Publications by authors named "Jie-Yu Lu"
Cell Death Discov
March 2024
Article Synopsis
- NAP1L1 plays a critical role in the abnormal growth of hepatocellular carcinoma (HCC) cells by influencing apoptosis but has limited effects on cell migration and invasion.
- Knockdown of NAP1L1 reduces BIRC2 protein levels through post-translational mechanisms, suggesting it helps regulate BIRC2 stability rather than its transcription.
- The study identifies UBR4 as a key molecule that connects NAP1L1 and BIRC2, showing that targeting NAP1L1 could be a potential therapeutic strategy to slow down HCC progression in patients with elevated NAP1L1 or BIRC2 levels.
