Gut microbiota alterations in golden snub-nosed monkeys during food shortage and parturition-nursing periods.

Adopting unique survival strategies during spring food shortages and simultaneous parturition and nursing is crucial for golden snub-nosed monkeys. Social behaviors, such as altruism within one-male units (OMUs), are decisive for family health, but the role of microbiota in regulating these behaviors remains unknown. We conducted the gut microbiota from members of 10 OMUs using 16S RNA sequencing technology.

Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma: The DIPPER Randomized Clinical Trial.

Importance: Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role in locoregionally advanced NPC is unclear.

Objective: To evaluate the efficacy and safety of adjuvant camrelizumab for patients with locoregionally advanced NPC.

March2 Alleviates Aortic Aneurysm/Dissection by Regulating PKM2 Polymerization.

Background: Aortic aneurysm/dissection (AAD) is a life-threatening disease lacking effective pharmacological treatment. Protein ubiquitination plays a pivotal role in cardiovascular diseases. However, the possible contribution of the E3 ubiquitin ligase March2 (membrane-associated RING finger protein 2) to the cause of AAD remains elusive.

Unraveling the Causal Relationship Between 731 Immunocyte Phenotypes and Asthma Risk: A Bidirectional Mendelian Randomization Analysis.

Growing evidence suggests an association between various immune cell phenotypes and the development of asthma. However, it is still not entirely clear whether specific immune cell phenotypes might causally contribute to the risk of asthma. Despite further studies required to validate this claim, our study delves deeper into explaining this relationship and paving the way toward new therapeutic approaches.

The impacts of technological overlap on international collaboration in China's green innovation endeavors.

North-South cooperation in green innovation activities is an essential avenue for promoting global climate governance. This study examines the impact of technological overlap on the scale of international cooperation in environmental technologies (ETs) between Chinese and foreign geographical units. The results show that technological overlap significantly increases the scale of international cooperation in ETs.

ChREBP Mediates Metabolic Remodeling in FBP1-deficient Liver.

The deficiency of fructose-1,6-bisphosphatase 1 (FBP1), a key enzyme of gluconeogenesis, causes fatty liver. However, its underlying mechanism and physiological significance are not fully understood. Here we demonstrate that carbohydrate response element-binding protein (ChREBP) mediates lipid metabolic remodeling and promotes progressive triglycerides accumulation against metabolic injury in adult FBP1-deficient liver.

Global landscape of hepatic organoid research: A bibliometric and visual study.

Background: Hepatic organoid-based modelling, through the elucidation of a range of biological processes and the recreation of the intricate liver microenvironment, is yielding groundbreaking insights into the pathophysiology and personalized medicine approaches for liver diseases.

Aim: This study was designed to analyse the global scientific output of hepatic organoid research and assess current achievements and future trends through bibliometric analysis.

Methods: Articles were retrieved from the Web of Science Core Collection, and CiteSpace 6.

SERS/Fluorescence Dual-Modal Imaging Bioprobe for Accurate Diagnosis of Breast Cancer.

Early diagnosis and precise identification of breast cancer subtypes are vital. However, current detection methods are often hindered by high costs and complexity. This study aims to develop an efficient and noninvasive method to realize efficient breast cancer detection.

Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial.

HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively targets vascular endothelial growth factor receptor-2, endothelial growth factor receptor, and fibroblast growth factor receptor 1-3. The safety, pharmacokinetics, and efficacy of HA121-28 were assessed in advanced solid tumors (phase 1, ClinicalTrials.gov NCT03994484) and advanced RET fusion-positive non-small-cell lung cancer (RET-TKI naive NSCLC, phase 2, ClinicalTrials.

Efficacy and safety of ongericimab in Chinese patients with heterozygous familial hypercholesterolemia: A randomized, double-blind, placebo-controlled phase 3 trial.

Background And Aims: Heterozygous familial hypercholesterolemia (HeFH) is a prevalent autosomal dominant disorder of lipid metabolism but severely underdiagnosed and undertreated in China. This phase 3 trial aims to evaluate the efficacy and safety of ongericimab, a novel monoclonal antibody that targets proprotein convertase subtilisin/kexin type 9 (PCSK9), in Chinese patients with HeFH.

Methods: Patients who have been diagnosed with definite HeFH according to Dutch Lipid Clinical Network criteria and receiving stable and optimized lipid-lowering therapy were enrolled.

Dupilumab Efficacy and Safety in Patients With Persistent Asthma: Asia-Pacific Region.

Background: Asthma prevalence is increasing in the Asia-Pacific region. China and India account for > 35% of the world's population and are often underrepresented in clinical studies. This phase 3 study (NCT03782532) evaluated efficacy and safety of dupilumab, a monoclonal antibody blocking interleukin-4/13 signalling, in patients with persistent asthma from China and India.

A Multicenter Study of Hereditary Transthyretin Amyloidosis in China.

Objective: Hereditary transthyretin amyloidosis (ATTRv) is an autosomal dominant genetic disease characterized by the misfolding and deposition of the transthyretin (TTR) protein. This study aimed to describe the clinical and genetic characteristics of ATTRv in a large multicenter Chinese cohort.

Methods: Patients from 14 centers were included in the study.

Analysis of Ultrasound Features for Breast Cancers With Different Risk Categories and Evaluation of a New Predicting Method.

Objectives: To explore pathology and ultrasound features of breast cancers with different risk categories. To establish and validate a nomogram primarily based on grayscale ultrasound features for non-invasive preoperative prediction of high-risk breast cancers and for rapid individual risk assessment and clinical decision making.

Methods: A total of 685 breast malignant lesions were enrolled in this study.

Review of the application of dual-energy CT combined with radiomics in the diagnosis and analysis of lung cancer.

Lung cancer is one of the most common malignant tumors in the world. Early detection and precise treatment are of great significance to clinical decision-making and patient prognosis. As an emerging imaging technology, dual-energy computed tomography (DECT) has increasingly prominent advantages in multi-parameter and quantitative analysis in assessing the benign and malignant, classification, and prognosis of lung cancer.

Apolipoprotein D is crucial for promoting perineural invasion in salivary adenoid cystic carcinoma.

Background: Perineural invasion (PNI) is a prevalent phenomenon in salivary adenoid cystic carcinoma (SACC). Nevertheless, the regulatory mechanism of PNI is largely elusive.

Methods: We detected Apolipoprotein D (ApoD) expression and further determined its role in SACC progression.

A real-world study on the characteristics of autoimmune gastritis: A single-center retrospective cohort in China.

Background And Aim: Autoimmune gastritis (AIG) was previously considered a rare disease in China, and its clinical characteristics were not fully understood. This study aimed to demonstrate the characteristics of AIG in China and evaluate gastric oxyntic mucosal atrophy using a modified AIG-atrophic staging.

Methods: This was a single-center retrospective observational real-world study.

A nomogram for predicting prognosis for young cervical neuroendocrine carcinoma: A SEER-based study and external validation.

Background: Neuroendocrine carcinoma of the cervix (NECC) is a rare and highly aggressive subtype of cervical carcinomas with poor prognosis. NECC tends to occur in young age which could severely impair mental and physical health of young patients. Therefore, this study aims to develop an individualized prognostic nomogram for young NECC patients.

Acetate prevents pistil dysfunction in rice under heat stress by inducing methyl jasmonate and quercetin synthesis.

Introduction: Acetic acid (HAC) is a crucial signal molecule in plant stress responses; however, its role in conferring heat tolerance to rice remains unclear.

Objectives: This study aims to investigate the effect of HAC in protecting pistil function under heat stress and its potential role in facilitating pollen germination and tube growth via HAC-induced synthesis of methyl jasmonate (MeJA) and quercetin (QR).

Methods: Physiological analysis, including pollen germination, pollen tube growth into the ovule, reactive oxygen species (ROS), as well as the levels of HAC, acetyl coenzyme A (acetyl-CoA), MeJA, and QR in the pistils of heat stress-treated early indica rice cultivars Zhongzao39 (ZZ39) and Zhongjiazao17 (ZJZ17), were conducted.

Criticality in the Luria-Delbrück Model with an Arbitrary Mutation Rate.

The Luria-Delbrück model is a classic model of population dynamics with random mutations, that has been used historically to prove that random mutations drive evolution. In typical scenarios, the relevant mutation rate is exceedingly small, and mutants are counted only at the final time point. Here, inspired by recent experiments on DNA repair, we study a mathematical model that is formally equivalent to the Luria-Delbrück setup, with the repair rate p playing the role of mutation rate, albeit taking on large values, of order unity per cell division.

Identification of increased dedifferentiation along the Prom1+ cancer cells in Müllerian adenosarcoma with sarcomatous overgrowth.

Background: Müllerian adenosarcoma (MA) is a rare tumour accounts for 5-7% of uterine sarcomas. Tumours with sarcomatous overgrowth (MASO) or high-grade tend to be aggressive. However, the tumour aetiology is elusive.

Survival analysis between different treatment strategies of mixed adenoneuroendocrine carcinoma (MANEC): a population-based study.

Background: Mixed adenoneuroendocrine carcinoma (MANEC) is rare and heterogeneous. Currently, there is no concise treatment standard for MANEC. This study aimed to explore the prognostic impact of different treatment methods in MANEC.

Association between weight-adjusted waist index and cognitive impairment in Chinese older men: a 7-year longitudinal study.

Background: Obesity, through mechanisms such as insulin resistance and systemic low-grade inflammation, can damage the central nervous system and impair cognitive function. Weight-adjusted waist index (WWI) is a novel measure of obesity that may offer more precise assessments of muscle and fat mass. This study aims to investigate the association between WWI and cognitive function in older Chinese men.

A Novel Platinum-Resistance-related Gene Signature in Ovarian Cancer: Identification and Patient-derived Organoids Verification.

Background: Platinum-based chemotherapy resistance is one of the main contributors to the mortality of Ovarian Cancer (OC). It is believed that sensitive biomarkers for identifying the population that is platinum-resistant are urgently needed. This study aims to develop a platinum-resistance gene-based signature to predict OC patients' responses to platinum drugs as well as survival outcomes.