Multiple Copies of Mobile Tigecycline Resistance Efflux Pump Gene Cluster Identified in Chromosome of spp.

The appearance and prevalence of novel plasmid-encoded tigecycline resistance efflux pump gene clusters and in have raised a threat to public health. Here, another tigecycline resistance gene cluster, , was identified in two isolates recovered from fish meat and vegetables. Cloning confirmed the expression of mediated the resistance to tigecycline and decreased susceptibility to tetracyclines and cephalosporins in both Escherichia coli and .