Multicomponent Self-Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity.

The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH ) ) O] {[CeW O ] [TeW O ][CeSn(CH ) ] [TeW O ] } } (1 a) features dimensions of ca.

Risks and predicting factors of bleeding complications in hepatitis B virus-related acute-on-chronic liver failure.

Background/aims: This study aimed to provide supporting evidence for prevention and prognostic evaluation of bleeding complications in the early stage by exploring the risk and predicting factors in patients with acute-on-chronic liver failure (ACLF).

Materials And Methods: A total of 101 hospitalized patients with ACLF were retrospectively included from January 1, 2014 to December 31, 2015. The patients were divided into bleeding (n=38) and nonbleeding groups (n=63).

[Atmospheric Nitrogen Dioxide, Nitric Acid, Nitrate Nitrogen Concentrations, and Wet and Dry Deposition Rates in a Double Rice Region in Subtropical China].

Nitrogen dioxide (NO) and nitric acid (HNO) are nitrogen-containing acidic gases in the atmosphere, and they are important precursors of nitrate in aerosol and rainwater. The emission intensity of atmospheric nitrogen oxides is high in the subtropical region of China, but the concentrations and deposition rates of atmospheric nitrogen dioxide, nitric acid, particulate nitrate-nitrogen (NO-N), and rainwater nitrate-nitrogen (NO-N) in a double rice region in subtropical China are still unclear,. In this study, the atmosphere concentrations of NO-N, HNO-N, NO-N in PM, and NO-N and related meteorological parameters were simultaneously monitored in a typical double rice region within a subtropical hilly region of China, with the aim of determining the characteristics and influencing factors of NO-N, HNO-N, NO-N, and NO-N concentrations and quantifying the wet and dry deposition rates.

[Comparison Between Atmospheric Wet-only and Bulk Nitrogen Depositions at Two Sites in Subtropical China].

Atmospheric emissions of reactive nitrogen (N) species are at high levels and have caused high N deposition in China in recent years. In this study, atmospheric wet-only and bulk N depositions were monitored simultaneously in a two-year study at an agricultural site (HN) and a forest site (XS) in the Jinjing River catchment in Changsha County, Hunan Province in subtropical China. The differences in concentration and deposition of NH-N, NO-N, DON, and TN between wet-only and bulk N depositions were compared, and the correlation between wet-only and bulk N depositions was analyzed, with the aim of estimating atmospheric wet N deposition based on bulk N deposition.

[Atmospheric Ammonia/Ammonium-nitrogen Concentrations and Wet and Dry Deposition Rates in a Double Rice Region in Subtropical China].

Ammonia (NH) is the most abundant alkaline gas in the ambient air, and it is also one of the important precursors for the ammonium salts in aerosol and rainwater. Though the emission intensities of NH and acidic gases are high, the concentrations and deposition rates of atmospheric ammonia-nitrogen (NH-N), particulate ammonium-nitrogen (NH-N) and rainwater ammonium-nitrogen (NH-N) in double rice regions in subtropical China are still less known. In this study, atmospheric concentrations of NH-N, NH-N in PM and NH-N and related meteorological parameters were observed simultaneously in a typical double rice region in the subtropical hilly region of China, with the aim to clarify the characteristics and influencing factors of atmospheric NH/NH-N concentrations and to quantify the wet and dry deposition rates of atmospheric NH/NH-N.

Utility and safety of tolvaptan in cirrhotic patients with hyponatremia: A prospective cohort study.

Unlabelled: Introduction and aim. Hyponatremia is common in patients with decompensated cirrhosis and is associated with increased mortality. Tolvaptan, a vasopressor V2 receptor antagonist, can increase free water excretion, but its efficacy and safety in cirrhotic patients remain unclear.

[Relationship between hepatitis B virus polymerase gene mutation patterns of rtM204I/V and pre-core/basal core promoter mutations].

Objective: To investigate the relationship between mutations of rtM204V/I (methionine to valine or isoleucine at position rt204 of reverse transcriptase domain) in the hepatitis B virus (HBV) polymerase gene and the G1896A and G1899A single mutations in the pre-eore (PC) region and the A1762T and G1764A double-mutations in the basal core promoter (BCP) region.

Methods: A total of 2,849 hepatitis B complete genome sequences were retrieved from the GenBank/EMBL/DDBJ. The amino acid sequence of the of reverse transcriptase domain and genome sequences of the PC region and the BCP region were aligned using MEGA4 software.

Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma.

Purpose: More than 60% of patients with hepatocellular carcinoma (HCC) do not receive curative therapy as a result of late clinical presentation and diagnosis. We aimed to identify plasma microRNAs for diagnosing hepatitis B virus (HBV) -related HCC.

Patients And Methods: Plasma microRNA expression was investigated with three independent cohorts including 934 participants (healthy, chronic hepatitis B, cirrhosis, and HBV-related HCC), recruited between August 2008 and June 2010.

Expression of human glucocorticoid receptor in T lymphocytes in acute-on-chronic hepatitis B liver failure.

Background: Glucocorticoid receptor (GR) participates in the pathogenesis of liver inflammation. However, the potential role of GR in acute-on-chronic hepatitis B liver failure (ACHBLF) is still obscure.

Aim: This present study was aimed to determine peripheral GR expression in ACHBLF patients.

[Decreased expression of serum cortisol in patients with severe hepatitis].

Objective: To investigate the profile of serum cortisol levels in patients with severe hepatitis.

Methods: Fifty patients with viral hepatitis (including 30 severe hepatitis patients and 20 chronic hepatitis B patients) were enrolled in this present study. Serum cortisol concentration was tested using radioimmunoassay.

[Expression of nuclear factor-κB and its regulated cytokines in dendritic cells in patients with chronic severe hepatitis B and its clinical significance].

Objective: To investigate the correlation of nuclear factor-κB (NF-κB) level and its regulated cytokines in monocyte-derived dendritic cells (MoDC) with illness severity and prognosis in patients with chronic severe hepatitis B (CSHB).

Methods: Peripheral blood mononuclear cells (PBMC) were isolated by Ficoll density gradient separation from 37 patients with CSHB, 20 chronically HBV-infected patients, and 20 normal controls. Monocytes were acquired using immunomagnetic anti-CD14-beads.

Plasma alpha-tocopherol is negatively correlated with hepatocyte apoptosis in chronic hepatitis B patients.

Aim: Hepatocyte apoptosis is involved in the pathogenesis of liver diseases, while at the same time oxidative stress plays an important role in liver cell damage. This prompted us to evaluate the possible relationship between hepatocyte apoptosis and oxidative stress in patients with chronic hepatitis B.

Methods: CHB patients were placed in groups A (ALT >40 IU/L) and B (ALT View Article and Find Full Text PDF

[Hepatocyte apoptosis in the patients with chronic hepatitis B].

Objective: To investigate the relationship between hepatocyte apoptosis and the level of inducible nitric oxide synthase (iNOS) in hepatic tissue in the patients with chronic hepatitis B(Ct-IB).

Methods: We observed 37 cases with CHB and 10 normal controls. Transferase-mediated-UTP-biotin nick-end labling (TUNEL) technique was used to detect apoptosis cells and immunohistochemical staining were also performed to investigate the expression of inducible nitric oxide synthase (iNOS) in biopsy samples.

Hospital-acquired invasive pulmonary aspergillosis in patients with hepatic failure.

Background: Invasive pulmonary aspergillosis (IPA) is a rapid, progressive, fatal disease that occurs mostly in immunocompromised patients. Patients with severe liver disease are at a heightened risk for infections. Little is known about the clinical presentation including predisposing factors and treatment of IPA in patients with hepatic failure.