Publications by authors named "Jiefeng Ren"
Article Synopsis
- The study aimed to develop a machine learning model to predict composite thromboembolic events (CTEs) in elderly patients with atrial fibrillation (AF) to improve clinical decision-making.
- A total of 6,079 hospitalized patients aged 75 and older were analyzed using various machine learning techniques, including random forest and logistic regression, to handle missing data and evaluate the model's performance.
- The random forest model emerged as the most effective, achieving high accuracy in predicting CTEs and identifying key features associated with these events through advanced analytical methods like LASSO and SHAP.
Background: Upper gastrointestinal bleeding (UGIB) in older patients is associated with substantial in-hospital morbidity and mortality. This study aimed to develop and validate a simplified risk score for predicting 30-day in-hospital mortality in this population.
Methods: A retrospective analysis was conducted on data from 1899 UGIB patients aged ≥ 65 years admitted to a single medical center between January 2010 and December 2019.
Thrombotic diseases have the characteristics of long latency period, rapid onset, and high mortality rate, which seriously threaten people's life and health. The aim of this research is to fabricate a novel indocyanine green complex of urokinase (ICG@uPA) and employ the amphiphilic PEG-PLGA polymer to deliver the complex as an enzyme-phototherapeutic synergistic thrombolysis platform. The noncovalent indocyanine green (ICG) complex of urokinase (ICG@uPA) was prepared supramolecular self-assembly and then encapsulated into cRGD decorated polymeric nanoparticles (cRGD-ICG-uPA NPs) by double-emulsion solvent evaporation method.
View Article and Find Full Text PDFThis study aimed to investigate the protective effect of Xinmailong injection on rats with myocardial infarction. Thirty-six rats were induced myocardial infarction by operation, and six underwent sham operation. The myocardial infarction rats were randomly divided into three groups, 12 in each, and administered intraperitoneal injection of Xinmailong 5 mg/(kg·d), sodium creatine phosphate 80 mg/(kg·d), or normal saline as control respectively for 14 days.
View Article and Find Full Text PDFTo identify the exact molecular markers related to coronary slow flow syndrome (CSFS) and its prognosis. Data from 54 patients with CSFS diagnosed by coronary angiography and 101 normal control patients were collected and analyzed. Logistic regression analysis confirmed that homocysteine (Hcy; odds ratio: 1.
View Article and Find Full Text PDFObjective: This study was aimed to assess whether sleep disorder was associated with an increased risk of less nocturnal blood pressure (BP) dipping in elderly patients with hypertension.
Methods: Cases were 1006 patients, aged >60 years, who were admitted to hospital with diagnosed hypertension during 2016-2017, and were divided into three groups with the systolic nocturnal BP dipping of 10%, and 0% as the cut-off value. The patients' sleep was evaluated by Pittsburgh sleep quality index (PSQI).