Publications by authors named "Jiejun Liu"
Numerous contemporary diseases are linked to food contamination. Pathogenic agents might stem from certain food ingredients or result from pollution stemming from food processing or packaging. One such contaminant is 3-Chloro-1,2-propanediol (3-MCPD), it has been previously reported to be produced during the preparation of chemical sauces, as well as during the heating of baked goods.
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- Environmental pollution, particularly drug contamination, poses significant risks, with pharmaceutical compounds like Isavuconazonium sulfate (ISAV-SF) being detected in aquatic ecosystems at toxic levels.
- This study uses zebrafish to investigate the cardiotoxic effects of ISAV-SF, finding that exposure leads to serious heart development issues and disrupts key cardiac genes and signaling pathways.
- The antioxidant astaxanthin shows potential in reducing oxidative stress and improving heart development, highlighting the need for tighter regulations on ISAV-SF to protect aquatic life.
Dimethyl fumarate (DMF) is an immunosuppressant commonly used to treat multiple sclerosis and other autoimmune diseases. Despite known side effects such as lymphopenia, the effect of DMF on cardiac development remains unclear. To assess this, we used zebrafish to evaluate the cardiac developmental toxicity of DMF.
View Article and Find Full Text PDFBPA induces hepatotoxicity in zebrafish through oxidative stress and apoptosis pathways.
Fish Physiol Biochem
April 2024
BPA is so ubiquitous that 27 million tons of BPA-containing plastic, including mineral water bottles and baby bottles, is produced worldwide each year. The potential toxicity of BPA to humans and aquatic organisms has been the subject of intense research. In this study, a zebrafish model system was used to assess BPA-mediated hepatotoxicity.
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- Apatinib is a VEGFR2-tyrosine kinase inhibitor known for its effectiveness in cancer treatment but also causes various side effects, necessitating research on its toxicity and mechanism.
- In a study using zebrafish, exposure to different concentrations of apatinib resulted in harmful developmental effects, including liver damage, body length reduction, and elevated oxidative stress levels.
- The findings suggest that apatinib might cause liver toxicity by inhibiting the Wnt signaling pathway and increasing oxidative stress, indicating the need for careful clinical use of the drug.
Cyclosporine A induces hepatotoxicity in zebrafish larvae via upregulating oxidative stress.
Comp Biochem Physiol C Toxicol Pharmacol
April 2023
As a powerful immunosuppressant, cyclosporine A (CsA) is widely used clinically. However, it has been found to have many side effects including nephrotoxicity and neurotoxicity. Despite this, some patients cannot avoid using CsA during pregnancy and this can be detrimental to both the patient and the foetus.
View Article and Find Full Text PDFShikonin is a naphthoquinone compound extracted from Chinese comfrey for treating cancer. However, there are few reports on its research on vertebrate tissue regeneration. Zebrafish is an ideal model for studying organ regeneration.
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