Surgical Navigation System for Hypertensive Intracerebral Hemorrhage Based on Mixed Reality.

Hypertensive intracerebral hemorrhage (HICH) is an intracerebral bleeding disease that affects 2.5 per 10,000 people worldwide each year. An effective way to cure this disease is puncture through the dura with a brain puncture drill and tube; the accuracy of the insertion determines the quality of the surgery.

Augmented reality surgical navigation system based on the spatial drift compensation method for glioma resection surgery.

Background: The number of patients who suffer from glioma has been increasing, and this malignancy is a serious threat to human health. The mainstream treatment for glioma is surgical resection; therefore, accurate resection can improve postoperative patient recovery.

Purpose: Many studies have investigated surgical navigation guided by mixed reality, with good outcomes.

Supramolecular Assembly of Shape Memory and Actuating Hydrogels for Programmable Shape Transformation.

The deformable diversity of organisms in nature has inspired the development of bionic hydrogel actuators. However, the anisotropic structures of hydrogel actuators cannot be altered after the fabrication process, which restricts hydrogel actuators to provide complex and diverse shape deformations. Herein, we propose a dual programming method to generate numerous anisotropic structures from initial isotropic gelatin-containing hydrogels; the isotropic hydrogel blocks could be first assembled into anisotropic structures based on the coil-triple helix transition of gelatin, and then, the assembled hydrogels could further be fixed into various temporary anisotropies, so that they can produce complex and diverse deformations under the stimulation of pH.

A neuroendoscopic navigation system based on dual-mode augmented reality for minimally invasive surgical treatment of hypertensive intracerebral hemorrhage.

Background And Objective: Hypertensive intracerebral hemorrhage is characterized by a high rate of morbidity, mortality, disability and recurrence. Neuroendoscopy has been utilized for treatment as an advanced technology. However, traditional neuroendoscopy allows professionals to see only tissue surfaces, and the field of vision is limited, which cannot provide spatial guidance.

Expression and Tumor-Promoting Effect of Tyrosine Phosphatase Receptor Type N (PTPRN) in Human Glioma.

Tyrosine phosphatase receptor type N (PTPRN) plays an important role in the regulation of the secretion pathways of various neuroendocrine cells. Moreover, PTPRN was demonstrated to play a crucial role in the initiation and progression of the signalling cascade regulating cell function. In this study, fifty-seven glioma patients were enrolled for clinical and prognostic analyses.

Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.

Purpose: The recent emergence of radioligand therapies for cancer treatment has increased enthusiasm for developing new theranostic strategies coupling both imaging and cytotoxicity in the same entity. In this study, we evaluated whether CUB domain containing protein 1 (CDCP1), a single-pass transmembrane protein highly overexpressed in diverse human cancers, might be a target for cancer theranostics.

Experimental Design: The ectodomain of CDCP1 was targeted using radiolabeled forms of 4A06, a potent and specific recombinant human antibody that we developed.

[Candidemia combined with bacterial bloodstream infection: analysis of clinical features and associated risk factors].

Objective: To investigate the clinical characteristics of and risk factors for candidemia combined with bacterial bloodstream infection(BSI) by retrospective analysis of cases.

Method: The clinical data of cases diagnosed as candidemia combined with BSI confirmed by blood culture were compared with those of cases with mono-candidemia in Beiing Tongren Hospital from January 2009 to December 2011. A logistic regression analysis was performed to investigate the independent risk factors.

Imbalance between subpopulations of regulatory T cells in COPD.

Background: Recent evidence indicates that human regulatory T cells (Tregs) are composed of three distinct subpopulations: CD25(++) CD45RA(+) resting Tregs (rTregs), CD25(+++) CD45RA(-) activated Tregs (aTregs), which are suppressive, and CD25(++) CD45RA(-) cytokine-secreting (Fr III) cells with pro-inflammatory capacity.

Objectives: To evaluate the dynamic changes in circulating and pulmonary Treg subpopulations in smokers and patients with chronic obstructive pulmonary disease (COPD), and to explore their potential roles in COPD pathogenesis.

Methods: Blood samples were obtained from 57 never-smokers, 32 smokers with normal lung function and 66 patients with COPD.

Comparing the transmission potential of Methicillin-resistant Staphylococcus aureus and multidrug-resistant Acinetobacter baumannii among inpatients using target environmental monitoring.

Background: With the increasing isolation rate of multidrug-resistant Acinetobacter baumannii (MDR-AB) in China hospitals, more researches focused on its antimicrobial resistance, but few studies reported its nosocomial transmission. In this study, we aim to investigate the transmission features of MDR-AB among inpatients using target environmental monitoring.

Methods: Methicillin-resistant Staphylococcus aureus (MRSA) and MDR-AB active screening and target environmental screening were performed from March 2010 to October 2011 in respiratory intensive care unit (RICU).

[A comparative clinical analysis of thoracic sarcoidosis and multi-organ sarcoidosis].

Objective: To investigate the clinical characteristics of thoracic sarcoidosis compared with multi-organ sarcoidosis.

Methods: The clinical data of 24 patients with thoracic sarcoidosis and 29 patients with multi-organ sarcoidosis histologically diagnosed at Beijing Tongren Hospital from 1995 to 2010 were retrospectively analyzed. The demographic data, clinical manifestations, diagnostic procedures, involved organs, serum angiotensin converting enzyme (ACE) levels, lung functions, and cellular characteristics of bronchoalveolar lavage fluid (BALF) were compared.

Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial.

Objective: Noninvasive positive pressure ventilation is beneficial for patients with acute respiratory failure. However, its possible benefit for patients with acute lung injury (200 mm Hg < PaO(2)/FIO(2) ≤300 mm Hg) remains unclear. Our aim was to assess the safety and efficacy of noninvasive positive pressure ventilation for patients with acute lung injury and compare this with high-concentration oxygen therapy.

Colonization pressure adjusted by degree of environmental contamination: a better indicator for predicting methicillin-resistant Staphylococcus aureus acquisition.

Background: Colonization pressure has been confirmed as an important risk factor for methicillin-resistant Staphylococcus aureus (MRSA) acquisition among inpatients, but their precise relationship has not been well investigated. Because MRSA carriers can disperse MRSA into their immediate environment with different abilities, the relationship among colonization pressure, the degree of MRSA contamination in environment surrounding MRSA carriers, and MRSA transmission should be explored to facilitate efficient implementation of infection control measures.

Methods: Active MRSA screening and environmental sampling were performed in a 23-bed emergency ward (EW) and a 7-bed respiratory intensive care unit (RICU) between March 2009 and February 2010.