Antitumor activity of 7RH, a discoidin domain receptor 1 inhibitor, alone or in combination with dasatinib exhibits antitumor effects in nasopharyngeal carcinoma cells.

Dysregulation of the discoidin domain receptors (DDRs) has been implicated in the development of numerous types of tumors, including head and neck cancer, and nasopharyngeal, breast, ovarian and esophageal carcinomas. Furthermore, agents that inhibit DDR1 activity are hypothesized to be useful for the treatment of nasopharyngeal carcinoma (NPC). The aim of the present study was to evaluate the effect of the DDR1 inhibitory (3-(2-(pyrazolo(1,5-a)pyrimidin-6-yl)-ethynyl)benzamide compound, 7RH, in NPC cells both and , and its effect when used in combination with dasatinib, a SRC family kinase (SFK) inhibitor.

The vocal aerodynamic change in female patients with muscular tension dysphonia after voice training.

Objective: To investigate the changes of vocal aerodynamics indicators after voice training in female patients with muscular tension dysphonia (MTD).

Methods: Twenty-one female MTD patients (before voice training and 12 weeks after voice training) and 20 female volunteers with normal voices (the control group) received vocal aerodynamic analysis. Parameters included subglottal pressure (SGP), aerodynamic power (AP), mean expiratory airflow (MEA), and maximum phonation time (MPT) were recorded and analyzed by phonatory aerodynamic system.

[Mechanism of radiosensitization of 3-methyladenine in human hypopharynx cancer cells].

Objective: To investigate the radiosensitizing effect and its mechanism of 3-MA in human hypopharynx cancer cells.

Methods: 5 mmol/L of 3-MA combined with 2 Gy or 4 Gy of X-ray was utilized to deal with Fadu cells, and the cell livability (cloning efficiency) and DNA lesion severity (tail moment) of each groups was examined by clonogenic survival assay and comet assay, then differences were compared between groups by independent-sample T test. Fadu cells were then treated with different dose of 3-MA (1, 2, 5, 10 mmol/L), the alteration of cell cycle distribution was detected by flow cytometer, and differences among groups were analyzed through one-way analysis of variance.

[Application of narrow band imaging endoscopy in the diagnosis of nasopharyngeal lesions].

Objective: To evaluate the value of narrow band imaging (NBI) endoscopy in the diagnosis of nasopharyngeal lesions.

Methods: Between December 2009 and April 2010, a total of 124 patients with nasopharyngeal lesions were examined with electronic nasopharyngolaryngoscope equipped with the white light mode and NBI mode. The biopsies of nasopharyngeal lesions were done in all patients.

Inhibitor of differentiation 1 contributes to head and neck squamous cell carcinoma survival via the NF-kappaB/survivin and phosphoinositide 3-kinase/Akt signaling pathways.

Purpose: A key issue in cancer is apoptosis resistance. However, little is known about the transcription factors that contribute to cellular survival of head and neck squamous cell carcinoma (HNSCC).

Experimental Design: Three batches (54, 64, and 38) of HNSCC specimens were used for cellular and molecular analyses to determine the major molecular signaling pathways for cellular survival in HNSCC.

[Analysis of surgical treatment of nasopharyngeal angiofibroma].

Objective: To study the individual surgical treatment of nasopharyngeal angiofibroma.

Methods: Between Feb. 1989 and Oct.

[Repair of pharynx with acellular dermal matrix].

Objective: To evaluate the clinical use of acellular dermal matrix (ADM) in the repair of pharynx.

Method: From June 2003 to December 2004, 18 cases of laryngopharyngeal carcinoma or oropharyngeal carcinoma accepted treatment of surgery. Four of them had the tumor in the place of posterior wall of laryngopharynx or oropharynx.

[Endoscopic thyroid gland surgery without carbon dioxide neck insufflation].

Objective: To evaluate endoscopic thyroid gland surgery without carbon dioxide neck insufflation.

Methods: Sixteen patients with thyroid gland benign tumor, aged from 23-62 years, were selected and treated with endoscopic surgery. Eight cases received whole thyroid lobectomy and the other eight cases received partial thyroid lobectomy, the procedure was through a wall method or a single 2.

[Relationship between expression of survivin and prognosis in human laryngeal squamous cell carcinoma].

Background & Objective: A novel inhibitor of apoptosis Survivin has recently been found in many common human cancers but not in normal tissues. Its potential distribution in human laryngeal squamous cell carcinoma (HLSCC) and its implication for inhibition of apoptosis were not yet very clear. This study was designed to investigate the expression of survivin and the probabilities of using it as a new indicator of the prognosis of HLSCC.