Spatial structure of rodent populations and infection patterns of hantavirus in seven villages of Shandong Province from February 2006 to January 2007.

Background: Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimating the spatial distribution of rodent populations and their hantavirus infection patterns, to describe the spatial relationships of hantavirus strains in small ecological areas and to identify key areas in endemic areas of HFRS for future public health planning and resource allocation.

Methods: Rodent sampling was conducted in seven villages in Junan county from February 2006 to January 2007 using field epidemiological surveillance.

[Study on the incidence and spatiotemporal dynamic variation of hemorrhagic fever with renal syndrome in Shandong province].

Objective: To study the incidence and spatiotemporal dynamic variation of hemorrhagic fever with renal syndrome (HFRS) in Shandong province.

Methods: According to surveillance data on HFRS epidemics and host animals, a 'contour area multifractal model' was estimated on the HFRS' incidence and multi-analysis model was applied to study spatiotemporal dynamic variation.

Results: The process could be classified into 5 periods: 1st period (1974-1981) when HFRS was in completely natural focal state in Shandong, and the nature of focus was typical Apodemus type.

[Meta analysis for relationship between exposure of free silicon dioxide and lung tumor].

Objective: Meta-analysis is applied to process a systematic, comprehensive evaluation on the relationship between silica exposure and lung cancer in order to provide scientific evidences for controlling measures and offer a case for EBOM.

Methods: According to established entrance standards, the collected original articles on silica exposure and lung cancer were classified and put in order, then fixed effects model and random effects model were used which suited to analyze occupational epidemiology and occupational tumor materials, and their correlation intensity were analyzed. First, combined SMR and 95% CI values for case-control study and cohort study were calculated respectively.

[The "horse-shoe effect"of correspondence analysis for human population genetic structure and its population genetic explanation].

At present study, the reasons of "horse-shoe effect" in correspondence analysis for analyzing human population genetic structure was explained. Based on the structure of gene frequency matrix, we displaye the different patterns of Scallergram of correspondent analysis from different types of loci (HLA-A locus, and STR- CSF1PO locus in Chinese Han populations). The results indicate that different types of loci showed different patterns of Scallergram of correspondent analysis.

Spatial genetic structure of two HIV-I-resistant polymorphisms (CCR2-64 I and SDF1-3'A) alleles in population of Shandong Province, China.

Objective: To explore the spatial genetic structure of two HIV-I-resistant polymorphisms (CCR2-64 I and SDF1-3'A) alleles in the population of Shandong Province, China.

Methods: Using the techniques of spatial stratified sampling and spatial statistics, the spatial genetic structure of the locus (CCR2-64 I and SDF1-3'A), which was shown to be important co-receptor for HIV infection, was quantified from the populations of 36 sampled counties of Shandong Province, and a total of 3147 and 3172 samples were taken for testing CCR2-64I and SDF1-3'A respectively from individuals without known history of HIV-I infection and AIDS symptoms.

Results: There were significantly spatial genetic structures of the two alleles at different spatial distance classes on the scale of populations, but on the scale of individuals, no spatial structure was found in either the whole area of Shandong Province or the area of each sampled county.

[Meta-analysis on the relationship of chlamydia pneumonia infection and coronary heart disease].

Objective: To determine the relationship of chlamydia pneumonia (CP) infection and coronary heart disease (CHD).

Methods: Studies published before 2004 that had reported on correlations between CHD and CP were collected. Studies were sorted into four sorts according to different testing methods.

[The use of Meta-analysis in the evaluation on diagnostic tests].

Objective: To introduce Meta-analysis in evaluating diagnostic tests.

Method: Adjusted SROC method was used in assessing 7 diagnostic tests on fatty liver.

Results: The pooled sensitivity and specificity of type B ultrasonography were 0.

The "Kriging" model of spatial genetic structure in human population genetics.

This paper presents the application of Kriging technique in the field of human population genetics for quantifying the spatial genetic heterogeneity of HLA-A locus in the area of China,and for mapping its spatial genetic structure using the measurement of synthetic genetic structure (SPC) and the principal components (PC). Both principles of the method and the basic equations are given. The Kriging model has several advantages over other interpolation and smoothing methods.

[Imaging diagnosis for fatty liver: a systematic review].

Objective: To systematically assess imaging diagnostic tests for fatty liver and provide a decision-making basis for clinical diagnosis and screening.

Methods: Electronic searches were conducted on the Chinese Biomedical Database, PubMed, and EMBASE, combining with manually searching of Chinese literature. All searches were completed until November 2002.

[Multiple nonlinear statistical method of population genetic structure based on the allelic polymorphism data].

The distribution and structure of the allelic polymorphism data are analyzed and it is pointed out that the distribution of allelic polymorphism data reveals the characteristic of closed data (also named as compositional data or data of constant sum). It is interpreted that the correlation structure of the allelic polymorphism data contains null correlations introduced by "closure" and the statistical distribution of the data is not normal because of its constant row sum, which resulted in great difficulties in analyzing the data with traditional multiple linear statistical methods such as principal component analysis, factor analysis, cluster analysis and canonical correlation analysis. Based on the theory of compositional data analysis proposed by Aitchison in 1982, a multiple nonlinear statistical method originating from the "logratios" approach to the statistical analysis of compositional data is put forward in this paper.

[Alpha-blockers and bioflavonoids in men with chronic nonbacterial prostatitis (NIH-IIIa): a prospective, placebo-controlled trial].

Objective: The National Institutes of Health (NIH) category IIIa chronic prostatitis syndromes (non bacterial chronic prostatitis) were common disorders but with few effective therapies. Alpha-blockers and bioflavonoids had recently been reported in randomized controlled trials to improve the symptom of these disorders in a significant proportion of men. The aim of this study was to confirm these findings in a prospective randomized, placebo-controlled trial.

[Study of X-irradiation to enhance the functional and structural recovery of the injured spinal cord of rat].

Objective: To explore whether X-irradiation can enhance the functional and structural recovery of the injured spinal cord of rats.

Methods: Seventy Sprague-Dawley rats received spinal cord injury by clip compression at the T2 level were randomly divided into two groups. The experimental group received X-irradiation at 14 days after injury, the control group did not receive X-irradiation.

[Meta-analysis of assisted music therapy for chronic schizophrenia].

Objective: To evaluate the effect of assisted music therapy for chronic schizophrenia.

Methods: 11 articles including 603 chronic schizophrenia patients were meta-analyzed using fixed effect model or random effect model.

Results: 6 randomized controlled trials were synthesized, showing that the difference was significant in statistics between experimental group (patients with music and drugs therapy) and control group (patients with drugs therapy only).

[Meta-analysis of the relationship between smoking and stomach cancer].

Objective: To explore the risk of stomach cancer associated with cigarette smoking.

Methods: Meta-analysis was used to make formal summary statements about the relationship between smoking and stomach cancer. The results of the studies were analyzed by studied type(case-control study and cohort study) and gender(male and female).

[The study of biological properties of gliomas].

In order to explore the new methods of biological treatment of human gliomas, this project is to study the biological properties of gliomas from four different aspects, the results show that there is a IL-6 autocrine loop in human gliomas and the growth of gliomas will be inhibited when the autocrine loop is broken. There is a magnificent predominant expression of Th2 cytokines in human gliomas and human glioma cells, the switching of Th2 to Th1 can inhibit the proliferation of glioma cells. The dosage of 100 micrograms/ml of erythromycin is the best of therapeutic effect.

[The application of Weibull parameter model to survival analysis of glioma].

Objective: To investigate the factors affecting the survival and to predict the survival time of glioma.

Methods: Graph method was applied to fit the type of probability distribution of patients' postoperative survival time. As one suitable model, Weibull regression model tested by residual analysis was used to identify prognostic factors for postoperative survival and to predict patients' post-operative survival time.