Publications by authors named "Jie-Hua Jin"
Article Synopsis
- Recent research indicates that CD8+ T cells are crucial in controlling HIV-1 reservoirs in individuals on antiretroviral therapy, although their exact mechanisms are still unclear.
- In a study of 60 virologically suppressed HIV-1 patients, certain CD8+ T cell subsets were found to correlate with levels of HIV-1 DNA and RNA, revealing that specific central and terminally differentiated memory cells behaved differently in their responses.
- The findings suggest that CCL5-secreting CD8+ T cells may play a key role in limiting HIV-1 reservoirs, paving the way for new CD8+ T cell-based treatments aimed at curing HIV-1 infection.
Immune deficiency is one of the hallmarks of HIV infection and a major cause of adverse outcomes in people living with HIV (PLWH). Long-lived memory CD8 T cells (LLMCs) are essential executors of long-term protective immunity; however, the generation and maintenance of LLMCs during chronic HIV infection are not well understood. In the present study, we analyzed circulating LLMCs in healthy controls (HCs) and PLWH with different disease statuses, including treatment naïve patients (TNs), complete responders (CRs), and immunological nonresponders (INRs).
View Article and Find Full Text PDFThe viral reservoir is the major hurdle in developing and establishing an HIV cure. Understanding factors affecting the size and decay of this reservoir is crucial for the development of therapeutic strategies. Recent work highlighted that CD8+ T cells are involved in the control of viral replication in ART-treated HIV-1-infected individuals, but how CD8+ T cells sense and restrict the HIV reservoir are not fully understood.
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