The effect of the 5-HT2A/2C receptor agonist DOI on micturition in rats with chronic spinal cord injury.

Purpose: We examined the effects of the 5-HT2A/2C receptor agonist DOI on micturition in chronic spinal cord injured rats.

Materials And Methods: Female Sprague-Dawley® rats were used. Spinal cord injury was produced by transection at the T10 level.

Improving voiding efficiency in the diabetic rat by a 5-HT1A serotonin receptor agonist.

Aims: Serotonin affects micturition in the normal rat through actions not only on ascending and descending spinal pathways and supraspinal centers but also on the lumbosacral spinal cord level. The selective 5-HT1A receptor agonist, 8-OH-DPAT((R)-(+)-8-hydroxy-2-(di-n-propylamino) tetralin), reversed detrusor-sphincter dyssynergia (DSD) in the spinal cord injury (SCI) rat. Rats with experimental diabetes mellitus (DM) have been shown to have both bladder and urethral dysfunction during reflex voiding.