Publications by authors named "Jie Hye Kim"
The aim of this study is to evaluate whether the blood perfusion to tissues for detecting ischemic necrosis can be quantitatively monitored by spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) in a skin flap mouse model. Skin flaps were made on Institute of Cancer Research (ICR) mice. Using SFDI and LSI, the following parameters were estimated: oxyhemoglobin (HbO), deoxyhemoglobin (Hb), total hemoglobin (THb), tissue oxygen saturation (StO), and speckle flow index (SFI).
View Article and Find Full Text PDFBackground And Objectives: To evaluate the antiallergic effect of low-level laser irradiation (LLLI) at 650 nm in a mouse model of allergic rhinitis (AR), and to examine the underlying mechanisms.
Study Design/materials And Methods: BALB/c mice were sensitized with ovalbumin (OVA) and alum and challenged intranasally with OVA. Straight- and diffusion-type LLLI were applied directly into the intranasal cavity of the mice once daily for 10 days (650 nm, 5 mW, 15 min/day) and multiple allergic parameters were evaluated.
Article Synopsis
- Cigarette smoke exposure significantly worsens symptoms and pathology in a murine model of eosinophilic rhinosinusitis with nasal polyps (ERSwNPs), leading to increased polyp-like lesions and eosinophil infiltration.
- Mice exposed to cigarette smoke showed elevated levels of inflammatory cytokines (such as IL-4 and IL-17A) and structural changes in the nasal tissues, indicating more severe airway inflammation and remodeling.
- The study suggests that the aggravation of eosinophilic inflammation and nasal polyp formation due to cigarette smoke is linked to increased expressions of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF) 1-alpha