Development and validation of a nomogram to predict long-term cancer-specific survival for patients with osteosarcoma.

The present work aimed to establish a new model to accurately estimate overall survival (OS) as well as cancer-specific survival (CSS) of osteosarcoma. Osteosarcoma cases were collected from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2017 and randomized as training or validation sets. Then, the OS- and CSS-related variables were discovered through multivariate Cox regression analysis to develop new nomograms to predict the 1-, 3- and 5-year OS and CSS.

SNHG10/miR-141-3p/WTAP axis promotes osteosarcoma proliferation and migration.

LncRNAs have been suggested to participate in the growth and metastasis of cancer through a variety of molecular mechanisms. Recently, SNHG10, a newly discovered lncRNA, is reported to play a role of an oncogene in osteosarcoma (OS) genesis. Nonetheless, the mechanism underlying OS remains unclear.

A Dual-Emission Nanohybrid of Gold Nanoclusters and Carbon Dots for Ratiometric Fluorescence Detection of Reactive Oxygen Species and Glucose.

Detecting reactive oxygen species (ROS) is critical for understanding the mechanisms of diseases. In this work, a convenient ratiometric fluorescent method for determination of ROS was developed basing on a nontoxic nanohybrid system which was constructed by carbon dots (CDs) and gold nanoclusters (Au NCs). The combination was prepared easily basing on self-assembly without any complex process, achieving maximum reservation of the two fluorescent properties.

Fast synthesis of fluorescent SiO@CdTe nanoparticles with reusability in detection of HO.

In this study, highly fluorescent core/shell SiO@CdTe nanoparticles (NPs) were synthesized conveniently and efficiently via a hydrothermal method. The as-prepared SiO@CdTe NPs were uniform with good fluorescence preservation. The SiO@CdTe NPs could be used for the rapid detection of HO with good sensitivity within several minutes.