Publications by authors named "Jie-Zhi Ma"
Triclocarban (TCC) and triclosan (TCS) have been detected ubiquitously in human body and evoked increasing concerns. This study aimed to reveal the induction risks of TCC and TCS on triple negative breast cancer through non-genomic GPER-mediated signaling pathways. Molecular simulation indicated that TCC exhibited higher GPER binding affinity than TCS theoretically.
View Article and Find Full Text PDFArticle Synopsis
- - Neonicotinoid insecticides (NIs) are prevalent in the environment and human bodies, showing concentrations that could potentially affect health, but their mechanisms regarding toxicity, especially in relation to breast cancer, remain unclear.
- - Research focused on the G protein-coupled estrogen receptor (GPER) found that certain NIs, particularly acetamiprid (ACE), significantly activated GPER, leading to increased migration and proliferation of breast cancer cells.
- - ACE was shown to promote breast cancer growth and lung metastasis in mouse models via the GPER mechanism, suggesting that NIs could potentially exacerbate breast cancer progression at levels encountered in human exposure.
Niclosamide (NIC), a helminthic drug used widely for controlling schistosomiasis, can reportedly disrupt the endocrine system. However, its underlying mechanisms are still unclear. In this study, we revealed the potential endocrine disruption mechanism of NIC by activating estrogen receptors (ERs) and estrogen-related receptors (ERRs).
View Article and Find Full Text PDF