Publications by authors named "Jiemeng Zhang"
Article Synopsis
- The study investigates how the removal of oncoproteins in liver cells affects the development of liver cancer (HCC) induced by the chemical diethylnitrosamine (DEN).
- Researchers created mutant mouse models to analyze how the absence of specific genes (Met, Ptpn11/Shp2, Ikkβ, and Ctnnb1/β-catenin) altered tumor development and performed extensive genetic testing on liver samples.
- Findings indicate that removing oncoproteins increases genetic mutations and alters important signaling pathways linked to cancer progression, highlighting complex mechanisms in liver tumor development and recurrence.
Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages.
Cell Mol Gastroenterol Hepatol
May 2023
Background & Aims: Complex communications between hepatocytes and Kupffer cells (KCs) are known to drive or suppress hepatocarcinogenesis, with controversial data in the literature. In previous experiments that aimed to decipher hepatocyte/KC interactions, we unexpectedly unveiled a tumor-suppressing effect of polyinosinic-polycytidylic acid, a widely used inducer of MX dynamin like GTPase 1 (Mx1)-cre expression, which questioned a theory of interleukin 1a/6 cytokine circuit in hepatocyte/KC communication. The goal of this study was to clarify the controversy and decipher unique functions of KCs and non-KC macrophages in liver tumorigenesis.
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