Molecular glue degrader for tumor treatment.

Targeted Protein Degradation (TPD) represented by Proteolysis-Targeting Chimeras (PROTAC) is the frontier field in the research and development of antitumor therapy, in which oral drug HP518 Receives FDA Proceed Authorization for its IND Application for Prostate Cancer Treatment. Recently, molecular glue, functioning via degradation of the target protein is emerging as a promising modality for the development of therapeutic agents, while exhibits greater advantages over PROTAC, including improved efficiency, resistance-free properties, and the capacity to selectively target "undruggable" proteins. This marks a revolutionary advancement in the landscape of small molecule drugs.

Six-orders-of-magnitude-spanning dispersion measurement via Kalman filtering-aided white-light interferometry.

Dispersion plays a great role in ultrafast laser oscillators, ultrashort pulse amplifiers, and many other nonlinear optical dynamics. Therefore, dispersion measurement is crucial for device characterization, system design and nonlinear dynamics investigation therein. In this work, we demonstrate a versatile approach, i.

Time-resolved assessment of single-cell protein secretion by sequencing.

Secreted proteins play critical roles in cellular communication. Methods enabling concurrent measurement of cellular protein secretion, phenotypes and transcriptomes are still unavailable. Here we describe time-resolved assessment of protein secretion from single cells by sequencing (TRAPS-seq).

Plugging High-Permeability Zones of Oil Reservoirs by Microbially Mediated Calcium Carbonate Precipitation.

Simple plugging of the high-permeability "thief zones" of oil reservoirs is the most plausible and also the most straightforwardly achievable approach to enhance sweep efficiency and oil recovery. is a representative microorganism with the ability to precipitate calcium carbonate (CaCO) enzymatic hydrolysis of urea in the presence of calcium ions. Microbially induced calcium carbonate precipitation (MICP) can cement and seal the granular and fractured media and thus can be used as a potential microbial plugging agent for the high-permeability zones of oil reservoirs.

An integral terminal sliding mode control scheme for speed control system using a double-variable hydraulic transformer.

In recent years, with the aggravation of energy crisis and environmental pollution, the Common Pressure Rail (CPR) system with great energy saving potential has become a research hotspot in the hydraulic research area. However, as the key component of CPR system, hydraulic transformers have the problems of low efficiency and poor control effect, which limit its practical application. The main contribution of the paper is to propose a new type of double-variable hydraulic transformer (DVHT) and address the control issue.

Apolipoprotein ɛ4 is Associated with Dementia and Cognitive Impairment Predominantly Due to Alzheimer's Disease and Not with Vascular Cognitive Impairment: A Singapore-Based Cohort.

Background And Objective: While the association for apolipoprotein ɛ4 allele (APOE4) with Alzheimer's disease (AD) has been consistently confirmed, the association with vascular cognitive impairment (VCI) is unclear. We therefore explored the relationship of APOE with both AD and cerebrovascular disease (CeVD) by examining the prevalence of APOE4 in AD, AD with CeVD and vascular dementia (VaD), as well as in cognitive impairment no dementia (CIND) with and without CeVD.

Methods: We performed a case-control study with subjects recruited from memory clinics and the community.