Association between oral dryness and dysphagia in community-dwelling older population.

Objective: There remains inconsistent recognition of the relationship between oral dryness and dysphagia. This study aimed to investigate whether the degree of oral dryness was related to the prevalence of dysphagia in community-dwelling older adults.

Design: A cross-sectional study.

A dynamic transcriptional cell atlas of testes development after birth in Hu sheep.

Background: Testes development is a fundamental process in sexual development and reproduction. The testes undergo dramatic structural changes during development, including the proliferation and differentiation of somatic cells such as Sertoli cells, Leydig cells, and myoid cells, as well as the maturation of spermatogonia. However, little is known about the onset of spermatogenesis and cell proliferation and maturation in the spermatogonial niche in large animals.

Deformation Control of Adjustable-Ring-Mode (ARM) Laser Welding for Aluminum Alloys.

In the domain of new energy vehicles, the control of welding deformation in aluminum alloy battery systems poses substantial challenges. The existing methodologies for diminishing welding deformation, such as laser segmented skip welding, alteration of welding path sequences, numerical simulation prediction, and post-weld heat treatment, still possess room for further optimization when applied to intricate welding structures. In this research, a novel adjustable-ring-mode laser in conjunction with the oscillation welding technique was employed to explore the impacts of fiber core diameter, laser light field brightness distribution, and process parameters on weld formation.

Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations.

Lugdunin was the first reported new class of thiazolidine cyclopeptide antibiotic from human microbiomes. However, its structure could not accommodate polar amino acids or modules, limiting its potential for chemical modification and clinical application. Herein, we developed a combinatorial modification strategy based on in situ modification of tryptophan through a radical reaction and amino acid site-specific mutation, transforming lugdunin into a cationic cyclic peptide antibiotic.

A framework for the construction of effective landscape ecological network with integrating hydrological connectivity: A case study in Dongjiang River Basin, China.

The rise in frequency of extreme climate events has led to notable variation in water storage capacity within many basins around the world, resulting in the simultaneous occurrence of seasonal water shortages and flooding issues. The development of a basin landscape ecological network that is grounded in hydrological connectivity has the potential to markedly improve ecosystem resilience in the basin as well as to facilitate the integrated advancement of ecological conservation and water resource management. This study assessed the hydrological connectivity of the Dongjiang River Basin, China, in terms of Euclidean distance, over the period from 2000 to 2023.

Activating Halogen Circulation Enables Efficient and Stable Wide-Bandgap Mixed-Halide Perovskite Solar Cells.

Developing strategies to manage ion-migration-induced phase segregation in wide-bandgap (WBG) perovskites is crucial for achieving high-performance perovskite-silicon tandem solar cells (TSCs). However, maintaining continuous suppression of phase segregation from the film crystallization process to device operation remains a significant challenge. The present study demonstrates an efficient strategy of activating halogen circulation in WBG perovskite by using halogen circulation agents (HCA) of N-halosuccinimide molecules as the sustainable stabilizers, in order to achieve dynamic halogen equilibrium within the precursor solution and perovskite film, which blocks the migration path of Br/I ions both in crystallization and aging of WBG perovskites.

A mechanism study of tripartite motif 10 modulating septic cardiomyopathy.

Objective: Septic cardiomyopathy (SCM), as a complication of the septic process, severely affects the myocardial function of patients, but its pathogenesis remains unclear. The article aims to explore the mechanism of tripartite motif 10 (TRIM10) in rats with SCM and provide animal experimental basis for the treatment and prevention of SCM.

Material And Methods: An SCM rat model was constructed by intraperitoneal injection of lipopolysaccharide (LPS).

Knocking-down annexin A3 suppresses inflammation, oxidative stress, apoptosis, and endoplasmic reticulum stress to attenuate sepsis-induced acute kidney injury in HK2 cells.

Objective: Sepsis-induced acute kidney injury (AKI) is considered as a life-threatening complication of sepsis. The purpose of this study is to clarify the involvement of annexin A3 (ANXA3) in sepsis-related AKI.

Material And Methods: Lipopolysaccharide (LPS) was used to establish a cell model based on HK2 cells.

Exploring Oxonitridosilicate Synthesis: From Oxide Zeolites to Nitride Frameworks.

In this study, we synthesized the first CAN (crinite)-typed zeolite-like oxonitridosilicates, CaO(SiNO)[SiN] ( = La and Ce). The crystal structure of LaCaO(SiNO)[SiN] was determined through single-crystal X-ray diffraction (SCXRD) data and neutron powder diffraction (NPD) data refinement. The compound crystallizes in hexagonal space group 6 (No.

Color fundus photograph-based diabetic retinopathy grading via label relaxed collaborative learning on deep features and radiomics features.

Introduction: Diabetic retinopathy (DR) has long been recognized as a common complication of diabetes, making accurate automated grading of its severity essential. Color fundus photographs play a crucial role in the grading of DR. With the advancement of artificial intelligence technologies, numerous researchers have conducted studies on DR grading based on deep features and radiomic features extracted from color fundus photographs.

NHC-Based Deep-Red Phosphorescent Iridium Complexes Featuring Three-Charge (0, -1, -2) Ligands.

N-heterocyclic carbene (NHC)-based phosphorescent iridium complexes have attracted extensive attention due to their good optical properties and high stability in recent years. However, currently reported NHC-based iridium complexes can easily achieve emission of blue, green, or even ultraviolet light, while emission of red or deep-red light is relatively rare. Here, we report a new family of NHC-based deep-red iridium complexes (Ir1, Ir2, Ir3, and Ir4) featuring three-charge (0, -1, -2) ligands.

External Validation of a 5-Factor Risk Model for Breast Cancer-Related Lymphedema.

Importance: Secondary lymphedema is a common, harmful side effect of breast cancer treatment. Robust risk models that are externally validated are needed to facilitate clinical translation. A published risk model used 5 accessible clinical factors to predict the development of breast cancer-related lymphedema; this model included a patient's mammographic breast density as a novel predictive factor.

Risk prediction models for falls in hospitalized older patients: a systematic review and meta-analysis.

Background: Existing fall risk assessment tools in clinical settings often lack accuracy. Although an increasing number of fall risk prediction models have been developed for hospitalized older patients in recent years, it remains unclear how useful these models are for clinical practice and future research.

Objectives: To systematically review published studies of fall risk prediction models for hospitalized older adults.

Wafer-scale monolayer MoS film integration for stable, efficient perovskite solar cells.

One of the primary challenges in commercializing perovskite solar cells (PSCs) is achieving both high power conversion efficiency (PCE) and sufficient stability. We integrate wafer-scale continuous monolayer MoS buffers at the top and bottom of a perovskite layer through a transfer process. These films physically block ion migration of perovskite into carrier transport layers and chemically stabilize the formamidinium lead iodide phase through strong coordination interaction.

Identifying priority conservation areas for threatened amphibian habitats in the Yangtze river Delta region to maintain regional biodiversity.

The complex life cycle traits of amphibians make them especially sensitive to environmental change, and their ongoing conservation requires the maintenance of suitable habitat that accounts for such life cycle characteristics which may impacted by local environmental dynamics arising from climate change and human disturbance. Many existing studies on amphibian habitats disregard this important issue, leading to uncertainty in managing critical habitats. The application of appropriate conservation practices is therefore constrained by the fact that the major factors influencing amphibian habitats, and their spatio-temporal dynamics at different life stages, are poorly understood.

Evolutionary dynamics and regulatory site analysis of AMP family genes in cattle and sheep.

Background: Ruminants possess a rich repository of natural antimicrobial peptides(AMPs) within their bodies, surpassing those found in humans and mice. These peptides, including Defensin, Cathelicidin, and Lysozyme, are integral to the body's innate and adaptive immune responses and represent promising alternatives to antibiotics with significant application potential.

Results: In the present study, we conducted a systematic analysis of 40 Defensins, 38 Cathelicidins, and 61 Lysozymes in cattle and sheep.

[Effect of Dendrobii Officinalis Caulis water extract on hyperviscosity rats based on TLR4/NF-κB/ICAM-1 signaling pathway].

This study aims to reveal the effect and mechanism of Dendrobii Officinalis Caulis water extract on the rat model of hyperviscosity induced by a high-sugar, high-salt, and high-fat diet. Thirty-six male SD rats were randomized into normal, model, Compound Danshen Tablets(0.5 g·kg~(-1)), and low-, medium-, and high-dose(0.

[Effects of different fractions of Polygonati Rhizoma on reproductive dysfunction in male mice with kidney essence deficiency].

This study aims to reveal the effects and mechanisms of different fractions of Polygonati Rhizoma on the reproductive dysfunction in male mice with kidney essence deficiency due to excess of sexual intercourse. Fifty male ICR mice with good sexual function were selected and randomized into normal(NC), model(MC), n-butanol fraction of Polygonati Rhizoma(0.4 g·kg~(-1), HJCT), remaining fraction of Polygonati Rhizoma(0.

[Protective effect of Polygonati Rhizoma aqueous extract on gastric mucosal injury in mice induced by overtaking pungent substances and alcohol via TRAF1/ASK1/JNK pathway].

This study aims to investigate the effect and potential mechanism of Polygonati Rhizoma aqueous extract in protecting mice from gastric mucosal injury(stomach Yin deficiency). ICR mice were administrated with the mixture of pungent substance extract and alcohol by gavage once a day for 6 weeks to establish the mouse model of gastric mucosal injury with gastric Yin deficiency. The modeled mice were randomized into three groups of model and Polygonati Rhizoma aqueous extract administrated at 0.

Information Source Characteristics of Personal Data Leakage During the COVID-19 Pandemic in China: Observational Study.

Background: During the COVID-19 pandemic, in the period of preventing and controlling the spread of the virus, a large amount of personal data was collected in China, and privacy leakage incidents occurred.

Objective: We aimed to examine the information source characteristics of personal data leakage during the COVID-19 pandemic in China.

Methods: We extracted information source characteristics of 40 personal data leakage cases using open coding and analyzed the data with 1D and 2D matrices.

Unraveling the cGAS/STING signaling mechanism: impact on glycerolipid metabolism and diseases.

The cyclic GMP-AMP synthase (cGAS) and its downstream effector, the stimulator of interferon genes (STING), are crucial components of the innate immune response, traditionally recognized for their role in detecting cytosolic DNA from pathogens and damaged host cells. However, recent research indicates that the cGAS-STING pathway also significantly impacts metabolic processes, particularly glycerolipid metabolism. Glycerolipids are essential for energy storage and cellular membrane integrity, and their dysregulation is linked to metabolic disorders such as obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD).

Myeloid-Derived Suppressor Cells Induce Exhaustion-Like CD8 T Cells during JEV Infection.

Japanese encephalitis (JE), caused by Japanese encephalitis virus (JEV), is a mosquito-borne zoonotic disease and a leading cause of viral encephalitis worldwide. While JEV has the ability to traverse the blood-brain barrier (BBB), the precise mechanisms by which it inhibits the immune response prior to penetrating the BBB remain unclear, presenting obstacles in the development of efficacious therapeutic interventions. This study investigated the impact of JEV on CD8 T cell responses, with a particular focus on the dysfunction of CD8 T cells during JEV infection.

1D Flat Bands in Phosphorene Nanoribbons with Pentagonal Nature.

Materials with flat bands can serve as a promising platform to investigate strongly interacting phenomena. However, experimental realization of ideal flat bands is mostly limited to artificial lattices or moiré systems. Here, a general way is reported to construct 1D flat bands in phosphorene nanoribbons (PNRs) with a pentagonal nature: penta-hexa-PNRs and penta-dodeca-PNRs, wherein the corresponding 1D flat bands are directly verified by using angle-resolved photoemission spectroscopy.

, and serve as potential molecular biomarkers for sepsis based on bioinformatics analysis.

Purpose: Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. However, the relationship between biomarkers and sepsis remains unclear. This study aimed to find potential molecular biomarkers, which could do some help to patients with sepsis.