Publications by authors named "Jie-Liang Yang"
Due to the similar collagen composition and closely physiological relationship with soft connective tissues, demineralized bone matrices (DBMs) were used to repair the injured tendon or ligament. However, the osteoinductivity of DBMs would be a huge barrier of these applications. Hydrogen peroxide (H O ) has been proved to reduce the osteoinductivity of DBMs.
View Article and Find Full Text PDFDemineralized bone matrix (DBM), as an extracellular matrix (ECM), has had limited use as a medical replacement although studies have reported a possibility for its use in tendon or ligament tissue engineering. To be an acid-extracted organic matrix, DBM contains much of bone protein, with a small amount of inorganic solids and some cell debris. However, cell debris is a critical factor that triggers inflammatory reaction in clinical reconstructions using ECM.
View Article and Find Full Text PDFArticle Synopsis
- A new decellularization protocol was developed for processing bovine Achilles tendons to create a decellularized bovine tendon sheet (DBTS) scaffold aimed at tendon reconstruction.
- The effectiveness of decellularization was confirmed through DNA analysis and histological qualification, showing no significant changes to the essential properties of the native tendon extracellular matrix (ECM).
- The DBTS scaffold proved to be non-toxic and promoted fibroblast growth in vitro, demonstrating excellent compatibility when implanted in rat tissue, highlighting its potential for tendon reconstruction applications.
Article Synopsis
- The study looked at how the environment around stem cells, like the materials they grow on, is important for their growth and ability to become specialized cells.
- Researchers used special slices from tendons that had been cleaned of their cells to see if they could help stem cells grow and change into tendon cells.
- They found that these tendon slices helped the stem cells grow well and turn into tendon cells, suggesting this method could be useful for repairing or rebuilding tendons.