Objective: To analyze the effect of interventional surgery on treatment efficacy and inflammatory cytokine (ICK) levels in diabetic patients with peripheral vascular disease (PVD).
Methods: A total of 116 diabetic patients with PVD admitted to the Second Affiliated Hospital of Guangzhou Medical University from August 2020 to March 2022 were selected for this retrospective analysis. Patients were divided into two groups: 58 patients receiving conventional medication were assigned to the control group, while 58 patients receiving interventional surgery in addition to conventional medication were assigned to the research group.
Primary intracranial malignant melanoma(PIMM) is often difficult to treat in patients without a history of skin melanoma or extensive melanin deposition. Due to the rarity of the disease, the current accepted treatment is surgical resection, but the prognosis is still poor. We report a case of PIMM in an adolescent girl with epilepsy as the only symptom and atypical imaging findings.
View Article and Find Full Text PDFThis study employed first-principles calculations to comprehensively explore the structural, electronic, and magnetic properties of transition metal-doped biphenylene networks (BPNs). Initially, we optimized the most stable structures of biphenylene doped with various transition metals (Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, and Zn) and analysed their doping energies and electronic structures in detail. The results indicate that the introduction of transition metals induces varying degrees of spin polarization.
View Article and Find Full Text PDFAims: For displaced femoral neck fractures (FNFs) in geriatric patients, there remains uncertainty regarding the effect of total hip arthroplasty (THA) compared with hemiarthroplasty (HA) in the guidelines. We aimed to compare 90-day surgical readmission, in-hospital complications, and charges between THA and HA in these patients.
Methods: The Hospital Quality Monitoring System was queried from 1 January 2013 to 31 December 2019 for displaced FNFs in geriatric patients treated with THA or HA.
Importance: Clinicians often approach urate-lowering therapy (ULT) cautiously in patients with gout and impaired kidney function because they are concerned about the risk of progression to severe or end-stage kidney disease. However, evidence from randomized clinical trials of this association remains inconclusive.
Objective: To evaluate the association between achieving target serum urate level with ULT and progression of chronic kidney disease (CKD) to severe or end-stage in patients with gout and impaired kidney function.
Background: This study utilizes a Knowledge, Attitude, and Practice (KAP) questionnaire to investigate the awareness of medical professionals in the Ningxia region regarding research integrity and their attitudes towards academic misconduct. A comprehensive analysis of the factors contributing to academic misconduct is performed, with the aim of providing insights for the formulation of policies to enhance research integrity.
Methods: This study is a cross-sectional study.
This work proposes an innovative method for monitoring the freshness of aquatic products using a nanosized colorimetric sensor (NCS). Six porous organic frameworks (POFs) were utilised to modify and sensitize four food-friendly natural pigments. Four optimal nano-pigments were selected based on their RGB-responsive interaction with NH.
View Article and Find Full Text PDFObjective: To evaluate the effectiveness and safety of concurrent chemoradiotherapy using Endostar continuous infusion for treating oesophageal squamous cell carcinoma (OSCC).
Method: A total of 62 patients with oesophageal carcinoma were divided into three groups: the Endostar continuous infusion group ( = 27), the Endostar intravenous drip group ( = 21) and the concurrent chemoradiotherapy group ( = 14). All patients underwent oesophageal radiotherapy (56-60 Gy) alongside concurrent chemotherapy (4 mg of raltitrexed +100 mg of oxaliplatin, two cycles).
Background: The presence of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies in dermatomyositis (DM) is associated with an increased risk of developing rapidly progressive interstitial lung disease (RP-ILD) and a poor prognosis.
Objectives: We aimed to explore whether tofacitinib could improve the prognosis of Anti-MDA5 antibody positive DM-interstitial lung disease (ILD).
Design: Systematic review and meta-analysis.
Nano zerovalent iron (nZVI) has been broadly used in the treatment of chromium (Cr) pollution. However, conventional nZVI particles are prone to surface oxidation and particle agglomeration, limiting their effectiveness in contaminant removal. To address these issues, sulfidated nZVI (S-nZVI) was synthesized on the corn stover biochar (BC) surface for rapid removal of Cr(VI) from water.
View Article and Find Full Text PDFSurface modification of metallic nanocatalysts with organic ligands has emerged as an effective strategy to enhance catalytic selectivity, although often at the expense of catalytic activity. In this study, we demonstrate a compelling approach by surface modifying PdS nanocrystals with PPh ligands, resulting in a catalyst with excellent catalytic activity and durable selectivity for the semi-hydrogenation of terminal alkynes. Experimental and theoretical investigations reveal that the presence of S sites on the Pd surface directs PPh ligands to preferentially form covalent bonds with S, creating distinctive surface S=PPh motifs.
View Article and Find Full Text PDFBackground: To date, no randomized controlled trials have specifically addressed behavior changes after HIV self-testing (HIVST) among transgender women.
Objective: This study aims to evaluate the effects of HIVST on changes in HIV testing behavior, frequency of condomless sex, and partner numbers among transgender women in China.
Methods: Participants were recruited from 2 Chinese cities using both online and offline methods.
Invasive fungal infections (IFIs) pose a significant threat to immunocompromised individuals, leading to considerable morbidity and mortality. Prompt and accurate diagnosis is essential for effective treatment. Here we develop a rapid molecular diagnostic method that involves three steps: fungal enrichment using affinity-magnetic separation (AMS), genomic DNA extraction with silicon hydroxyl magnetic beads, and detection through a one-pot system.
View Article and Find Full Text PDFEmerged evidence indicated that stimulating hippocampal neurogenesis is a potential strategy for restoring cognition in AD. Mitogen-activated protein kinases (MAPKs) play an essential role in neurogenesis. Meanwhile, the enzymatic power of the phosphatases is much greater than that of kinases.
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