CoV-2 asymptomatic pregnant cases from Wuhan China were investigated.
View Article and Find Full Text PDFObjective: Ovarian cancer (OC) affects nearly 22,000 women annually in the United States and ranks fifth in cancer deaths, largely because of being diagnosed at an advanced stage. Autophagy is the cellular process of self-degrading damaged or degenerate proteins and organelles. Long non-coding RNAs (lncRNAs) are a group of RNA molecules whose transcripts are greater than 200 nt but are not translated into proteins.
View Article and Find Full Text PDFBackground: The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and the risk of adverse birth outcomes.
Method: We conducted a retrospective cohort study based on the Maternal and Child Health Information System (MCHIMS) of Wuhan, China.
Spectrochim Acta A Mol Biomol Spectrosc
January 2021
Rational design of detection strategy is the key to high-performance fluorescence analysis. In this article, we found that the glucose-induced limitations can greatly enhance the fluorescence of functionalized carbon nanoparticles (CNPs), which are synthesized through one-step thermal pyrolysis method using phenylboronic acid derivative as the precursors. The glucose can assembly onto the surface of the CNPs to form a "shell", limiting the surfaces' intramolecular rotation and reducing non-radiative decay, which hence resulted in enhanced fluorescence of the CNPs.
View Article and Find Full Text PDFOver the past 60 years, because of the combined impacts of human activities and climate change, the sediment load of the nine major rivers (the Yellow, Yangtze, Pearl, Songhuajiang, Liaohe, Haihe, Huaihe, Qiantangjiang, and Minjiang rivers) in China has dropped by 85%, which had caused serious environmental problems such as reservoir siltation and estuary erosion. However, quantitatively evaluating the impact of different human activities on this decline is still an unsolved and complex problem. Based on a big new data set from 27 gauge stations and 469 meteorological stations, we established five methods to assess sediment loss of China's nine major rivers.
View Article and Find Full Text PDFBackground: Maternal hypertensive disorders of pregnancy (HDP) are the major causes of maternal mortality. However, the association between HDP and offspring's neurodevelopment remains unclear.
Method: Participants were 4031 singleton live births from a prospective cohort study in Wuhan, China, during October 2013 to October 2014.
BACKGROUND Polycystic ovarian syndrome (PCOS) is a common endocrine disorder causing infertility among reproductive-age women. The molecular mechanisms underlying the development of PCOS are not well understood, and effective treatment options and therapeutic targets for PCOS are not available. This study was designed to investigate the role and therapeutic potential of miR-324 in PCOS.
View Article and Find Full Text PDFFormaldehyde has become a ubiquitous contaminant in the air, and people are exposed to it worldwide. However, few studies have evaluated the temporal-spatial levels/changes of formaldehyde exposure at residences, and the relationship between its outdoor and indoor levels has been rarely examined. The aim of this study was to assess community formaldehyde exposure in Sebes and Aiud, Romania to identify: (1) home environment characteristics that may play an important role in exposure; and understand: (2) if there were differences in formaldehyde levels between the two cities; (3) if there were temporal variations within each city; and (4) whether outdoor formaldehyde levels influence indoor levels.
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