Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study.

Background: Delayed diagnosis of inflammatory bowel disease (IBD) is common in Europe and North America, with limited research in Asia. We aimed to investigate factors influencing delayed diagnosis of IBD in Chinese children and the impact of delayed diagnosis on growth.

Methods: This was a retrospective study.

[Clinical characteristics of 267 children with eosinophilic gastrointestinal disease: a multicenter study].

Objectives: To explore the clinical manifestations, endoscopic findings, histopathological changes, treatment, and prognosis of eosinophilic gastrointestinal disease (EGID) in children, with the aim of enhancing awareness among pediatricians about this condition.

Methods: Data of 267 children with EGID were prospectively collected from January 2019 to July 2022 at Jiangxi Children's Hospital, Hunan Children's Hospital, and Henan Children's Hospital. The age of onset, symptoms, physical signs, laboratory examination results, endoscopic findings, histopathological changes, and treatment outcomes were observed.

[Mechanism of action and exogenous supplementation of vitamin D in Crohn's disease].

Vitamin D can not only regulate calcium and phosphorus metabolism, but also exert an immunoregulatory effect. Vitamin D deficiency is common in patients with Crohn's disease (CD). Studies have shown that vitamin D is associated with CD and other autoimmune diseases and can improve the condition of patients with CD and promote their recovery by regulating intestinal immunity, repairing the intestinal mucosal barrier, inhibiting intestinal fibrosis, enhancing the response to infliximab, and regulating intestinal microbiota.

[Nutritional status and its influencing factors in children with newly diagnosed inflammatory bowel disease].

Objectives: To investigate the nutritional status and its influencing factors in children with newly diagnosed inflammatory bowel disease (IBD).

Methods: A retrospective analysis was conducted on the clinical data of children who were diagnosed with IBD for the first time in Hunan Children's Hospital from January 2015 to December 2021. Diagnostic delay was defined as the time from the symptom onset to IBD diagnosis being in the upper quartile (-) of all IBD children in the study.

[Clinical features of intestinal polyps and risk factors for secondary intussusception in children: an analysis of 2 669 cases].

Objectives: To study the clinical features of intestinal polyps and the risk factors for secondary intussusception in children.

Methods: A retrospective analysis was performed for the medical data of 2 669 children with intestinal polyps. According to the presence or absence of secondary intussusception, they were divided into two groups: intussusception (=346) and non-intussusception (=2 323).

[ infection and its susceptibility factors in children with inflammatory bowel disease].

Objective: To investigate the incidence rates of colonization and infection (CDI) in children with inflammatory bowel disease (IBD) and the susceptibility factors for CDI in children with IBD.

Methods: A total of 62 children diagnosed with IBD were enrolled as the IBD group. Forty-two children who attended the hospital due to persistent or chronic diarrhea and were excluded from IBD were enrolled as the non-IBD group.

Temporal and vertical variations of polycyclic aromatic hydrocarbon at low elevations in an industrial city of southern Taiwan.

Considered that human activities mostly occur below building heights, the objective of this study was to investigate the temporal variations of fine particular matter (PM)-associated polycyclic aromatic hydrocarbons (PAHs) and benzo[a]pyrene-equivalent (BaP) concentrations at four different elevations (6.1, 12.4, 18.

Clinicopathological characteristics and treatment outcome in obese patients with diffuse large B-cell lymphoma.

Background: Aberrant MYC and BCL2 expression, cell of origin (COO), and National Comprehensive Cancer Network international prognostic index (NCCN-IPI) are commonly used for risk assessment and treatment decision in patients with diffuse large B-cell lymphoma (DLBCL). Although obesity has been shown to be of predictive value in DLBCL patients, it remains unclear whether it retains its prognostic relevance after those aforementioned novel factors being taken into consideration.

Methods: Patients with DLBCL were identified retrospectively in a single institute and data were collected through electronic databases and pharmacy records.

[Construction of rat interleukin-10 adenoviral vector and its expression in bone marrow mesenchymal stem cells].

Objective: To construct the recombinant adenoviral vector carrying the rat interleukin-10 (rIL-10) gene, and to investigate whether it is stably expressed in bone marrow mesenchymal stem cells.

Methods: The rIL-10 gene was amplified by PCR from template rIL-10 cDNA, and the recovered 656 bp rIL-10 DNA fragment was cloned into pcDNA3.1 to construct pcDNA3.

[Effect of glutamine-supplemented enteral nutrition on the apoptosis of colonic mucosal cells in young rats with inflammatory bowl disease].

Objective: To study the effect of glutamine-supplemented enteral nutrition in regulating the apoptosis of intestinal mucosal cells and promoting mucosal healing in young rats with inflammatory bowl disease (IBD).

Methods: A total of 80 male Sprague-Dawley rats aged 4-5 weeks were randomly divided into 4 groups: blank control, IBD model, short peptide, and short peptide+glutamine (n=20 each). The IBD model was prepared by a single colon perfusion of 3-nitrobenzene sulfonic acid.

Clinical and Genetic Study of Children With Peutz-Jeghers Syndrome Identifies a High Frequency of STK11 De Novo Mutation.

Objectives: The present study aims to identify the genotype-phenotype correlation in children with Peutz-Jeghers Syndrome (PJS) through the analysis of STK11 gene mutations in the context of clinical and pathological characteristics.

Method: In this observational cohort study, the clinical characteristics of 18 families diagnosed with pediatric PJS were collected. Genomic DNA from the peripheral blood of affected children and their family members was collected.

[Features and management of very early onset inflammatory bowel disease].

Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease of unknown etiology. This disease includes three main types: Crohn′s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U). IBD is frequently presented in adults, but in recent years, there is a rising incidence in pediatric populations.

Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in -mutated myeloproliferative neoplasms.

High mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is negatively regulated by microRNA through binding to it's 3'-untranslated region. Transgenic mice expressing with a truncation of its 3'-untranslated region has been shown to exhibit a myeloproliferative phenotype. To decipher the axis in myeloproliferative neoplasms, we employed an model supplemented with clinical correlation.

Prognostic factors of primary resected retroperitoneal soft tissue sarcoma: Analysis from a single asian tertiary center and external validation of gronchi's nomogram.

Background: Surgery is the potentially curative treatment for retroperitoneal sarcoma (RS), but complete resectability is frequently a challenge. This study aimed to characterize the clinical features, prognostic factors and treatment outcomes.

Methods: A cohort of 144 patients with RS was surveyed retrospectively from January 1st, 2000 to July 30th, 2011.

[Clinical characteristics of infants with allergic proctocolitis: a retrospective study of 96 cases].

Objective: To study the clinical characteristics of hospitalized infants with allergic proctocolitis, and to provide a scientific basis for early diagnosis and effective treatment of allergic proctocolitis.

Methods: The clinical data of 96 infants with allergic proctocolitis between September 2011 and March 2013 were reviewed retrospectively. Descriptive analysis was performed to assess the clinical characteristics of allergic proctocolitis.

[Clinical analysis of 10 cases of pediatric Crohn's disease].

Objective: To study the clinical features and treatment of pediatric Crohn's disease (CD).

Methods: Clinical data of 10 children with active CD diagnosed between 2005 and 2013 were retrospectively reviewed.

Results: Abdominal pain, diarrhea, and bloody stools were the most common symptoms in these patients, usually accompanied by different degrees of growth retardation and nutritional disorders.

Frequencies, clinical characteristics, and outcome of somatic CALR mutations in JAK2-unmutated essential thrombocythemia.

Calreticulin (CALR) mutations were recently identified in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF) devoid of JAK2 and MPL mutations. We evaluated the clinical, laboratory, and molecular features of a Taiwanese population of patients with ET. Among 147 ET patients, CALR mutations were detected in 33 (22.

[Clinical effect of triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori infection in children].

Objective: To evaluate the clinical effect of proton pump inhibitor-based triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori (Hp) infection among children in terms of Hp eradication rate and incidence of adverse events.

Methods: A prospective randomised controlled study was conducted on 240 children with a confirmed diagnosis of Hp infection. These patients were randomized into triple therapy (n=120) and probiotics groups (n=120).

[Clinical application of single-balloon enteroscopy in children with small intestinal bleeding].

Objective: To investigate the diagnostic value and safety of single-balloon electronic enteroscopy in children with small intestinal bleeding.

Methods: Seventy children with clinically suspected small intestinal bleeding, including 38 males and 32 females aged 4-13 years, underwent single-balloon enteroscopy under general anesthesia. Twenty-six cases underwent the procedure through the mouth, 32 cases through the anus, and 12 cases through both.

[Research progress in causes of persistent or chronic diarrhea in children].

The disease course of children with persistent or chronic diarrhea lasts from two weeks to two months or over. Diarrhea is a clinical syndrome caused by a group of multiple etiologies. This paper reviews common causes of persistent or chronic diarrhea in children, including intestinal infections, nonspecific inflammatory bowel diseases, food allergy, lactose intolerance, antibiotic-associated diarrhea, neural regulation abnormality, immunodeficiency disease, malnutrition, Celiac disease and zinc deficiency.

[Clinical characteristics of children with acute pancreatitis].

Objective: To analyze the characteristics of children with acute pancreatitis and provide the basis of early diagnosis and treatment.

Methods: Totally 121 children with acute pancreatitis admitted to Hunan Children's Hospital between March 2003 and December 2009 were enrolled in this retrospective study. The data of clinical manifestations, biochemical examinations, imaging and prognosis were summarized and statistically analyzed.