Copper-Catalyzed Aminosulfonylation of -Homoallyl Benzimidates with Sodium Sulfinates to Access Sulfonylated 1,3-Oxazines.

A facile copper-catalyzed aminosulfonylation of homoallyl benzimidates with sodium sulfinates in the presence of -butyl peroxybenzoate (TBPB) and XPhos ligand has been developed. By using this protocol, a variety of potentially bioactive 1,3-oxazines were directly synthesized. This method has the merits of a cheap catalyst, easily available and stable sulfone reagents, and simple operation.