Enhancing in-situ updates of quantized memristor neural networks: a Siamese network learning approach.

Brain-inspired neuromorphic computing has emerged as a promising solution to overcome the energy and speed limitations of conventional von Neumann architectures. In this context, in-memory computing utilizing memristors has gained attention as a key technology, harnessing their non-volatile characteristics to replicate synaptic behavior akin to the human brain. However, challenges arise from non-linearities, asymmetries, and device variations in memristive devices during synaptic weight updates, leading to inaccurate weight adjustments and diminished recognition accuracy.

Mesoporous PtIr alloy single-particle: A novel SECM-tip for in situ monitoring NO of single-cell.

As a vital factor in cell metabolism, nitric oxide (NO) is associated with nitrosative stress and subsequent inflammations and diseases. In situ, real-time NO monitoring is challenging due to its relative trace concentration and fast diffusion in cell. Scanning electrochemical microscopy (SECM) is suited uniquely for single-cell analysis, and its electrochemical response to targets can be further enhanced by improving the interfacial properties of its tip.

Investigation of G-Quadruplex DNA-Mediated Charge Transport for Exploring DNA Oxidative Damage in Telomeres.

The human telomeric DNA 3' single-stranded overhang comprises tandem repeats of the sequence d(TTAGGG), which can fold into the stable secondary structure G-quadruplex (G4) and is susceptible to oxidative damage due to the enrichment of G bases. 8-Oxoguanine (8-oxoG) formed in telomeric DNA destabilizes G4 secondary structures and then inhibits telomere functions such as the binding of G4 proteins and the regulation of the length of telomeres. In this work, we developed a G4-DNA self-assembled monolayer electrochemical sensing interface using copper-free click chemistry based on the reaction of dibenzocyclooctyl with azide, resulting in a high yield of DNA tethers with order and homogeneity surfaces, that is more suitable for G-quadruplex DNA charge transport (CT) research.

An isolated single-particle-based SECM tip interface for single-cell NO sensing.

As a key factor in cellular metabolic processes, nitric oxide (NO) is a challenging target for in situ real-time monitoring due to its transient property and short diffusion distance. Scanning electrochemical microscopy (SECM) has unique advantages in single-cell analysis, which can obtain the electrochemical current by scanning the cell surface with a tip microelectrode. In particular, it can further improved the electrochemical response by enhancing the interface properties of its tip.

Interlayer impacts to deep-coupling dynamical networks: A snapshot of equilibrium stability.

This paper defines deep-coupling networks with two categories of interlayer structures and investigates the equilibrium stability, when every node in the network is governed by a differential dynamical system. Several stability criteria of the equilibrium of deep-coupling networks are arrived at when the equilibrium of each node system is stable or unstable in two categories of interlayer couplings, which clarify interlayer impacts with the dependence of network topology and intralayer intensity as well. Several two-layer and three-layer numerical examples are provided to verify the analytical results.