Analysis of risk factors for poor healing and long-duration pain in conservative treatment of rib fractures.

Rib fractures are a common injury following blunt chest trauma, accounting for approximately 10% of all traumatic injuries and up to 50% of blunt chest trauma cases. These fractures are associated with a high risk of complications, such as pneumothorax, hemothorax, and pulmonary infections, and can significantly impact respiratory function. This study analyzes the risk factors for poor healing and long-duration pain in the conservative treatment of rib fractures, providing a reference for clinicians in choosing conservative treatment and formulating treatment plans.

Irisin reprograms microglia through activation of STAT6 and prevents cognitive dysfunction after surgery in mice.

Postoperative cognitive dysfunction (POCD) is common in the aged population and associated with poor clinical outcomes. Irisin, an endogenous molecule that mediates the beneficial effects of exercise, has shown neuroprotective potential in several models of neurological diseases. Here we show that preoperative serum level of irisin is reduced in dementia patients over the age of 70.

Relationship between burnout and turnover intention among nurses: a network analysis.

Background: Nurse burnout and turnover intention significantly impact global healthcare systems, especially intensified by the COVID-19 pandemic. This study employs network analysis to explore these phenomena, providing insights into the interdependencies and potential intervention points within the constructs of burnout and turnover intention among nurses.

Methods: A cross-sectional study was conducted with 560 nurses from three tertiary hospitals in Hangzhou, China.

["Shugan Tiaoshen" needling improves depression after ischemic stroke by regulating AMPK-dependent autophagy].

Objectives: To observe the effect of "Shugan Tiaoshen"(soothing the liver and regulating the mental activities) needling on the expressions of AMP-activated protein kinase (AMPK) and autophagy-related proteins in the prefrontal cortex of rats with depression after ischemic stroke (post-stroke depression), in order to explore its mechanisms underlying improvement of post-stroke depression behaviors.

Methods: A total of 60 male SD rats were randomly divided into sham operation (control), stroke, post-stroke depression, inhibitor, acupuncture, and acupuncture + inhibitor groups. The post-stroke depression model was established by occlusion of the middle cerebral artery and reperfusion (MCAO/R), combined with chronic unpredictable mild stimulation (CUMS).

Simultaneous elimination mechanism of formaldehyde and acrolein by resveratrol in food and the cytotoxicity of the products.

Polyphenols have been intensively investigated for scavenging single harmful aldehydes, such as formaldehyde (FA) and acrolein (ACR). However, there is a lack of studies on the effect and mechanism of eliminating co-existing harmful aldehydes by polyphenols. In this study, resveratrol (RV) was found to simultaneously scavenge FA and ACR by forming various adducts, with the RV-ACR adduct (RA, molecular formula: CHO) and RV-ACR-FA adduct (RAF, molecular formula: CHO) being the dominant ones.

One-pot synthesis of supported sub-micron LaNi for hydrogen storage in a carbazole-type liquid organic hydrogen carrier.

Metal hydrides are promising catalysts in hydrogen-involving reactions. However, downsizing and loading metal hydrides is difficult due to their sensitivity towards oxygen and water. Here, a simple one-pot molten salt synthetical method is proposed to synthesize porous La(OH)-supported LaNi.

Machine learning-based dynamic predictive models for prognosis and treatment decisions in patients with liver metastases from gastric cancer.

Gastric cancer with liver metastasis (GCLM) often has a poor prognosis. Therefore, it is crucial to identify risk factors affecting their overall survival (OS) and cancer-specific survival (CSS). This study aimed to construct practical machine learning models to predict survival time and help clinicians choose appropriate treatments.

VaxLLM: Leveraging Fine-tuned Large Language Model for automated annotation of Vaccines.

Background: Vaccines play a vital role in enhancing immune defense and preventing the hosts against a wide range of diseases. However, research relating to vaccine annotation remains a labor-intensive task due to the ever-increasing volume of scientific literature. This study explores the application of Large Language Models (LLMs) to automate the classification and annotation of scientific literature on vaccines as exemplified on vaccines.

Engineered β1-3--Acetylglucosaminyltransferase Facilitating the One-Pot Multienzyme Synthesis of Human Milk Oligosaccharides.

β1-3-linked -acetylglucosaminide is a prevalent carbohydrate motif found in oligosaccharides, polysaccharides, glycoproteins, and glycolipids. It is a crucial component of human milk oligosaccharides (HMOs). β1-3--acetylglucosaminyltransferase (NmLgtA) catalyzes the formation of a glycosidic bond and has the potential for use in synthesizing HMOs.

A Comprehensive Analysis of the Epidemiological and Genomic Characteristics of Global Serratia marcescens.

Background: Serratia marcescens outbreaks present significant challenges in clinical treatment, necessitating a deeper understanding of its epidemiological and genomic traits.

Objective: To analyze the epidemiological and genomic characteristics of S. marcescens at a global scale.

Telehealth and Telemedicine in the Management of Adult Patients after Liver Transplantation: A Scoping Review.

Telemedicine can support home-based self-care for liver transplant recipients after discharge from the hospital. This study aimed to (1) provide an overview of the forms of home care for liver transplant patients; (2) identify the content elements of telemedicine in the home care of liver transplant patients; and (3) summarize the effect and outcome indexes of using telemedicine in liver transplantation patients. A search was performed in the electronic databases of PubMed, CINAHL, Web of Science, Cochrane Library, Embase, Google Scholar, CNKI, Wan Fang data and Wei Pu database through March 1, 2024.

ILDIM-MFAM: interstitial lung disease identification model with multi-modal fusion attention mechanism.

This study aims to address the potential and challenges of multimodal medical information in the diagnosis of interstitial lung disease (ILD) by developing an ILD identification model (ILDIM) based on the multimodal fusion attention mechanism (MFAM) to improve the accuracy and reliability of ILD. Large-scale multimodal medical information data, including chest CT image slices, physiological indicator time series data, and patient history text information were collected. These data are professionally cleaned and normalized to ensure data quality and consistency.

Sex Difference and Socioeconomic Inequity in Chinese People With Hypertension: National Cross-Sectional Survey Study.

Background: Sex differences in blood pressure (BP) levels and hypertension are important and the role of socioeconomic status (SES) in sex differences in hypertension remains unclear.

Objective: This study aimed to evaluate the impact of SES on sex differences of hypertension in a nationally representative survey study.

Methods: A total of 98,658 participants aged ≥18 years who have lived in their current residence for ≥6 months were recruited from 162 study sites across mainland China.

Development and Field Deployment of a ppb-Level SO/NO Dual-Gas Sensor System for Agricultural Early Fire Identification.

Sulfur dioxide (SO) and nitrogen dioxide (NO) are chemical indicators of crop straw combustion as well as significant atmospheric pollutants. It is challenging to promptly detect natural "wildfires" during agricultural production, which often lead to uncontrollable and substantial economic losses. Moreover, both "wildfires" and artificial "straw burning" practices pose severe threats to the ecological environment and human health.

One-step gas-phase syntheses of few-layered single-phase TiNCl and TiCCl MXenes with high stabilities.

With the iteration of etching techniques, MXenes have exhibited astounding accomplishments. Nevertheless, intricate procedures, expensive precursors, and degradation present obstacles for practical application. Although chemical vapor deposition has been developed as a solution, direct syntheses of few-layered single-phase MXenes remain an open challenge, especially for TiNCl.

Kaempferol modulates ɑ2M secretion in bone marrow-derived macrophages by downregulating GR/PER1-mediated lipid metabolism to attenuate the emotional stress-aggravated metastasis of prostate cancer.

Ethnopharmacological Relevance: Prostate cancer patients often suffer from depression during androgen deprivation therapy. Chaihu-Shugan-San (CSS) can prevent prostate cancer metastasis caused by chronic unpredictable mild stress (CUMS), but its active ingredients and molecular mechanism remain unelucidated.

Aim Of Study: This study aims to explore the potential targets and molecular mechanisms of CSS in the treatment of emotional stress-aggravated metastasis of prostate cancer.

Bidirectional Two-Sample, Two-Step Mendelian Randomisation Study Reveals Mediating Role of Gut Microbiota Between Vitamin B Supplementation and Alzheimer's Disease.

Objectives: Alzheimer's disease (AD) is a devastating neurodegenerative disorder with a complex aetiology. The aims of this study were to investigate the relationship between vitamin B supplementation and AD risk and to explore the potential mediating effect of the gut microbiota in this relationship.

Methods: We employed a Mendelian randomisation analysis to examine the association between different vitamin B supplementation modalities (vitamin B, folic acid, B, and vitamin B complex tablets) and AD risk.

Orf116b Induces Pollen Abortion in a Novel Cotton ( L.) Cytoplasmic Male Sterile Line J4A.

Cytoplasmic male sterile (CMS) systems have great potential in hybrid seed production in many plants. However, the incompatibility between the cytoplasmic and nuclear genes and the availability of fewer CMS lines limit the system's application in cotton heterosis. Therefore, the present study sequenced the mitochondrial (mt) genomes of a novel cotton ( L.

Unlocking the Potentials of Large Language Models in Orthodontics: A Scoping Review.

(1) Background: In recent years, large language models (LLMs) such as ChatGPT have gained significant attention in various fields, including dentistry. This scoping review aims to examine the current applications and explore potential uses of LLMs in the orthodontic domain, shedding light on how they might improve dental healthcare. (2) Methods: We carried out a comprehensive search in five electronic databases, namely PubMed, Scopus, Embase, ProQuest and Web of Science.

Brain multi-omic Mendelian randomisation to identify novel drug targets for gliomagenesis.

Background: Genetic variants associated with molecular traits that are also associated with liability to glioma can provide causal evidence for the identification and prioritisation of drug targets.

Methods: We performed comprehensive two-sample Mendelian randomisation (Wald ratio and/or IVW) and colocalisation analyses of molecular traits on glioma. Instrumentable traits (QTLs P < 5 × 10-8) were identified amongst 11 985 gene expression measures, 13 285 splicing isoforms and 10 198 protein abundance measures, derived from 15 brain regions.

Preparation of a chitosan/polyvinyl alcohol-based dual-network hydrogel for use as a potential wound-healing material for the sustainable release of drugs.

Treating chronic wounds poses significant challenges in clinical medicine due to bacterial infection, reactive oxygen species (ROS) accumulation, and excessive inflammation. This study aimed to address these issues by developing a wound dressing with antibacterial, antioxidant, and anti-inflammatory properties. Chitosan was functionally modified with acrolein to covalently bind to epigallocatechin gallate (EGCG), enabling a high EGCG load.