Inverse-free zeroing neural network for time-variant nonlinear optimization with manipulator applications.

In this paper, the problem of time-variant optimization subject to nonlinear equation constraint is studied. To solve the challenging problem, methods based on the neural networks, such as zeroing neural network and gradient neural network, are commonly adopted due to their performance on handling nonlinear problems. However, the traditional zeroing neural network algorithm requires computing the matrix inverse during the solving process, which is a complicated and time-consuming operation.

A naturally isolated symbiotic bacterium suppresses flavivirus transmission by mosquitoes.

The commensal microbiota of the mosquito gut plays a complex role in determining the vector competence for arboviruses. In this study, we identified a bacterium from the gut of field mosquitoes named sp. YN46 (YN46) that rendered mosquitoes refractory to infection with dengue and Zika viruses.

Leveraging Representation Learning for the Construction and Application of a Knowledge Graph for Traditional Chinese Medicine: Framework Development Study.

Background: Knowledge discovery from treatment data records from Chinese physicians is a dramatic challenge in the application of artificial intelligence (AI) models to the research of traditional Chinese medicine (TCM).

Objective: This paper aims to construct a TCM knowledge graph (KG) from Chinese physicians and apply it to the decision-making related to diagnosis and treatment in TCM.

Methods: A new framework leveraging a representation learning method for TCM KG construction and application was designed.

Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy.

Sphingosine-1-phosphate (S1P) has been shown to possess pro-hypertrophic properties in the heart, but the detailed molecular mechanism that underlies the pathological process is rarely explored. In the present study, we aim to explore the role of S1P-mediated intracellular Ca signaling, with a focus on sarcoplasmic reticulum (SR)-mitochondria communication, in cardiomyocyte hypertrophy. Cultured neonatal rat ventricular myocytes (NRVMs) displayed significantly hypertrophic growth after treatment with 1 μmol/L S1P for 48 h, as indicated by the cell surface area or mRNA expressions of hypertrophic marker genes (ANP, BNP and β-MHC).