Rhizoma Alismatis Decoction improved mitochondrial dysfunction to alleviate SASP by enhancing autophagy flux and apoptosis in hyperlipidemia acute pancreatitis.

Background: Acute pancreatitis (AP) is an inflammatory disorder of the exocrine pancreas, especially hyperlipidemia acute pancreatitis (HLAP) is the third leading cause of acute pancreatitis which is more severe with a greater incidence of persistent multiorgan failure. HLAP inflicts injury upon the organelles within the acinar cell, particularly mitochondria, the endolysosomal-autophagy system, and is accompanied by senescence-associated secretory phenotype (SASP). RAD, only two consists of Rhizoma Alismatis and Atractylodes macrocephala Rhizoma, which is best known for its ability to anti-inflammatory and lipid-lowering.

Corydalis saxicola Bunting total alkaloids improve NAFLD by suppressing de novo lipogenesis through the AMPK-SREBP1 axis.

Ethnopharmacological Relevance: Along with the gradually increasing incidence, nonalcoholic fatty liver disease (NAFLD) has already been influencing the health of more and more people in the world. Corydalis saxicola Bunting (CSB), a valuable folk medicine, is the dried whole grass of a perennial herb, Yanhuanglian (Papaveraceae), which has significant effects on various hepatitis, liver fibrosis, cirrhosis and other liver diseases. Corydalis saxicola Bunting total alkaloids (CSBTA), a mixture of alkaloids extracted from CSB, exhibit widely-accepted hepatoprotective effects.

Fine Classification of UAV Urban Nighttime Light Images Based on Object-Oriented Approach.

Fine classification of urban nighttime lighting is a key prerequisite step for small-scale nighttime urban research. In order to fill the gap of high-resolution urban nighttime light image classification and recognition research, this paper is based on a small rotary-wing UAV platform, taking the nighttime static monocular tilted light images of communities near Meixi Lake in Changsha City as research data. Using an object-oriented classification method to fully extract the spectral, textural and geometric features of urban nighttime lights, we build four types of classification models based on random forest (RF), support vector machine (SVM), K-nearest neighbor (KNN) and decision tree (DT), respectively, to finely extract five types of nighttime lights: window light, neon light, road reflective light, building reflective light and background.

Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-κB pathways in mice.

Corydalis saxicola Bunting (Yanhuanglian), distributed in Southwest China, is mainly used for treatment of hepatitis, oral mucosal erosion, conjunctivitis, dysentery, acute abdominal pain and hemorrhoids in the folk. Corydalis saxicola Bunting Total Alkaloids (CSBTA) are the active ingredients extracted from the root of C. saxicola bunting.

Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats.

Metastatic bone pain is characterized by insufferable bone pain and abnormal bone structure. A major goal of bone cancer treatment is to ameliorate osteolytic lesion induced by tumor cells. Bunting total alkaloids (CSBTA), the alkaloid compounds extracted from the root of Bunting, have been shown to possess anticancer and analgesic properties In this study, we aimed to verify whether CSBTA could relieve cancer induced bone pain and inhibit osteoclastogenesis.

Influence of High-Temperature Oxidation and Test Conditions on the Dynamic Mechanical Properties of 2.5D SiC/SiC Composites.

The influence of microstructure evolution on the dynamic mechanical properties, including storage modulus and internal friction, of the 2.5D SiC/SiC composites after high-temperature treatment (800 °C and 1400 °C) in the air was investigated by three-point bending vibration test. The effects of test frequency and amplitude on storage modulus and internal friction were also evaluated.