Publications by authors named "Jiemei Jiang"
Article Synopsis
- Histone modifications (HMs) are important for plant growth and stress resistance, but their identification in medicinal plants like Aquilaria sinensis is limited, prompting this comprehensive study that identified 123 HMs.
- The research included evolutionary and functional analyses, including phylogenetic tree construction and the exploration of gene functions, to understand how these HMs might relate to agarwood formation and stress responses.
- Findings indicated that specific HMs are likely involved in the synthesis of agarwood compounds, supported by qRT-PCR analysis and RNA interference experiments, providing insight into epigenetic regulation in plants.
Dracaena, a remarkably long-lived and slowly maturing species of plant, is world famous for its ability to produce dragon's blood, a precious traditional medicine used by different cultures since ancient times. However, there is no detailed and high-quality genome available for this species at present; thus, the molecular mechanisms that underlie its important traits are largely unknown. These factors seriously limit the protection and regeneration of this rare and endangered plant resource.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses the significance of a non-timber tree species that produces valuable agarwood, which is used in traditional medicine and incense, and notes that agarwood forms in response to tree injuries and fungal infections.
- The study identifies 119 transcription factor genes, organizes them into various subfamilies, and characterizes their structures and locations, including specific stress-related motifs.
- Eleven highly expressed genes linked to agarwood production were analyzed for their responses to treatments like methyl jasmonate and salt, revealing significant upregulation, which helps to understand gene functions and regulatory roles in agarwood formation.
Anlotinib is a small molecular multi-targeting tyrosine kinase inhibitor. Growing evidence indicates that treatment efficacy, and toxicity varies considerably between individuals. Therefore, this study aimed to investigate the relationship between cytochrome P450 (CYP450) gene polymorphisms, drug concentrations, and their adverse reactions in anlotinib-treated patients with lung cancer.
View Article and Find Full Text PDFThe improvement of the harvest period standards is critical in the quality control of Chinese medicinal materials. The present study statistically analyzed the harvest period standards of plant medicinal materials in the 2020 edition of Chinese Pharmacopoeia(Vol.Ⅰ) and put forward the existing problems and suggestions based on herbal records and modern research to provide references for the improvement of the standards.
View Article and Find Full Text PDFA The complete chloroplast genome and phylogenetic analysis of Bupleurum yinchowense Shan & Yin Li.
Mitochondrial DNA B Resour
March 2021
Shan & Yin Li was first described as a new species in 1974, but its classification status has always been disputed. Here, its complete chloroplast genome was provided to resolve this issue. The length of the chloroplast genome is 155,851 bp and composed of two inverted repeats (IR: 26,307 bp), a large single-copy region (LSC: 85,625 bp), and a small single-copy region (SSC: 17,612 bp).
View Article and Find Full Text PDFThe root of var. (H. Wolff) Shan & Yin Li (Apiaceae), a new substitution for the popular Chinese medicinal material, Bupleuri Radix (Chai hu), is not easily distinguishable via traditional methods.
View Article and Find Full Text PDFThe α9α10 nicotinic acetylcholine receptor (nAChR) is an effective therapeutic target for neuropathic pain. α-Conotoxin RgIA and Vc1.1 are two well-known peptides blocking α9α10 nAChR potently and selectively, which have been extensively investigated as drug candidates.
View Article and Find Full Text PDFBackground: Hypertrophic scar is a fibro-proliferative disease. Our previous studies demonstrate that compound Astragalus and Salvia miltiorrhiza extract (CASE) inhibits proliferation and invasion in keloid fibroblasts.
Objective: To investigate the effects of CASE on hypertrophic scar.
Background And Aim: Previous studies showed Compound Astragalus and Salvia miltiorrhiza extract (CASE), extract from Astragalus membranaceus and Salvia miltiorhiza, significantly suppresses hepatocellular carcinoma (HCC) in rats induced by diethylinitrosamine (DEN), and in vitro experiments further demonstrated that CASE's anti-HepG2 cell invasion is associated with transforming growth factor-β (TGF-β). We hypothesized that CASE's suppression of HCC is modulated by TGF-β/Smad signaling, and we conducted this in vivo study to test this hypothesis.
Methods: Rats were divided into the normal control, the DEN group, and three CASE (60, 120, and 240 mg/kg) treatment groups.