: A high-throughput tool for alignment-free phylogenetics.

Phylogenetic tools are fundamental to the studies of evolutionary relationships. In this paper, we present , a novel high-throughput tool for alignment-free phylogenetic analysis. computes the pairwise distance matrix between molecular sequences, using seven widely accepted -mer based distance measures.

The downregulation of ANGPTL4 inhibits the migration and proliferation of tongue squamous cell carcinoma.

Objective: Tongue squamous cell carcinoma (TSCC) is the most common malignant cancer in the oral cavity, with a high rate of metastasis to the neck lymphoid node. Angiopoietin-like protein 4 (ANGPTL4) and microvessel density (MVD) may be novel indicators for tumor metastasis. The aim of the present study was to investigate the expression and function of ANGPTL4 in TSCC and the relationship between ANGPTL4 and MVD.

A two-dimensional model on the coupling thickness-shear vibrations of a quartz crystal resonator loaded by an array spherical-cap viscoelastic material units.

We establish a two-dimensional model on the coupling thickness-shear mode (TSM) vibrations of a quartz crystal resonator (QCR) carrying an array of spherical-cap (SC) viscoelastic material units. The electrical admittance of the compound QCR system is described directly in terms of the physical properties of the surface material units. The admittance spectra about the tendon stem cells (TSCs) acquired from our calculation are compared with the existing experiment data and found to be consistent with each other, indicating our model has good veracity and reliability in analyzing the mechanical properties of covered loadings.

Frequency shift of a crystal quartz resonator in thickness-shear modes induced by an array of hemispherical material units.

A two-dimensional model was established to study the dynamic characteristics of a quartz crystal resonator with the upper surface covered by an array of hemispherical material units. A frequency-dependent equivalent mass ratio was proposed to simulate the effect of the covered units on frequency shift of the resonator system. It was found that the equivalent mass ratio alternately becomes positive or negative with change of shear modulus and radius of each material unit, which indicates that the equivalent mass ratio is strongly related to the vibration mode of the covered loadings.