Publications by authors named "Jie-Ru Shih"
Chinese hamster ovary (CHO) cells are the predominant cell chassis for biopharmaceutical production. Engineering cellular pathways related to cell death, metabolism, and glycosylation in CHO cells is desired but challenging. Here, we present a novel approach that exploits CRISPR-Cas13d for gene silencing and CHO cell engineering.
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- * A study using a yeast two-hybrid screen identified six cellular proteins that can interact with the PA protein of the virus, with a focus on one called HAX1, known for its antiapoptotic properties.
- * HAX1 interacts with PA and influences its nuclear transport; when HAX1 is knocked down, it enhances virus replication and polymerase activity, highlighting HAX1's role as a host factor that restricts influenza A virus infection.