Qualitative analysis of concordance in advance care planning discussions between patients with advanced cancer and their surrogate decision makers.

Objectives: This study aimed to explore the concordance in advance care planning (ACP) discussions between patients with advanced cancer and surrogate decision makers within an oncology ward.

Design: Purposive and snowball sampling methods were used in this qualitative study, which involved conducting semistructured interviews to gather patients with advanced cancer and their surrogate decision makers. Interpretative phenomenological analysis was performed on the interview data to identify commonalities and differences in ACP discussions and to explore the factors influencing these differences.

How Do Parents With Advanced Cancer Communicate With Their Children? A Systematic Review and Meta-Synthesis of Qualitative Studies.

Objective: Many cancer patients are raising young children while suffering from the seriousness of the illness, and it is challenging for parents to talk to their children about their parents' advanced cancer. The purpose of this systematic review was to synthesize the existing evidence on parents' and children's experiences of communicating about parental advanced cancer.

Methods: Seven databases including Pubmed, Web of Science, Embase (OVID), PROQUEST health and medical, CINAL Complete (EMBSO), Medline (OVID), Cochrane Library were systematically searched.

Mediating Effect of Felt Obligation Between Inclusive Leadership and Caring Behavior of Chinese Nurses.

Purpose: It aims to validate the mediating role of felt obligation between inclusive leadership and the caring behavior of clinical nurses using a structural equation model.

Methods: All of the nurses were assessed with the general information questionnaire, caring behavior scale, felt obligation scale and inclusive leadership questionnaire. AMOS 21.

Level and Influencing Factors of Clinical Nurses' Caring Behaviour in Southern China.

A cross-sectional descriptive study was conducted to assess the level of caring behaviour among clinical nurses in Southern China and explore its influencing factors. The study was carried out in the Sixth Affiliated Hospital, South China University of Technology, Guangdong, China, from December 2022 to February 2023. A total of 537 nurses participated, and the mean scores for caring behaviour, responsibility perception, and inclusive leadership were examined.

Experience of multidisciplinary medical teams on humanistic palliative care in oncology wards: a descriptive qualitative study in Southern China.

Objectives: This study aimed to explore the experiences of multidisciplinary medical teams in implementing humanistic palliative care within the oncology ward.

Design: Purposive and snowball sampling methods were used in this qualitative study, which involved conducting semistructured interviews to gather personal experiences from members of multidisciplinary medical teams providing humanistic palliative care in the oncology ward.

Setting: The research was conducted in the oncology ward of a tertiary hospital located in Foshan, China.

The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation.

The Mulibrey (Muscle-liver-brain-eye) nanism caused by loss-of-function variants in TRIM37 gene is an autosomal recessive disorder characterized by severe growth failure and constrictive pericarditis. These patients also suffer from severe respiratory infections, co-incident with an increased mortality rate. Here, we revealed that TRIM37 variants were associated with recurrent infection.

Lactate anions participate in T cell cytokine production and function.

After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in T cells after TCR activation.