[Experimental study of repairing segmental bone defect with reconstituted freeze-dried bone allograft].

Objective: To study the effect of basic fibroblast growth factor (bFGF) and hyaluronic acid gel (HAG) combined with freeze-dried bone allograft in repairing segmental bone defect and to explore their mechanism.

Methods: The 15 mm segmental bone/periosteum defects were created on bilateral radius in 50 New Zealand rabbits and were treated with four different kinds of implants on 25 radius respectively (group A: bFGF and HAG combined with freeze-dried bone; group B: bFGF combined with freeze-dried bone; group C: HAG combined with freeze-dried bone; group D: simple freeze-dried bone as a control). The repair of defect was observed radiologically and histologically and were analyzed by radionuclide bone imaging and measurement of calcium contents at different periods.

[Experimental study on stimulation of guided bone regeneration by autogenous bone marrow].

Objective: To study the effect of autogenous bone marrow on guided bone regeneration (GBR), and evaluate the repairing ability of GBR in bone defect with autogenous bone marrow.

Methods: Ten mm segmental defects were produced in both radii of 18 rabbits. The defect was bridged with a silicon tube.