miR-495-3p depresses cell proliferation and migration by downregulating HMGB1 in colorectal cancer.

Background: MicroRNAs play an important role in the genesis and progression of tumours, including colorectal cancer (CRC), which has a high morbidity and mortality rate. In this research, the role of miR-495-3p and HMGB1 in CRC was investigated.

Methods: We performed qRT-PCR to detect the expression of miR-495-3p in colorectal cancer tissues and cell lines.

Research progress review on long non-coding RNA in colorectal cancer.

Colorectal cancer (CRC) is one of the most common malignancies globally, and the morbidity and mortality rates associated with it are among the highest around the world. Not even great advances in colorectal cancer diagnosis and treatment technologies have been able to increase the 5-year survival rate in this disease. Recidivation and metastasis are the main causes of death in CRC, although the underlying mechanism remains unknown.

Nano-oleanolic acid alleviates metabolic dysfunctions in rats with high fat and fructose diet.

Obesity, diabetes and related metabolic disorders are among the top prevalent metabolism-related diseases with increasing threat to human health throughout the world. Oleanolic acid (OA) is a natural triterpenoid and an aglycone of many saponins possessing anti-diabetic, antioxidant, hypolipidemic and anti-inflammatory activities. A nano-formulation of OA was recently developed to evaluate the efficiency of nano-OA in the treatment of insulin-resistance and metabolic disorders in high fat and fructose (HFF) diet-fed rats.

[Effects of different phosphorus sources on the growth and toxin production of Prorocentrum lima].

To explore the nutrient properties of Prorocentrum lima and biosynthesis mechanism of diarrhetic shellfish poison (DSP), the growth and activities of alkaline phosphatase of Prorocentrum lima were observed under different phosphorus sources. DSP productions were also analyzed. The maximum growth rate (micro(max)) was slightly lower under beta-sodium glycerophosphate than those under NaH2PO4 and ATP as phosphorus sources, respectively.